Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats

Suyama, Hajime; Egger, Veronica; Lukas, Michael

doi:10.1038/s42003-021-02129-7

Cited by 19 publications

(9 citation statements)

References 78 publications

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“…Thus, one could hypothesize that AVP acts as a gateway, filtering inhibitory inputs in order to trigger appropriate behavioral responses. In fact, similar findings have been suggested in the olfactory system in response to social stimuli (Lukas et al 2019;Suyama et al 2021;Tobin et al 2010) (Fig. 3).…”

Section: Neurobiological Mechanismssupporting

confidence: 88%

Animal Models of Aggression

Oliveira

2023

Handbook of Anger, Aggression, and Violence

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Rodent models have been extensively used to study the neural underpinnings of aggression. Yet, the role of some external factors such as social experiences, or internal factors such as biological sex, have only recently gained attention. This chapter discusses how the composition of the social environment and/or the lack of social contact (social isolation) in different stages of development impact the display of aggressive behavior in rodents. Additionally, this chapter covers how biological sex interacts with changes in the composition of the social environment to affect the neuronal networks of aggression. From a neurobiological point of view, this chapter focuses particularly on the participation of neuroendocrine systems such as sex hormones, oxytocin, and vasopressin and on how social interactions shape brain plasticity within those systems.

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Section: Neurobiological Mechanismssupporting

confidence: 88%

Animal Models of Aggression

Oliveira

2023

Handbook of Anger, Aggression, and Violence

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“…Males seem to be more reliant on vasopressin, acting on its V1a receptor, for social recognition than females (Bredewold & Veenema, 2018;Gabor et al, 2012). Interestingly, ACh has been shown to stimulate vasopressin release in the hypothalamus, amygdala and olfactory bulb (Gregg, 1985;Hillhouse & Milton, 1989;Raber et al, 1994;Suyama et al, 2021). As we only investigated the role of cholinergic signalling in male mice, it is thus possible that the deficits in social recognition we observed result, at least in part, from decreased vasopressin release.…”

Section: Discussionmentioning

confidence: 82%

Cholinergic transmission from the basal forebrain modulates social memory in male mice

Kljakic

Al‐Onaizi

Janickova

et al. 2021

Eur J of Neuroscience

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Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter—the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of social memory and social preference. Furthermore, we demonstrated that increasing global cholinergic tone does not increase social behaviours. Together, these data suggest that cholinergic transmission from the hippocampus and cortex are important for regulating social memory.

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“…Second, as to the mechanism for heartbeat transmission reported here, fast excitatory feedback for an increased heart rate (versus the slower classical baroreflex) might facilitate adequate responses due to arousal related to, for example, the appearance of predators or social interactions. Arousal and attention-demanding tasks activate cholinergic projections ( 76 ), which in turn act both in a vasodilative manner to increase local blood flow ( 77 ) and to directly modulate neuronal activity, which is correlated with OB-based social discrimination ( 78 ). Such coincident effects—a direct increase in excitability via fast-acting OB mechanoreceptors and top-down release of neuromodulators—might summate to enhance sensory acuity during a relevant context through the modulation of brain regions that are not targeted by the classical baroreceptive afferents.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

Jammal Salameh,

Bitzenhofer,

Hanganu-Opatz

et al. 2024

Science

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The transmission of the heartbeat through the cerebral vascular system causes intracranial pressure pulsations. We discovered that arterial pressure pulsations can directly modulate central neuronal activity. In a semi-intact rat brain preparation, vascular pressure pulsations elicited correlated local field oscillations in the olfactory bulb mitral cell layer. These oscillations did not require synaptic transmission but reflected baroreceptive transduction in mitral cells. This transduction was mediated by a fast excitatory mechanosensitive ion channel and modulated neuronal spiking activity. In awake animals, the heartbeat entrained the activity of a subset of olfactory bulb neurons within ~20 milliseconds. Thus, we propose that this fast, intrinsic interoceptive mechanism can modulate perception—for example, during arousal—within the olfactory bulb and possibly across various other brain areas.

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Top-down acetylcholine signaling via olfactory bulb vasopressin cells contributes to social discrimination in rats

Cited by 19 publications

References 78 publications

Animal Models of Aggression

Animal Models of Aggression

Cholinergic transmission from the basal forebrain modulates social memory in male mice

Blood pressure pulsations modulate central neuronal activity via mechanosensitive ion channels

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