Topical anti-inflammatory activity of Gentianella achalensis

Nadinic, Elena L.; Gorzalczany, Susana; Rojo, Alicia; Baren, Catalina M. van; Debenedetti, Sílvia; Acevedo, Cristina

doi:10.1016/s0367-326x(99)00020-9

Cited by 26 publications

(19 citation statements)

References 14 publications

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“…In the traditional medicine of South America, Gentianella preparations are used for treatment of digestive and liver problems (Nadinic et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Propagation and xanthone content of Gentianella austriaca shoot cultures

Vinterhalter¹,

Janković

Šavikin

et al. 2008

Plant Cell Tiss Organ Cult

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Shoot cultures of Gentianella austriaca (A. & J. Kerner) Dostal established from seedling epicotyls were maintained on MS medium supplemented with 2.22 lM BA and 0.54 lM NAA. A characteristic feature of these cultures was precocious flowering, which appeared in all rapidly elongating shoots. Flower development arrested shoot elongation and multiplication of shoot cultures. Continuous shoot propagation was possible only by use of small axillary or adventitious buds as explants for subculturing. Flowering could not be suppressed by GA 3 addition or by cultivation in short-day conditions. The highest rooting percentage (47.3% with 7.83 roots per explant) was achieved on media with 4.92 lM IBA. Shoot cultures contained the same types of secondary metabolites as plants from nature. Xanthones were the major constituents, with DMB (demethylbellidifolin), DGL (demethylbellidifolin-8-O-glucoside) and BGL (bellidifolin-8-O-glucoside) present at roughly two times lower concentrations than in samples from nature. Secondary metabolite production was strongly affected by the presence of BA in the medium.

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“…In the traditional medicine of South America, Gentianella preparations are used for treatment of digestive and liver problems (Nadinic et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Propagation and xanthone content of Gentianella austriaca shoot cultures

Vinterhalter¹,

Janković

Šavikin

et al. 2008

Plant Cell Tiss Organ Cult

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“…In the traditional medicine of South America, Gentianella preparations are used to treat digestive and liver problems (Lacaille-Dubois et al 1996;Nadinic et al 1999) and obesity (Rojas et al 2004). In folk medicine of the Balkan area, Gentianella species are often used as substitutes for the related Gentiana species, G. lutea and G. punctata.…”

Section: Secondary Metabolitesmentioning

confidence: 99%

Biotechnology and Phytochemistry of Gentianella Species from the Central Regions of the Balkan Peninsula

Krstić-Milošević

Vinterhalter

Janković

et al. 2015

The Gentianaceae - Volume 2: Biotechnology and Applications

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In the central regions of the Balkan Peninsula, the genus Gentianella is represented by six species. Five of them G. albanica, G. austriaca, G. bulgarica, G. ciliata, and G. crispata were subject of phytochemical and in vitro studies. Two species, G. austriaca and G. bulgarica, were established as shoot cultures and procedures developed for their in vitro propagation. Difficulties with seed germination and precocious flowering affected the final propagation stages. Phytochemical analyses were performed on five species from nature and on cultured shoots. Plant material was rich in secondary metabolites with xanthones, flavone-C-glucosides, and secoiridoids as the principal constituents. The xanthone aglycones, demethybellidifolin, bellidifolin, corymbiferin, and their corresponding glucosides were dominant components in all the species investigated. The predominant substitution pattern of xanthones found in the genus Gentianella was 1,3,5,8 and to a lesser extent, 1,3,7,8. Lanceoside and veratriloside were new compounds found in European Gentianella species. In vitro material generally contained less secondary metabolites than plants from nature; the content of secondary products was influenced by the concentration of benzyladenine (BAP) in the culture medium.

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“…Gentianella species have been used in the traditional medicine of South America as substitutes of Gentiana preparations for the treatment of digestive and liver problems (Lacaille-Dubois et al 1996;Nadinic et al 1999). Xanthones, C-glucoflavones, and secoiridoids are the main secondary metabolites of the genus (Hostettmann-Kaldas et al 1981).…”

Section: Introductionmentioning

confidence: 99%

Xanthone compounds in shoot cultures of Gentianella bulgarica

Janković¹,

Vinterhalter

Krstić-Milošević

et al. 2011

Acta Physiol Plant

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Shoot cultures of Gentianella bulgarica established from seedling epicotyls were maintained on MS medium supplemented with BA 0.2 mg l -1 ? NAA 0.1 mg l -1 . Cultures were prone to precocious flowering requiring the use of small shoot buds for multiplication purposes. The contents of three xanthone compounds identified as DGL, BGL, and DMB, in different plant material were determined by HPLC. The analysis revealed that the production of xanthones was affected by different concentrations of BA in medium. Shoot cultures grown at higher BA concentrations contained more DGL than material grown in nature. The concentrations of other two xanthones were lower in shoot cultures than in plants from nature. The radical scavenging activity of plant extracts and xanthones was investigated by DPPH test. Samples from plants grown in nature showed the highest activity (IC 50 = 0.26 mg ml -1 ), while the extracts of shoot cultures grown in media with higher concentrations of BA showed moderate activities (IC 50 from 1.6 to 4.4 mg ml -1 ).

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Topical anti-inflammatory activity of Gentianella achalensis

Cited by 26 publications

References 14 publications

Propagation and xanthone content of Gentianella austriaca shoot cultures

Propagation and xanthone content of Gentianella austriaca shoot cultures

Biotechnology and Phytochemistry of Gentianella Species from the Central Regions of the Balkan Peninsula

Xanthone compounds in shoot cultures of Gentianella bulgarica

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