Toluene‐exposed workers and chromosome aberrations

Abstract

Peripheral blood lymphocytes from 32 male rotogravure workers with daily exposure to toluene were studied for chromosome aberrations and sister chromatid exchange. Neither of these two cytogenetic parameters differed significantly from the correspondong frequencies in 15 unexposed control subjects. However, a significant increase in sister chromatid exchange was observed among smokers, both exposed and occupationally unexposed, compared to nonsmoking referents.

Chromosome aberrations in peripheral lymphocytes of workers employed in the plywood industry.

“…The whole-bl ood lymphocyte cultures, two from each sample, were set up as previously described (8) and were cultivated for 48 h. The cells were harvested, fixed, put on slides , and stained as reporte d earlier (9,10). The dupl icate cultures were united at harvest.…”

Chromosome changes in workers (smokers and nonsmokers) exposed to automobile fuels and exhaust gases.

“…Data on both chromosome aberrations and SCEs were collected from 32 rotogravure workers exposed to toluene and 15 referents (19), but the results were not analyzed with respect to the correlation between aberrations and SCEs. However, smokers had a significantly higher SCE frequency than nonsmokers, whereas the rate of chromosome aberrations did not seem to be significantly increased among smokers.…”

Chromosome aberrations and sister chromatid exchanges in styrene‐exposed workers with reference to their smoking habits

“…However, the results are controversial because some studies demonstrate positive correlations, whereas others result in negative ones. Information on the combined effects of exposure to organic solvents and cigarette smoking also have been presented [Lambert et al, 1978;Lambert and Lindblad, 1980;Anderson et al, 1980;Husgafvel-Pursiainen et al, 1980;Maki-Paakkanen et al, 1980;Bauchinger et al, 1982al.…”