Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E<sub>2</sub> Inhibition in Femtosecond Laser-Assisted Cataract Surgery

Chenhui,; Lin, Zhuoling; ChenWan,; ZhangBo,; Xiangwu,; Lijing,; ChenWeirong,

doi:10.1089/jop.2016.0114

Cited by 21 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar result was reported in a study by Cervantes-Coste et al They found prophylactic use of nepafenac 0.1% was more effective in maintaining mydriasis as compared to control group [18]. Another study by Chen H et al showed pre-operative use of topical bromfenac sodium 0.1% in Femtosecond laser assisted cataract surgery was effective in maintaining intraoperative mydriasis as compared to control (placebo) group [19]. Many surgeons are now opting to use NSAID ophthalmic solutions preoperatively and post operatively to reduce intraoperative pain and postoperative inflammation.…”

Section: Original Research Articlesupporting

confidence: 81%

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

Minj

Satapathy

Kumar

2019

Trop J Ophthalmol Otolaryngol

View full text Add to dashboard Cite

Introduction: Intraoperative miosis is a problem which can lead to various complications that may adversely affect the outcome of cataract surgery. Topical non-steroidal anti-inflammatory drugs (NSAIDs) have been found to be helpful in reducing the intraoperative miosis. We tried to compare the effectiveness of two such molecules bromfenac and nepafenac. Objective: To compare the effectiveness of topical bromfenac (0.09%) and nepafenac (0.1%) in maintaining mydriasis and controlling immediate post-operative inflammation in cataract surgery. Methods: This is a prospective, randomised, open-label, comparative study of patients with senile cataract posted for cataract extraction and intra-ocular lens (IOL) implantation. The patients were randomised into 3 groups: topical moxifloxacilin 0.5% alone (control group or group A), topical bromfenac 0.09% + moxifloxacilin 0.5% (group B) and topical nepafenac 0.1% + moxifloxacilin 0.5% (group C). The drops were started one day before surgery. Mean pupil diameter was measured before starting surgery and after implanting IOL. Slit lamp examination was done on first postoperative day to look for anterior chamber reaction. The values were compared among the 3 groups. Results: The total loss of mean pupillary diameter was significant (p < 0.0001) in control group (25.87%) as compared to bromfenac (3.51%) and nepafenac (3.81%) group. Post-operative inflammation was significantly less (p <0.0001) in bromfenac and nepafenac group as compared to that of control group. Loss of mydriasis and post-operative inflammation was similar in both bromfenac and nepafenac group. Conclusion: Both bromfenac and nepafenac given topically prior to cataract surgery are equally effective in maintaining mydriasis during surgery as well as in controlling immediate postoperative inflammation.

show abstract

Section: Original Research Articlesupporting

confidence: 81%

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

Minj

Satapathy

Kumar

2019

Trop J Ophthalmol Otolaryngol

View full text Add to dashboard Cite

show abstract

“…Some studies report that topically applied NSAIDs are comparable to topically administered corticosteroids in their ability to control post-cataract inflammation (8-10). The study of Jung et al (11) found that adding NSAIDs (bromfenac 0.1%) to topical steroid reduces intraoperative miosis, postoperative inflammation and macular thickness changes more effectively than postoperative steroid alone (12)(13). Moreover, Coassin et al (14) ISSN 0023-2157 Index 362646…”

Section: Discussionmentioning

confidence: 99%

Comparison of efficacy and safety of postoperative treatment with loteprednol etabonate and bromfenac after phacoemulsification

Kucharczyk-Pospiech¹,

Jurowski²,

Kubisiak³

et al. 2019

View full text Add to dashboard Cite

Aim: Comparison of efficacy and safety of loteprednol etabonate and bromfenac after phacoemulsification. Material and Methods: Multicenter prospective case series. Consecutive 58 patients (58 eyes) were randomly assigned to the one of the study groups regarding postoperative treatment. Patients in Group I used 0.09% bromfenac 2 times diurnally for 30 days, and patients in Group II used 0.5% loteprednol etabonate 4 times diurnally for 30 days. The laser flare-cell photometry, slit lamp examination, tonometry and optical coherence tomography of macula were performed preoperatively and postoperatively at 1, 7, 30 and 90 days. Results: The distance best corrected visual acuity was 0. 93 in group I and 0.91 in w group II. Laser Flare Photometry, central macular thickness and intraocular pressure was not significantly different during the 3 months of treatment between the groups (p> 0.05). In both groups, there were no abnormalities in routine slit lamp examination of the anterior and posterior segment. Conclusions: The results of the study suggest that topical bromfenac and topical loteprednol etabonate had similar effect on laser flare-cell photometry and foveal thickness in the postoperative period after uneventful phacoemulsification.

show abstract

“…Un recente studio condotto in 60 pazienti sottoposti a chirurgia della cataratta con femto-laser, trattati con bromfenac 0,1% 2 volte al giorno, per 3 giorni prima dell'intervento, ha dimostrato che la variazione del diametro pupillare è inferiore nei pazienti trattati con bromfenac rispetto ai controlli trattati con placebo, con una riduzione significativa dei livelli di PGE2 (Fig. 10) [13].…”

Section: Prevenzione Della Miosi Intraoperatoriaunclassified

“…10-Variazioni del diametro pupillare e livelli medi di PGE2 nell'umore acqueo dei pazienti trattati con bromfenac o placebo. *p < 0,001 (modificata da[13])…”

unclassified

Inflammation management in ophthalmology: new evidences for cataract surgery and beyond

Piovella¹,

Avitabile

Bellucci

et al. 2019

abtpn

View full text Add to dashboard Cite

Inflammation represents the manifestation of the host's vascular and cellular response to tissue damage, hypersensitivity of the immune system or autoimmunity. As soon as the damage is detected, the mechanisms of localization and removal of foreign substances and damaged tissues are triggered. This response is amplified by the activation of inflammatory cells and by the production of chemical mediators derived from arachidonic acid, vasoactive substances and cytokines.At the ocular level, among the different responses implemented by various inflammation mediators, the action of prostaglandins is mainly expressed in three ways: i) change of intraocular pressure; ii) induction of miosis; iii) increase of protein concentration in the aqueous humor.Ocular inflammation may continue long after the cessation of the initial cause and may also lead to serious consequences, including permanent vision reduction. For this reason, it is essential to establish a correct and effective therapeutic strategy, which allows to control inflammation, the symptoms and the clinical signs associated with it.This article therefore deals with therapeutic strategies to control inflammation, with a particular focus on the role of nonsteroidal anti-inflammatory drugs (NSAIDs) in cataract surgery.

show abstract

Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E₂ Inhibition in Femtosecond Laser-Assisted Cataract Surgery

Abstract: NSAID treatment, when administered before femtosecond laser-assisted cataract surgery, was effective in maintaining intraoperative pupil dilation, preventing miosis, and reducing PGE levels.

Cited by 21 publications

References 37 publications

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

Comparison of efficacy and safety of postoperative treatment with loteprednol etabonate and bromfenac after phacoemulsification

Inflammation management in ophthalmology: new evidences for cataract surgery and beyond

Contact Info

Product

Resources

About

Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E2 Inhibition in Femtosecond Laser-Assisted Cataract Surgery

Abstract: NSAID treatment, when administered before femtosecond laser-assisted cataract surgery, was effective in maintaining intraoperative pupil dilation, preventing miosis, and reducing PGE levels.

Cited by 21 publications

References 37 publications

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

The importance of preoperative topical non-steroidal antiinflammatory agents in cataract surgery- an open label prospective randomised comparative study

Comparison of efficacy and safety of postoperative treatment with loteprednol etabonate and bromfenac after phacoemulsification

Inflammation management in ophthalmology: new evidences for cataract surgery and beyond

Contact Info

Product

Resources

About

Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E₂ Inhibition in Femtosecond Laser-Assisted Cataract Surgery