Tomographic Task-Related Functional Near-Infrared Spectroscopy in Acute Sport-Related Concussion: An Observational Case Study

Forcione, Mario; Chiarelli, Antonio Maria; Perpetuini, David; Davies, David; O’Halloran, Patrick; Hacker, David; Belli, Antonio

doi:10.3390/ijms21176273

Cited by 3 publications

(1 citation statement)

References 89 publications

(109 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Functional near-infrared spectroscopy (fNIRS) is a technology that is increasingly being applied to monitor brain function in healthy, diseased, or injured brains 1 – 6 As it is portable and relatively accessible in terms of data collection and processing, and it may rival MRI for assessing brain function in a wide range of neurological conditions including concussion. Concussion is a mild traumatic brain injury (mTBI) that results in altered neurological states leading to symptoms of memory and perception deficits, headaches, and other behavioral changes 7 …”

Section: Introductionmentioning

confidence: 99%

Impact of averaging fNIRS regional coherence data when monitoring people with long term post-concussion symptoms

et al. 2023

View full text Add to dashboard Cite

Functional near-infrared spectroscopy (fNIRS), with its measure of delta hemoglobin concentration, has shown promise as a monitoring tool for the functional assessment of neurological disorders and brain injury. Analysis of fNIRS data often involves averaging data from several channel pairs in a region. Although this greatly reduces the processing time, it is uncertain how it affects the ability to detect changes post injury.Aim: We aimed to determine how averaging data within regions impacts the ability to differentiate between post-concussion and healthy controls.Approach: We compared interhemispheric coherence data from 16 channel pairs across the left and right dorsolateral prefrontal cortex during a task and a rest period. We compared the statistical power for differentiating groups that was obtained when undertaking no averaging, vs. averaging data from 2, 4, or 8 source detector pairs. Results: Coherence was significantly reduced in the concussion group compared with controls when no averaging was undertaken. Averaging all 8 channel pairs before undertaking the coherence analysis resulted in no group differences.Conclusions: Averaging between fiber pairs may eliminate the ability to detect group differences. It is proposed that even adjacent fiber pairs may have unique information, so averaging must be done with caution when monitoring brain disorders or injury.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of averaging fNIRS regional coherence data when monitoring people with long term post-concussion symptoms

et al. 2023

View full text Add to dashboard Cite

show abstract

Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers

Forcione,

Chiarelli,

Perpetuini

et al. 2024

Preprint

View full text Add to dashboard Cite

Significance: Current systems for diffuse optical tomography (DOT) are unsuitable for clinical applications on acute traumatic brain injury (TBI) patients while in the intensive care unit (ICU). Aim: To develop and test a method for DOT recordings suitable for TBI patients in the ICU. This method is based on measurements and co-registration using 3-D optical scans, and the acquisition of optical data using a custom-made helmet which would enable a multimodal (invasive and non-invasive) neuromonitoring. Approach: Probe displacements compared to electromagnetic digitization co-registrations were assessed. The capacity to isolate and monitor, using functional near-infrared spectroscopy (fNIRS), the optical signal in the intracranial (ICT) and extracranial tissues (ECT) was tested on 23 healthy volunteers. Participants were scanned with a frequency-domain NIRS device (690 and 830 nm) during 5 Valsalva maneuvers (VM) in a simulated ICU environment. Results: The results showed an average error in probe displacement of 5.5 mm, a sufficient capacity to isolate oxyhemoglobin O2Hb (p=6.4E10-6) and total hemoglobin HbT (p=2.8E10-5 27 ) in the ICT from the ECT, and to follow the changes of hemoglobin in the ICT during the VM (O2Hb, p=9.2E10-4; HbT, p=1.0E10-3). Conclusions: The developed approach appears to be suitable for use on TBI patients in the ICU.

show abstract

Sensor-Assisted Analysis of Autonomic and Cerebrovascular Dysregulation following Concussion in an Individual with a History of Ten Concussions: A Case Study

Kennedy,

Burma,

Smirl

2024

Sensors

View full text Add to dashboard Cite

Introduction: Concussion is known to cause transient autonomic and cerebrovascular dysregulation that generally recovers; however, few studies have focused on individuals with an extensive concussion history. Method: The case was a 26-year-old male with a history of 10 concussions, diagnosed for bipolar type II disorder, mild attention-deficit hyperactivity disorder, and a history of migraines/headaches. The case was medicated with Valproic Acid and Escitalopram. Sensor-based baseline data were collected within six months of his injury and on days 1–5, 10, and 14 post-injury. Symptom reporting, heart rate variability (HRV), neurovascular coupling (NVC), and dynamic cerebral autoregulation (dCA) assessments were completed using numerous biomedical devices (i.e., transcranial Doppler ultrasound, 3-lead electrocardiography, finger photoplethysmography). Results: Total symptom and symptom severity scores were higher for the first-week post-injury, with physical and emotional symptoms being the most impacted. The NVC response showed lowered activation in the first three days post-injury, while autonomic (HRV) and autoregulation (dCA) were impaired across all testing visits occurring in the first 14 days following his concussion. Conclusions: Despite symptom resolution, the case demonstrated ongoing autonomic and autoregulatory dysfunction. Larger samples examining individuals with an extensive history of concussion are warranted to understand the chronic physiological changes that occur following cumulative concussions through biosensing devices.

show abstract

Tomographic Task-Related Functional Near-Infrared Spectroscopy in Acute Sport-Related Concussion: An Observational Case Study

Cited by 3 publications

References 89 publications

Impact of averaging fNIRS regional coherence data when monitoring people with long term post-concussion symptoms

Impact of averaging fNIRS regional coherence data when monitoring people with long term post-concussion symptoms

Diffuse optical tomography system for acute traumatic brain injury in the intensive care unit: a prospective study on healthy volunteers

Sensor-Assisted Analysis of Autonomic and Cerebrovascular Dysregulation following Concussion in an Individual with a History of Ten Concussions: A Case Study

Contact Info

Product

Resources

About