Topical and oral treatments for fungal skin infections

Healy, Brendan; Barnes, Rosemary Anne

doi:10.1002/psb.360

Cited by 5 publications

(6 citation statements)

References 21 publications

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“…37 People's eating habits and lifestyles are changing these days; they are consuming junk food, which increases the risk of numerous ailments. Ketoconazole Hepatotoxicity [19] Miconazole Liver damage, nausea, arrhythmias, pruritus, hyponatraemia, hyperlipidaemia, dyscrasias [34] Azoles (Triazoles)…”

Section: Herbal Curementioning

confidence: 99%

Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

Sharma

Gupta

2022

Health Science Reports

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Background and Aims Fungal dermatophytosis or Tinea is a predominance in about 20%–25% of all total world populations. Dermatophyte infections are mainly caused by fungi belonging to Trichophyton, Epidermophyton, and Microsporum genera along with some other fungi. This epidemiological distribution may change with migration, lifestyle, immunosuppressive state, drug therapy, and socioeconomic conditions. Methods The present review indicated the bioefficacy of herbal and herbonanoconjugate as safe management of fungal dermatophytic infection. Results It also emphasized the action mechanism as fungicidal and fungistatic with different harmful impacts indicating the need for alternative therapeutics. Simultaneously, the herbal and herbonanoconjugate approaches proved better to manage the prevalence of hepatotoxicity, nephrotoxicity, nausea, altered taste, anemia, GI upsets, hair loss, and so forth. due to conventional oral treatment approaches. Conclusion Adoption of the remedial approach can be recommended after preclinical trials' approval as a safe treatment.

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Section: Herbal Curementioning

confidence: 99%

Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

Sharma

Gupta

2022

Health Science Reports

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“…3,4 Oral antifungal agents are the primary and most effective treatment for cutaneous fungal infections, especially for widespread and difficult to cure disease. 5,6 The increasing reports of treatment failures and high recurrence rates are concerning, especially because of the limited alternative therapies for fungal infections. 7,8 In a hospital-based study in France, Nivoix et al reported that 40% of antifungals prescribed for systemic mycoses were used inappropriately with respect to indication, dosage, antifungal susceptibility test results, or risk of adverse events.…”

Section: Introductionmentioning

confidence: 99%

“…12 Decades of this overuse and misuse of antifungals may have facilitated the emergence and global spread of antifungal resistance. 5,6,13,14 While there is widespread global acceptance and awareness of antimicrobial stewardship (AMS), which primarily focuses on bacterial infections, antibiotic use, and rising antibacterial resistance, antifungal stewardship (AFS) focusing on antifungal use and antifungal resistance is comparatively less established.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, invasive fungal infections are becoming more frequent owing to a growing immunocompromised population and the emergence of new fungal species 3,4 . Oral antifungal agents are the primary and most effective treatment for cutaneous fungal infections, especially for widespread and difficult to cure disease 5,6 . The increasing reports of treatment failures and high recurrence rates are concerning, especially because of the limited alternative therapies for fungal infections 7,8 …”

Section: Introductionmentioning

confidence: 99%

“…Most studies across the globe report administration of antifungal agents as prophylaxis or combination therapy without any proper direction, indication, or supporting evidence 12 . Decades of this overuse and misuse of antifungals may have facilitated the emergence and global spread of antifungal resistance 5,6,13,14 …”

Section: Introductionmentioning

confidence: 99%

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The increasing problem of treatment‐resistant fungal infections: a call for antifungal stewardship programs

et al. 2021

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Antimicrobial stewardship (AMS) programs have been widely recognized among the public health community. These programs focus majorly on bacterial infections, efficient antibiotic use, and measures to curb increasing antibacterial resistance. AMS programs are successfully established around the globe; however, very few include antifungal stewardship (AFS). The increasing incidence of superficial and invasive fungal infections, combined with delayed or inaccurate diagnosis, has contributed to the overprescribing and overuse of antifungal agents. Such increased exposure to antifungal agents may be a reason for the emergence of increasing antifungal resistance among fungal pathogens. With mounting reports of treatment failures and resistant infections, the evidence to support the need for AFS programs is increasing. AFS is an emerging branch of AMS programs that requires global attention and recognition.

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Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans

Bhaskaran

Salwa

Fernandes

et al. 2022

Tenside Surfactants Detergents

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The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.

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Topical and oral treatments for fungal skin infections

Cited by 5 publications

References 21 publications

Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

The increasing problem of treatment‐resistant fungal infections: a call for antifungal stewardship programs

Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans

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