Tongue cancer in younger patients

Abstract

Tongue cancer involving the anterior tongue often presents at an early stage. The aetiology is strongly associated with smoking and alcohol abuse similar to other squamous cell carcinomas (SCC) of the head and neck (HN). Surgery and radiotherapy, either alone or together, offer the prospect of cure in the majority of patients. However, there remains a group of younger patients less than 40 years old for whom outcome is often poor. Presented here is the case of a 24-year-old woman who developed SCC of the anterior tongue. Despite treatment, loco-regional relapse occurred resulting in death. The literature identifies a distinct subgroup of younger patients who develop HN SCC, particularly of the oral cavity. The aetiology remains unclear. Recent studies have looked at the prognostic significance of various new non-clinico-pathological markers in HN SCC (including p53 tumour suppressor gene, cyclin D1 protein, Ki 67 antigen and tumour angiogenesis). The majority of these studies, as expected, have involved the typical HN patient (male, aged > 60 years old). However, the relevance of these studies is of likely importance to all patients diagnosed with HN SCC. The recent use of these non-clinical-pathological markers in HN SCC, including reference to such studies in younger patients, is discussed. The English literature during the past 30 years is reviewed with reference to the diagnosis of tongue SCC in younger patients.

Anterior Tongue Cancer: Age Is Not a Predictor of Outcome and Should Not Alter Treatment

“…The age definition of a young head and neck patient is arbitrary and has been variously defined as less than 30, 40 or 50 years of age 2−8 . Most recent studies have defined ≤40 years of age as a young patient.…”

Tongue cancer: Do patients younger than 40 do worse?

“…8 Yet, despite these findings the incidence of oral cancer in young patients is increasing 9 and there have been multiple studies documenting a poor outcome for young patients diagnosed with SCCOT. 2,[10][11][12] The aim of this single institution retrospective study was to identify prognostic variables following diagnosis and treatment for SCCOT. In particular, age at diagnosis was investigated as a potential predictor for survival.…”

Oral cavity squamous cell carcinomas in young patients in a selected Malaysian centre

“…Young patients are defined as those between the age of 35–40 years or below 14–16 . Previously, it was thought that OSCC had a very poor prognosis, particularly if it involved young patients 16–18 .…”