Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

Sharma, Anusha; Gupta, Sarika

doi:10.1002/hsr2.775

Cited by 10 publications

(6 citation statements)

References 69 publications

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“…Furthermore, dermatophytes often lead to skin lesions [ 26 ]. Therefore, wound healing is needed to regenerate the damaged tissue; otherwise, the wound becomes chronic [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil

Alves-Silva

Maccioni

Cocco

et al. 2023

Plants

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The Salvia L. genus (Lamiaceae) is largely used in the pharmaceutical and food industry. Several species of biological relevance are extensively employed in traditional medicine, including Salvia aurea L. (syn. S. africana-lutea L.), which is used as a traditional skin disinfectant and in wounds as a healing remedy; nevertheless, these properties have not been validated yet. The aim of the present study is to characterise S. aurea essential oil (EO), unveiling its chemical composition and validating its biological properties. The EO was obtained by hydrodistillation and subsequently analysed by GC-FID and GC-MS. Different biological activities were assessed: the antifungal effect on dermatophytes and yeasts and the anti-inflammatory potential by evaluating nitric oxide (NO) production and COX-2 and iNOS protein levels. Wound-healing properties were assessed using the scratch-healing test, and the anti-aging capacity was estimated through the senescence-associated beta-galactosidase activity. S. aurea EO is mainly characterised by 1,8-cineole (16.7%), β-pinene (11.9%), cis-thujone (10.5%), camphor (9.5%), and (E)-caryophyllene (9.3%). The results showed an effective inhibition of the growth of dermatophytes. Furthermore, it significantly reduced protein levels of iNOS/COX-2 and simultaneously NO release. Additionally, the EO exhibited anti-senescence potential and enhanced wound healing. Overall, this study highlights the remarkable pharmacological properties of Salvia aurea EO, which should be further explored in order to develop innovative, sustainable, and environmentally friendly skin products.

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“…Furthermore, dermatophytes often lead to skin lesions [ 26 ]. Therefore, wound healing is needed to regenerate the damaged tissue; otherwise, the wound becomes chronic [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil

Alves-Silva

Maccioni

Cocco

et al. 2023

Plants

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“…Considering that dermatophyte infection can lead to the formation of skin lesions [ 8 ], we assessed whether S. cacaliifolia could promote wound healing. Our results showed that this essential oil promotes the migration of fibroblasts, thus suggesting that it might play a role in the wound healing process.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, dermatophytes are associated with the formation of skin lesions [ 8 ]. Therefore, after the resolution of an infection, wound healing processes must occur in order to regenerate the damaged tissue.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

Alves-Silva

Cocco

Piras

et al. 2023

Plants

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Salvia is widely recognized for its therapeutic potential. However, the biological relevance of some species remains unknown, namely Salvia cacaliifolia Benth. Therefore, the aim of this study is to unveil the chemical composition and relevant properties to its essential oil (EO). The EO was characterized by GC and GC-MS and its antifungal effect was evaluated according to the CLSI guidelines on dermatophytes and yeasts. The anti-inflammatory potential was assessed on lipopolysaccharide-stimulated macrophages, by assessing the production of nitric oxide (NO) and the effect on the protein levels of two key pro-inflammatory enzymes, iNOS and COX-2 by western blot analysis. Wound healing capacity was determined using the scratch wound healing assay, and the anti-aging potential was assessed by evaluating the senescence marker β-galactosidase. The EO was mainly characterized by γ-curcumene, β-bisabolene, bicyclogermacrene and curzerenone. It is effective in inhibiting the growth of dermatophytes and C. neoformans. The EO significantly decreased iNOS and COX-2 protein levels and concomitantly reduced NO release. Additionally, it demonstrated anti-senescence potential and promoted wound healing. Overall, this study highlights relevant pharmacological properties of the EO of Salvia cacaliifolia, which should be further explored envisaging the development of sustainable, innovative, and environmentally friendly skin products.

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“…They have developed a regenerative medicine formulation that combines synergistic herbal components. The product is a combination of therapeutically effective extracts of Curcuma longa , Glycyrrhiza glabara , Hamiltonia suaveolens , Tipha angustifolia and Azadirachta indica as well as an optional base of Pig fat in Sesamum indicum (Til) oil [ 113 ].…”

Section: Biopolymer-based Nanomaterials For Successful Wound Treatmentmentioning

confidence: 99%

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

et al. 2023

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Globally, millions of people suffer from poor wound healing, which is associated with higher mortality rates and higher healthcare costs. There are several factors that can complicate the healing process of wounds, including inadequate conditions for cell migration, proliferation, and angiogenesis, microbial infections, and prolonged inflammatory responses. Current therapeutic methods have not yet been able to resolve several primary problems; therefore, their effectiveness is limited. As a result of their remarkable properties, bio-based materials have been demonstrated to have a significant impact on wound healing in recent years. In the wound microenvironment, bio-based materials can stimulate numerous cellular and molecular processes that may enhance healing by inhibiting the growth of pathogens, preventing inflammation, and stimulating angiogenesis, potentially converting a non-healing environment to an appropriately healing one. The aim of this present review article is to provide an overview of the mechanisms underlying wound healing and its pathophysiology. The development of bio-based nanomaterials for chronic diabetic wounds as well as novel methodologies for stimulating wound healing mechanisms are also discussed.

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Protective manifestation of herbonanoceuticals as antifungals: A possible drug candidate for dermatophytic infection

Cited by 10 publications

References 69 publications

Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil

Advances in the Phytochemical Characterisation and Bioactivities of Salvia aurea L. Essential Oil

Unveiling the Chemical Composition and Biological Properties of Salvia cacaliifolia Benth. Essential Oil

A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

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