Tone-dependent responses of histamine in feline pulmonary vascular bed

Neely, C. F.; Matot, Idit; Haile, D.; Nguyen, J.; Batra, Vandana

doi:10.1152/ajpheart.1995.268.2.h653

Cited by 3 publications

(2 citation statements)

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“…Evidence exists that each of these mediators may modulate pulmonary vascular tone both in vitro and in vivo (10,41,48). The pulmonary vascular responses to histamine and serotonin are receptor-and tone-dependent with developmental changes (9,21,34). In mature animals, histamine and serotonin typically cause an H 1 and 4-HT 2a receptor-mediated increase in PVR (9,21).…”

Section: Discussionmentioning

confidence: 99%

Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus

Houfflin‐Debarge¹,

Delelis²,

Jaillard³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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The fetus is able to exhibit a stress response to painful events, and stress hormones have been shown to modulate pulmonary vascular tone. At birth, the increased level of stress hormones plays a significant role in the adaptation to postnatal life. We therefore hypothesized that pain may alter pulmonary circulation in the perinatal period. The hemodynamic response to subcutaneous injection of formalin, which is used in experimental studies as nociceptive stimulus, was evaluated in chronically prepared, fetal lambs. Fetal lambs were operated on at 128 days gestation. Catheters were placed into the ascending aorta, superior vena cava, and main pulmonary artery. An ultrasonic flow transducer was placed around the left pulmonary artery. Three subcutaneous catheters were placed in the lambs' limb. The hemodynamic responses to subcutaneous injection of formalin, to formalin after fetal analgesia by sufentanil, and to sufentanil alone were recorded. Cortisol and catecholamine concentrations were also measured. Pulmonary vascular resistances (PVR) increased by 42% (P Ͻ 0.0001) after formalin injection. Cortisol increased by 54% (P ϭ 0.05). During sufentanil infusion, PVR did not change significantly after formalin. Cortisol increased by 56% (P Ͻ 0.05). PVR did not change during sufentanil infusion. Norepinephrine levels did not change during any of the protocols. Our results indicate that nociceptive stimuli may increase the pulmonary vascular tone. This response is not mediated by an increase in circulating catecholamine levels. Analgesia prevents this effect. We speculate that this pulmonary vascular response to nociceptive stimulation may explain some hypoxemic events observed in newborn infants during painful intensive care procedures. experimental pain animal model; fetal pain; fetal analgesia; pulmonary vascular reactivity; stress hormones THE DEVELOPMENT OF FETAL INVASIVE procedures and a better knowledge about pain in preterm and full-term newborn infants have led to increased interest in the subject of fetal pain. Nociception during early development is poorly understood. However, numerous indirect evidence such as behavioral or neurohormonal responses to invasive procedures suggests that the fetus can feel pain very early in gestation (17,18,20). Fetal brain-sparing response has been observed after procedures involving transgression of fetal trunk from as early as 16 wk (54). Furthermore, transfusion through the intrahepatic veins is associated with substantial rises in stress hormones (norepinephrine, cortisol, ␤-endorphin) from as early as 18 wk of gestation (17,18).At birth, the increase in stress hormones plays a significant role in the adaptation to postnatal life, including increased left ventricular contractility, lung fluid reabsorption, and surfactant release (11,25,35,47,49,60). Stress hormones have also been shown to modulate the pulmonary vascular tone and reactivity during the perinatal life (12,26,29). These data suggest that perinatal stress may alter the pulmonary circulation. Furthermore, hyp...

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Section: Discussionmentioning

confidence: 99%

Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus

Houfflin‐Debarge¹,

Delelis²,

Jaillard³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

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“…The range of species and vascular beds studied may well explain the diversity of results reported, but another factor may be the physiological conditions in each case. Vascular tone, for example, has been shown to influence vasoactive responses of the feline pulmonary vasculature (17). The issue oftone dependency of vascular responses is of significance in vascular diseases such as systemic hypertension or diabetes.…”

Section: Introductionmentioning

confidence: 99%

Acetylcholine-Induced Relaxation in Rat Ocular Vasculature

Yu¹,

Yu²,

Cringle³

et al. 2000

Journal of Ocular Pharmacology and Therapeutics

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Endothelial cell function is often evaluated by the assessment ofendothelium-dependent relaxation to acetylcholine. The purpose of this study was to characterize the acetylcholine-induced vasodilator responses in the intact ocular vasculature tree in isolated perfused rat eyes. At a fixed perfusion flow rate (5 microl/min), the resultant perfusion pressure reflected the total vascular resistance of the perfused vasculature. The baseline vascular resistance, and hence perfusion pressure, was manipulated by perfusion with high concentrations of potassium Krebs (60, 90, or 124 mM). The response to bolus administration of acetylcholine (10(-8) to 10(-4) M) was then assessed over a range of perfusion pressures. Acetylcholine induced a dose-dependent relaxation response which was larger in magnitude with increased levels of induced vascular tone. The relationship between the size of the acetylcholine-induced response and the baseline perfusion pressure was essentially linear with a correlation coefficient of 0.86 at 10(-5) M and of 0.88 at 10(-4) M acetylcholine. Our results suggest that, in the isolated perfused rat eye, the initial vascular tone has to be considered when evaluating endothelial cell function by acetylcholine-induced relaxation.

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R-(−)-α-methyl-histamine has nitric oxide-mediated vasodilator activity in the mesenteric vascular bed of the cat

Champion

Kadowitz

1998

European Journal of Pharmacology

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Tone-dependent responses of histamine in feline pulmonary vascular bed

Cited by 3 publications

References 0 publications

Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus

Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus

Acetylcholine-Induced Relaxation in Rat Ocular Vasculature

R-(−)-α-methyl-histamine has nitric oxide-mediated vasodilator activity in the mesenteric vascular bed of the cat

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