Tomato saponin supplementation ameliorates the development of experimental arthritis by regulating inflammatory responses

Yoshikawa, Yuko; Katayanagi, Yuki; Kamiya, Manatsu; Yamamoto, Yuri; Fukutomi, Ryuta; Imai, Shoichi; Miyoshi, Noriyuki; Ohashi, Norio

doi:10.1016/j.jff.2018.09.009

Cited by 6 publications

(7 citation statements)

References 42 publications

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“…57 Okamoto et al 72 of the included studies. 47,48,53,64,68,69,70,75,77,78,80 However, Khayyal et al 63 did not detect a significant decrease in serum levels of TNFα, IL-6 and CRP with 5 mg/kg curcumin. Likewise, Fan et al 56 detected no significant decrease in the serum levels of TNFα, IL-1 and IL-6.…”

Section: Curcumin Effect On Inflammatory Markers and Matrix Metalloproteinasesmentioning

confidence: 95%

“…47,79,83 Curcumin effect on histological and arthritis score Twenty-eight studies assessed the effect of curcumin on histological and arthritis scores in animal models of RA. Yoshikawa et al 78 showed that curcumin significantly decreased the arthritis score. Silva et al 52 showed that curcumin at the dose of 25 mg/ kg, significantly reduced the edema formation, thermal hyperalgesia and arthritis score.…”

Section: Curcumin Effect On Radiographic Scorementioning

confidence: 99%

“…(n = 6) 57,68,69,72,75,78 ; and Balb/c (n = 1) 58 ) or rats (Wistar (n = 1 9) 47,49,51,52,53,54,55,56,60,62,63,64,65,66,67,70,71,82,83 ; Sprague-Dawley (n = 9) 48,50,61,74,76,77,79,80,81 ; Charles Foster (n = 1) 73 and in one study there was no information about the kind of rats 59 ). The induction of RA was performed by injection of complete Freund's adjuvant (CFA) (n = 19), 47,48,49,50,51,52,54,55,63,64,65,66,67,70,73,…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Moon et al 68 found that intraperitoneally injection with 50 μg curcumin significantly reduced the levels of IgG2a Ab production, but anti-CII IgG1 Ab levels were slightly reduced. Yoshikawa et al 78 showed that curcumin reduced the INFγ, TGFβ and receptor activator of nuclear factor-kappa-Β ligand (RANKL) mRNA expression in the knee joints. In another study, 50 mg/kg curcumin significantly decreased the mRNA expression of BAFF in splenocytes.…”

Section: Other Effects and Mechanismsmentioning

confidence: 99%

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Curcumin and rheumatoid arthritis: A systematic review of literature

2021

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Background: Curcumin is a natural polyphenol and the main compound from the rhizome of Turmeric (Curcuma longa) and other Curcuma species. It has been widely used for different medical purposes, such as improvement of pain and inflammatory conditions in various diseases.Purpose: This systematic review was aimed to assess all studies regarding the efficacy of the pure form of curcumin (unformulated curcumin) on rheumatoid arthritis (RA). Methods: The comprehensive search of the literature was done until September 2020 on the MEDLINE, Embase, Scopus and Web of Knowledge databases. Out of 2079 initial records, 51 articles (13 in vitro and 37 animal and one human) were met our inclusion criteria. Results: Most studies have shown the curative effects of curcumin on clinical and inflammatory parameters of RA and reported different mechanisms; inhibition of mitogen-activated protein kinase family, extracellular signal-regulated protein kinase, activator protein-1 and nuclear factor kappa B are the main mechanisms associated with the anti-inflammatory function of curcumin in RA. The results of the only human study showed that curcumin significantly improved morning stiffness, walking time and joint swelling. Conclusion:In conclusion, curcumin seems to be useful, and it is recommended that more human studies be performed to approve the cellular and animal results and determine the effective and optimal doses of curcumin on RA patients. Review criteria• The MEDLINE database (PubMed), Embase, Scopus, and Thomson Reuters Web of Knowledge were systematically and comprehensively searched until September 2020, using related keywords.• All English written original in vitro, animal, and human studies on the effects of curcumin on RA were included.

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Section: Curcumin Effect On Inflammatory Markers and Matrix Metalloproteinasesmentioning

confidence: 95%

Section: Curcumin Effect On Radiographic Scorementioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Other Effects and Mechanismsmentioning

confidence: 99%

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Curcumin and rheumatoid arthritis: A systematic review of literature

2021

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“…Regarding the anti‐allergic and anti‐inflammatory effects of saponins, timosaponin, a steroidal saponin, has been shown to ameliorate UV‐induced inflammation in human keratinocytes (Kim et al., 2019). Esculeoside A, a steroidal saponin that is structurally similar to LH, was isolated from Japanese tomato and found to suppress type II collagen‐induced arthritis in mice and induce Th2 cytokine responses (Yoshikawa et al., 2018). This effect of esculeoside A markedly differs from that of LH, which reduced Th2 cytokine concentrations in IL‐33Tg mice.…”

Section: Discussionmentioning

confidence: 99%

Lycoperoside H, a steroidal alkaloid saponin in tomato seeds, ameliorates atopic dermatitis‐like symptoms in IL‐33 transgenic mice

2021

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Tomato seeds contain steroidal saponins called lycoperosides. However, it currently remains unclear whether lycoperosides exert anti‐inflammatory or anti‐allergic effects. Therefore, we herein investigated the effects of tomato seed extract (TSE) and lycoperoside H (LH) in Interleukin (IL)‐33 transgenic mice. TSE (500 mg/kg) or LH (10 mg/kg) was orally administered once a day for 101 days and then evaluated mouse behavior, skin symptoms, and blood and skin inflammatory cytokines. TSE slightly suppressed scratching behavior, while TSE and LH both increased locomotive activity. LH also significantly suppressed inflammation scores in the limbs, and TSE and LH reduced transepidermal water loss. Epidermal hyperplasia and the accumulation of eosinophils and mast cells were decreased by TSE and LH. Skin Th2/Th1 cytokine ratio and serum IgE concentrations were significantly reduced by TSE and LH. The present results suggest that the oral administration of LH derived from tomato seeds effectively ameliorates the symptoms of atopic dermatitis. Practical applications It has been reported that tomato seeds contain steroidal saponins, lycoperosides, though the effects of lycoperosides on anti‐inflammatory or anti‐allergic have not yet been revealed. In this study, we demonstrated that the oral administration of lycoperoside H derived from tomato seeds suppressed atopic dermatitis symptoms in IL‐33 transgenic mice.

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