Topical 5-fluorouracil application in management of odontogenic keratocysts

Comparison of the effectiveness of 5-Fluorouracil and modified Carnoy's solution in reducing the recurrence of odontogenic keratocyst

“…The higher recurrence rate in the 5-FU group could be due to the longer follow up period of 7 years . 16 …”

Combined conservative treatment of a recurrent mandibular keratocyst by enucleation, diode laser, 5-Fluorouracil and dental implants: a case report with 18 years-follow up

“…Akhter Lone et al (2020) investigated the usefulness of 5-FU in OKC. For them, when applied topically in OKC, it induced less postoperative morbidity than enucleation followed by application of MCS [16]. Isola et al (2017) showed that the use of diode laser in the treatment of lateral periodontal cyst accelerates healing time and could be adopted for surgical treatment for the epithelial developmental odontogenic cysts [14].…”

“…Akhter Lone et al (2020) investigated the usefulness of 5-FU in OKC. For them, when applied topically in OKC, it induced less postoperative morbidity than enucleation followed by application of MCS [ 16 ].…”

Review of 5-Fluorouracil is Associated With a Decreased Recurrence Risk in Odontogenic Keratocyst Management: A Retrospective Cohort Study

“…Although patients may experience pain, swelling, and/or discharge, most are asymptomatic and lesions are found on routine dental examinations and radiographs in which OKCs present as unilocular or multilocular radiolucencies. 4 Histopathologically, the OKC's cystic lining is characterized by a thin, 6-to 10-cell layer-thick stratified squamous epithelium with parakeratinization. 1 There is a lack of rete pegs, creating a flat epithelialconnective tissue interface.…”

“…The efficacy of 5-FU in the treatment of OKCs has been attributed to the similarities of basal cell carcinoma to OKCs in molecular etiopathogenesis. 4 A consideration when using 5-FU, or any chemical cautery therapy in OKC treatment, is the potential deleterious effect on adjacent nerve tissue, leading to temporary or permanent neurosensory deficit.…”