Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects

Iwasaki, Laura R.; Crouch, Larry D.; Tutor, Albert; Gibson, Scott L.; Hukmani, Navin; Marx, David B.; Nickel, Jeffrey C.

doi:10.1016/j.ajodo.2004.03.037

Cited by 47 publications

(57 citation statements)

References 46 publications

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“…Light continuous force [30,31,42] tended to maintain longer, relatively high IL-1β levels, allowing a reduced frequency of re-activations [43]. These results reveal important clinical implications for orthodontics and provide evidence for the utilization of light continuous force in orthodontics at the cellular level [44], since light continuous forces induce relatively longer lasting levels of cytokines, which are necessary for continuous periodontal remodeling.…”

Section: Discussionmentioning

confidence: 80%

“…Among these studies, further analysis of the titles, abstracts, and fulltexts revealed that 25 were relevant for the present study. A summary of papers that were excluded is presented in Figure 1 (exhibiting the orthodontic mechanics, GCF sampling methods, and cytokine measurements) [1][2][3][4][5][6][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41].…”

Section: Resultsmentioning

confidence: 99%

“…Among the 25 studies, the most commonly studied cytokines were IL-1β (n=12), PGE 2 (n=5), TNF-α (n=7), and IL-6 (n=5) (Figure 1). Four studies [23,30,32,42] had to be excluded from quantitative data synthesis because of insufficient relevant data or fewer than three observation time-points (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…With regard to the speed of tooth movement, Iwasaki et al [23,30,42] observed positive correlation with the IL-1β: IL-1 receptor antagonist (IL-1) ratio.…”

Section: Discussionmentioning

confidence: 99%

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Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: This paper aimed to analyze studies in the literature addressing the role of cytokines in the gingival crevicular fluid (GCF) in the orthodontic treatment. METHODS: Several databases were surveyed using both MESH terms and free terms. Additional studies were obtained by reference tracking. This review was registered in PROSPERO, and the procedures foreseen by its statement were followed. Data were obtained from the included studies addressing the orthodontic mechanics, GCF sampling/handling methods, and cytokine measurements. Clinical studies written in English were browsed. Papers were selected by one reviewer and checked by a second investigator. RESULTS: A total of 115 articles were identified, among which 25 were selected for detailed analysis. Common drawbacks consisted mainly of inadequacies in the study design (e.g. short duration and small number of study subjects). The most consistent result was a peak of cytokine levels at 1 d. Associations were observed between prostaglandin E2 (PGE2) and interleukin-1β (IL-1β) and pain, velocity of tooth movement, and treatment mechanics. Interleukin-1b and PGE2 showed different patterns of up-regulation, with IL-1β being more responsive to mechanical stress and PGE2 more responsive to synergistic regulation of IL-1β and mechanical force. The results support the use of light continuous forces for orthodontic treatment. CONCLUSION: There was a tendency of maintenance of relatively high IL-1β levels for longer periods with the use of light continuous forces, which might decrease the frequency of activation. These outcomes provide evidence at the cellular level for the utilization of light continuous forces.Key words: Systematic review; Orthodontics, corrective; Gingival Crevicular Fluid (GCF); Interleukin; T Cells.Papel das citocinas presentes no fluido crevicular durante o tratamento ortodôntico: uma revisão sistemática REsUMO OBJETIVO: Este artigo teve como objetivo analisar estudos na literatura abordando o papel das citocinas no Líquido do Sulco Gengival no tratamento ortodôntico. MéTODOS: Várias bases de dados foram pesquisadas usando termos MESH e termos livres. Estudos adicionais foram obtidos por rastreamento de referência. Esta revisão foi registrada no PROSPERO, e os procedimentos previstos por sua declaração foram seguidos. Os dados foram obtidos dos estudos incluídos sobre a mecânica ortodôntica, métodos de amostragem / manuseio de Líquido do Sulco Gengival e medições de citoquinas. Estudos clínicos escritos em inglês foram pesquisados. Os trabalhos foram selecionados por um revisor e verificados por um segundo investigador. RESULTADOS: Foram identificados 115 artigos, dentre os quais 25 foram selecionados para análise detalhada. As desvantagens comuns consistiram principalmente em insuficiências no design do estudo (por exemplo, curta duração e pequeno número de sujeitos do estudo). O resultado mais consistente foi um pico de níveis de citocinas a 1 d. Foram observadas associações entre prostaglandina E2 (PGE2) e interleucina-1β (IL-1β) ...

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Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…With regard to the speed of tooth movement, Iwasaki et al [23,30,42] observed positive correlation with the IL-1β: IL-1 receptor antagonist (IL-1) ratio.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Cytokines in crevicular fluid and orthodontic force: a systematic review

Allgayer

Menezes

Rinaldi

2017

Rev. Odonto Ciênc. (Online)

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“…Ultimately, these cells form functional units that promote remodeling of the paradental tissues and facilitate the tooth movement. 7 The acute inflammatory process that characterizes the initial stage of orthodontic tooth movement is predominantly exudative, in which plasma and leukocytes migrate outside the capillaries in areas of paradental stress. After one or two days, the acute stage of inflammation is decreased and replaced by a chronic process involving fibroblasts, endothelial cells and osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

Alteração no volume do fluido gengival durante a retração de caninos superiores

Capelli

Fidel²,

Figueredo

et al. 2010

Dental Press J. Orthod.

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Introduction: In the analysis of the pressure-tension theory of tooth movement, the application of an orthodontic force causes gradual displacement of fluids of the periodontal ligament, followed by distortion of the cells and extracellular matrix. Objectives: This study evaluated the gingival fluid volume on the mesial and distal aspects of the maxillary canines of 14 patients (3 males and 11 females) submitted to orthodontic movement. Methods: The fluid was collected using standard absorbent paper strips (Periopaper

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Markers of paradental tissue remodeling in the gingival crevicular fluid and saliva of orthodontic patients

Iwasaki¹

2015

Biological Mechanisms of Tooth Movement

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Tooth movement and cytokines in gingival crevicular fluid and whole blood in growing and adult subjects

Cited by 47 publications

References 46 publications

Cytokines in crevicular fluid and orthodontic force: a systematic review

Cytokines in crevicular fluid and orthodontic force: a systematic review

Alteração no volume do fluido gengival durante a retração de caninos superiores

Markers of paradental tissue remodeling in the gingival crevicular fluid and saliva of orthodontic patients

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