From the beginning of the XXI century between the processes of regional systems globalization and location development resources bigger contradictions can be seen. Balanced spatial development of territories is in ideal concepts and models for economics and society formation. But their implementation is under the influence of risks and threads. The uncial properties of regional systems are underestimated and their resource potential is used not reasonably. Thereby the strategic drift of globalization itself becomes not the fillip, but thread of perspective regional systems development. This investigation is dedicated to grounding ways to overcome its negative influence. Within this investigation we formulate a problem of global order tendencies analyses; development of new management tasks, including the formats of institutional norms, transforming the process of reproduction; forming of adaptive space reorganization procedure considering the lack of localized resources factor. Scientific novelty of the investigation is on optimization of the actual methods and tools for strategic management the territories and grounding the perspectives regional systems polistructural modelling. This allows to reduce strategic drift of globalization risks, modify regional economics evolution driving force and decrease human resources investigation process turbulence, assets, plots of land, preserve the integrality of the formed space and minimize its disbalance.