operate in a continuous fashion, over long periods of time outside of clinics, hospitals, and laboratories. [1] Examples include microfluidic devices for capture and biomarker analysis of sweat, [2][3][4][5][6] mechanoacoustic sensors for cardiaovascular diagnostics, [7,8] multinode platforms for full-body pressure/temperature monitoring, [9] technologies for characterizing the skin, [10,11] and its hydration state, [12] miniaturized pulse oximeters, [13,14] UV dosimeters, [15][16][17] and others. Related systems also have utility in biological research, from conformal sheets of electro nics for mapping electrophysiological processes of the brain and the heart [11,18] to thin filamentary probes for optogenetic control and optical monitoring of neural activity. [19][20][21][22] The processes for wirelessly transmitting and receiving data/power to and from external devices most typically rely on integrated antennas on soft elastomers. [23][24][25][26][27] The electromagnetic performance depends on the geometry, and orientation for reconfigurable antennas, [28,29] the constituent materials, the surrounding environment and the mechanical responses to applied loads. The design goals center around maximizing the stretchability and minimizing the sizes, while maintaining excellent performance and performance stability. [30][31][32][33][34] In radio-frequency engineering, an antenna acts as either a transmitter or receiver to link electromagnetic waves traveling through space to electrical currents in the conductive components. [35] The radiation pattern defines the strength of the radiated power as a function of the direction away from the antenna, to highlight the major/minor radiation peaks, and to reveal the efficiency. The directivity (i.e., preferred radiation direction) of an antenna describes the power received in its peak direction. A high directivity implies that the antenna is more likely to receive signals from a specific direction. For an isotropic antenna, the radiation pattern is equal in all directions, with zero directionality, corresponding to a directivity of 1 (or 0 dB). The ratio of the power delivered to and radiated from an antenna is known as the antenna efficiency. In the transmission process, the power can be radiated, absorbed as losses within the antenna, or reflected away due to an impedance mismatch with the transmission line. A high-efficiency antenna radiates most of the power and a low-efficiency antenna either absorbs or reflects the power causing poor transmission. The ratio of power transmitted in the preferred direction to that of an isotropic antenna is described as the antenna Combined advances in material science, mechanical engineering, and electrical engineering form the foundations of thin, soft electronic/ optoelectronic platforms that have unique capabilities in wireless monitoring and control of various biological processes in cells, tissues, and organs. Miniaturized, stretchable antennas represent an essential link between such devices and external systems for control, power...