Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

Baranova, Juliana; Büchner, Dominik; Götz, Werner; Schulze, Margit; Tobiasch, Edda

doi:10.3390/ijms21114031

Cited by 49 publications

(44 citation statements)

References 214 publications

(334 reference statements)

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“…The regeneration of a whole tooth is considered to be the ultimate goal of regenerative dentistry. It could be performed as a hybrid strategy, where biologically created tissue compartments such as the periodontal ligament or a tooth crown would be combined with a metallic or ceramic implant or where a biologically regenerated tooth root ("bio-root") would be combined with a prosthetic crown 11 . Efforts in creating a whole tooth from only cells and 612 tissues ("bio-tooth") will be very likely in the focus in the following years 11 .…”

Section: Applications In Oral and Maxillofacialrehabilitation: Whole mentioning

confidence: 99%

“…For the lost tooth regeneration capacity, revitalizing the odontogenic potency may be an interesting approach to induce tooth formation in vivo in the adult.The existence of a successional dental lamina (SDL) carrying the capacity for inducing odontogenesis is the only prerequisite for tooth replacement 11 .…”

Section: Reactivation Of the Odontogenic Potencymentioning

confidence: 99%

“…In classical tissue recombination experiments embryonic tooth germs can be dissociated from native site and later re-aggregated at an ectopic sites. Tooth-like organs with mineralized tissues (dentin and enamel) could be grown after temporary ectopic grafting of these cell aggregates, e.g., into the anterior eye chamber, subcutaneously, or under the renal capsule.The final goal of these experiments was to implant the constructs into the jaws of postnatal animals to generate a whole "bio-tooth" 11 .…”

Section: Tissue Recombination Approachesmentioning

confidence: 99%

“…When combined with mesenchymal cells, adult stem cells should have an odontogenic competence and should function as a "tooth inducer" 11 . Young et al were the first to successfully regenerate tooth structure containing enamel and dentin using tooth buds from the third molars of pigs.…”

Section: Adult Stem Cell Approachesmentioning

confidence: 99%

“…Tooth formation including root occurred and the teeth erupted. In addition, bone was also induced 13 .Volponi Angelova and associates used human gingival epithelial cells combined with embryonic mouse tooth mesenchyme, which yielded an entire tooth outside of an embryo 14 .Research will presumably focus on using adult stem cells from dental and non-dental sources to test recombination or co-culturing for their effects on tooth development in the future 11 .…”

Section: Adult Stem Cell Approachesmentioning

confidence: 99%

See 4 more Smart Citations

Tissue Engineering in Oral and Maxillofacial Rehabilitation - A New Perspective

Kalyani¹,

Janardanan²,

K³

2020

IJAR

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Objective: To collect and conclude a literature review on the applications of tissue engineering in oral and maxillofacial rehabilitation Materials and Methods: The review was searched and collected from many sources about tissue engineering. The database of Literature was collected through the search of PubMed, Google scholar and Researchgate databases. The keywords used for the search were tissue engineering, dental applications, prosthodontics, implant dentistry and craniofacial rehabilitation. A manual search to many of the reference lists of the identified articles and the authors article files and recent reviews was made to find additional publications. Those studies that showed new features about tissue engineering were included in this review. Results: In total 28 literature sources were searched and reviewed. Studies that described new features about elements and strategies of tissue engineering and its applications were included. Conclusion: We summarized in this study the key elements and strategies of tissue engineering and its applications in oral and maxillofacial rehabilitation.

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Section: Applications In Oral and Maxillofacialrehabilitation: Whole mentioning

confidence: 99%

Section: Reactivation Of the Odontogenic Potencymentioning

confidence: 99%

Section: Tissue Recombination Approachesmentioning

confidence: 99%

Section: Adult Stem Cell Approachesmentioning

confidence: 99%

Section: Adult Stem Cell Approachesmentioning

confidence: 99%

See 3 more Smart Citations

Tissue Engineering in Oral and Maxillofacial Rehabilitation - A New Perspective

Kalyani¹,

Janardanan²,

K³

2020

IJAR

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Revitalizing mouse diphyodontic dentition formation by inhibiting the sonic hedgehog signaling pathway

Mao

Lai

Liao

et al. 2021

Developmental Dynamics

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Background Tooth regeneration depends on the longevity of the dental epithelial lamina. However, the exact mechanism of dental lamina regression has not yet been clarified. To explore the role of the Sonic hedgehog (Shh) signaling pathway in regression process of the rudimentary successional dental lamina (RSDL) in mice, we orally administered a single dose of a Shh signaling pathway inhibitor to pregnant mice between embryonic day 13.0 (E13.0) and E17.0. Results We observed that the Shh signaling pathway inhibitor effectively inhibited the expression of Shh signaling pathway components and revitalized RSDL during E15.0–E17.0 by promoting cell proliferation. In addition, mRNA‐seq, reverse transcription plus polymerase chain reaction (RT‐qPCR), and immunohistochemical analyses indicated that diphyodontic dentition formation might be related to FGF signal up‐regulation and the Sostdc1‐Wnt negative feedback loop. Conclusions Overall, our results indicated that the Shh signaling pathway may play an initial role in preventing further development of mouse RSDL in a time‐dependent manner.

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Different grinding speeds affect induced regeneration capacity of human treated dentin matrix

Yang

Song

et al. 2021

J Biomed Mater Res

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Human-treated dentin matrix (hTDM) is a biomaterial scaffold, which can induce implant cells to differentiate into odontoblasts and then form neo-dentin. However, hTDM with long storage or prepared by high-speed handpiece would not to form neo-dentin. In this research, we developed two fresh hTDM with different grinding speeds, which were low-speed hTDM (LTDM) with maximum speed of 500 rpm and high-speed hTDM (HTDM) with a speed of 3,80,000 rpm. Here, we aim to understand whether there were induced regeneration capacity differences between LTDM and HTDM. Scanning electron microscope showed that DFCs grew well on both materials, but the morphology of DFCs and the extracellular matrix was different.Especially, the secreted extracellular matrixes on the inner surface of LTDM were regular morphology and ordered arrangement around the dentin tubules. The transcription-quantitative polymerase chain reaction (qRT-PCR), western blot and immunofluorescence assay showed that the dentin markers DSPP and DMP-1 were about 2Â greater in DFCs induced by LTDM than by HTDM, and osteogenic marker BSP was about 2Â greater in DFCs induced by HTDM than by LTDM. Histological examinations of the harvested grafts observed the formation of neo-tissue were different, and there were neo-dentin formed on the inner surface of LTDM and neocementum formed on the outer surface of HTDM. In summary, it found that the induction abilities of LTDM and HTDM are different, and the dentin matrix is directional. This study lays a necessary foundation for searching the key factors of dentin regeneration in future.high-speed human-treated dentin matrix, induced regeneration capacity, low-speed humantreated dentin matrix, odontogenic differentiation, osteogenic differentiation | INTRODUCTIONBiological scaffolds are currently the most popular scaffold in tissue engineering. [1][2][3] The specific three-dimensional structure, the distinctive extracellular matrix and the most active proteins retained in the Min Li and Sen Yang have contributed equally to this study.

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Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?

Cited by 49 publications

References 214 publications

Tissue Engineering in Oral and Maxillofacial Rehabilitation - A New Perspective

Tissue Engineering in Oral and Maxillofacial Rehabilitation - A New Perspective

Revitalizing mouse diphyodontic dentition formation by inhibiting the sonic hedgehog signaling pathway

Different grinding speeds affect induced regeneration capacity of human treated dentin matrix

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