Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research

Aviello, Gabriella; D’Agostino, Giuseppe

doi:10.3389/fphar.2016.00043

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…For example, when using designer receptors exclusively activated by designer drugs (DREADDs), spatial specificity is only possible with high-resolution delivery of the modulatory drug, which can be an obstacle in the GI tract. 150 The implementation of opto-genetic techniques at mucosal sites may also be hampered by the further need to develop a portable and stable micro device that allow normal behaviour in mice. 150 Nevertheless, the more recent development of a transparent graphene sensor with a customized abdominal window may allow, in the future, to harness opto-genetics to study neuro-immune interactions at mucosal sites.…”

Section: Discussionmentioning

confidence: 99%

“…150 The implementation of opto-genetic techniques at mucosal sites may also be hampered by the further need to develop a portable and stable micro device that allow normal behaviour in mice. 150 Nevertheless, the more recent development of a transparent graphene sensor with a customized abdominal window may allow, in the future, to harness opto-genetics to study neuro-immune interactions at mucosal sites. 151 A deeper understanding of how neuro-immune interactions regulate tissue and organ physiology is a major challenge in the future.…”

Section: Discussionmentioning

confidence: 99%

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Neuro-immune regulation of mucosal physiology

2019

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Mucosal barriers constitute major body surfaces that are in constant contact with the external environment. Mucosal sites are densely populated by a myriad of distinct neurons and immune cell types that sense, integrate and respond to multiple environmental cues. In the recent past, neuro-immune interactions have been reported to play central roles in mucosal health and disease, including chronic inflammatory conditions, allergy and infectious diseases. Discrete neuro-immune cell units act as building blocks of this bidirectional multi-tissue cross-talk, ensuring mucosal tissue health and integrity. Herein, we will focus on reciprocal neuro-immune interactions in the airways and intestine. Such neuro-immune cross-talk maximizes sensing and integration of environmental aggressions, which can be considered an important paradigm shift in our current views of mucosal physiology and immune regulation.

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Section: Discussionmentioning

confidence: 99%