2020
DOI: 10.1186/s13008-020-00062-5
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Toll signaling promotes JNK-dependent apoptosis in Drosophila

Abstract: Background: Apoptosis plays pivotal roles in organ development and tissue homeostasis, with its major function to remove unhealthy cells that may compromise the fitness of the organism. Toll signaling, with the ancient evolutionary origin, regulates embryonic dorsal-ventral patterning, axon targeting and degeneration, and innate immunity. Using Drosophila as a genetic model, we characterized the role of Toll signaling in apoptotic cell death. Results: We found that gain of Toll signaling is able to trigger cas… Show more

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Cited by 21 publications
(25 citation statements)
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“…We have also reported earlier that Dx interacts with the JNK pathway ligand Eiger and regulates Eiger mediated signaling activity (Dutta, Singh, et al, 2018). JNK activity is needed for Toll-induced cell death in Drosophila (Li et al 2020). Gain of JNK signaling not only inflicts cell death but also activates Toll pathway marked by an increased nuclear localization of Dorsal (Wu et al 2015).…”
Section: Co-localizes With Dorsal In the Cell Nucleus And The Nusupporting
confidence: 70%
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“…We have also reported earlier that Dx interacts with the JNK pathway ligand Eiger and regulates Eiger mediated signaling activity (Dutta, Singh, et al, 2018). JNK activity is needed for Toll-induced cell death in Drosophila (Li et al 2020). Gain of JNK signaling not only inflicts cell death but also activates Toll pathway marked by an increased nuclear localization of Dorsal (Wu et al 2015).…”
Section: Co-localizes With Dorsal In the Cell Nucleus And The Nusupporting
confidence: 70%
“…JNK activity is needed for Toll‐induced cell death in Drosophila (Li et al. 2020). Gain of JNK signaling not only inflicts cell death but also activates Toll pathway marked by an increased nuclear localization of Dorsal (Wu et al.…”
Section: Resultsmentioning
confidence: 99%
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“…Mechanically, emodin could protect against intestinal and lung injury induced by acute intestinal injury in rats via SP-A and TLR4/NF-κB pathway. TLRs play an important role in the regulation of phagocytosis of acute inflammatory response cells [21], cell signaling [22] and apoptosis [23]. Among all TLRs, the ligand of TLR4 is lipopolysaccharide, a cell wall component of Gram-negative bacteria.…”
Section: Discussionmentioning
confidence: 99%