“…7 The etiology of the IOP rise has been hypothesized to result from increased episcleral venous pressure, orbital pressure on the globe, choroidal expansion, or a combination of the three. [6][7][8] Although long-duration studies of IOP in microgravity have not been performed, short duration space shuttle and head-down studies suggest that the eye may rapidly undergo adaptive changes to blunt the initial spike in IOP. 6,8 During descent, the Soyuz module falls toward Earth, reaching a deceleration of C4.0 to 4.5 Gx (eyeballs in).…”