Tooth agenesis patterns in unilateral cleft lip and palate in humans

Bartzela, Theodosia; Carels, Carine; Bronkhorst, Ewald M.; Kuijpers-Jagtman, Anne Marie

doi:10.1016/j.archoralbio.2012.12.007

Cited by 46 publications

(70 citation statements)

References 35 publications

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“…These results are in concordance with other research reports [14]. Still, the majority of the patients belonged to the CL + P L group (38.3%) in agreement with relative research investigations [9, 15, 20]. …”

Section: Discussionsupporting

confidence: 93%

“…Additionally, dental anomalies appear more commonly in the cleft rather than the non-cleft area [4, 10, 12–14]. It is reported that the prevalence of left-sided clefts is higher than right-sided clefts; the cause still remaining unknown [9, 15]. Data from the literature indicate that isolated cleft lip patients (CL) seem to be less affected by dental anomalies outside the cleft area compared to CP or CL + P patients [7].…”

Section: Introductionmentioning

confidence: 99%

“…Still, the lateral incisor is reported as the most frequently missing tooth in cleft patients [3, 6, 13, 15, 16]. Also, according to a recent study, the prevalence of lateral incisor agenesis increases in respect to the severity of the cleft [16].…”

Section: Introductionmentioning

confidence: 99%

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A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

et al. 2017

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BackgroundThe aim of this study was to investigate the prevalence of tooth agenesis, microdontia, and tooth malformation among non-syndromic oral cleft patients and their potential association with cleft type and gender.MethodsIntraoral records and radiographs of 154 patients (97 males and 57 females) were examined. The variables assessed were tooth agenesis, microdontia, dental malformations, and cleft types. The statistics included chi-square and Fisher’s exact tests as well as logistic regression to assess any mutual effects of gender and cleft type on the dental variables.ResultsTooth agenesis occurred in 50% of the sample and microdontia in 18%. Non-statistically significant odds ratios for the association of gender and cleft type with tooth agenesis were obtained. Tooth agenesis was substantially higher at the unilateral right CL + P and the bilateral CL + P in quadrant 1 and at the unilateral left CL + P and bilateral CL + P in quadrant 2. It was also higher, at the isolated cleft palate (CP) in quadrants 3 and 4. These results were attributed to teeth 22 (31.8%) and 12 (21.6%) in the maxilla and to teeth 35 (6.1%) and 45 (5.4%) in the mandible. In unilateral CL + P patients, the cleft quadrant that presented tooth agenesis was associated with the side of the cleft.ConclusionsInterdisciplinary treatment of the oral cleft patients should take into consideration the high prevalence of tooth agenesis and their association with the different cleft types. The most frequently affected teeth by cleft are by far the upper lateral incisors. Results indicate that tooth agenesis appears to be a genetically controlled anomaly related to the orofacial cleft development through various genetic links and not caused by the cleft disruptive process.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

et al. 2017

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“…The congenital absence of teeth was determined by clinical and radiographic examination using orthopantomogram (OPG). According to the number of missing teeth, subjects were subdivided into three groups: group A -mild (1-2), group Bmoderate (3)(4)(5)(6), and group C -severe (≥7 congenitally missing permanent teeth). The number and average ages of the study groups are presented in Table 1.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of hypodontia in the general population varies from 2.3% to 10.1% (excluding third molars). [2][3][4][5] Hypodontia can be associated with a cleft lip and palate, 6,7 and with more than 50 syndromes, 8,9 or may present as an isolated entity. 10,11 Oligodontia is rarer condition and its prevalence in the permanent dentition is between 0.15% and 0.45%.…”

Section: Introductionmentioning

confidence: 99%

Craniofacial morphology in individuals with increasing severity of hypodontia

Bajraktarova-Miševska¹,

Kanurkova²,

Valjakova³

et al. 2016

SEJODR

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Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

Awadh

Kiukkonen

Nieminen

et al. 2017

American J of Med Genetics Pt A

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Blepharocheilodontic (BCD) syndrome is a rare condition characterized by bilateral cleft lip and palate (BCLP), eyelid abnormalities, and oligodontia. Despite orofacial clefting and oligodontia being central features of the condition, detailed reports of dental and craniofacial characteristics are scarce. The aim of this study was to analyze the dental and craniofacial features in a group of patients with BCD syndrome (three of which were related). Cephalometric radiographic analyses were performed on BCD syndrome patients (all radiographs taken at age 8 years) and compared to 40 randomly selected age-matched controls (20 non-syndromic BCLP, 20 non-cleft). Also, we assessed clinical records, photographs, dental study casts, and dental radiographs to determine the extent and pattern of tooth agenesis, dental morphology and malocclusion. BCD syndrome patients showed a very severe skeletal III malocclusion (maxillary-mandibular sagittal discrepancy) and reduced anterior lower face measurement compared to non-syndromic BCLP and non-cleft controls (P = 0.001, P = 0.027). All patients exhibited oligodontia (mean number of missing permanent teeth 13.7, range 7-17). All patients exhibited missing upper central and lateral incisor, upper canine and premolar teeth. Variations in dental morphology included taurodontism, conical-shaped teeth, and notching of the incisal edges. All patients had a short and narrow maxilla which translated into anterior and posterior cross bites. We conclude that, in our BCD syndrome group, the craniofacial skeletal defects are more severe than patients with BCLP. The pattern of tooth agenesis is unusual as it included teeth that are normally highly resistant to agenesis, namely upper central incisor and canine teeth. © 2017 Wiley Periodicals, Inc.

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Tooth agenesis patterns in unilateral cleft lip and palate in humans

Cited by 46 publications

References 35 publications

A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

A cross-sectional analysis of the prevalence of tooth agenesis and structural dental anomalies in association with cleft type in non-syndromic oral cleft patients

Craniofacial morphology in individuals with increasing severity of hypodontia

Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

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