Topical antioxidants protect the skin from chemical‐induced irritation in the repetitive washing test: a placebo‐controlled, double‐blind study

Schempp, Christoph M.; Meinke, Martina C.; Lademann, Jürgen; Ferrari, Yvonne; Brecht, Th.; Gehring, W.

doi:10.1111/j.1600-0536.2012.02114.x

Cited by 22 publications

(17 citation statements)

References 14 publications

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“…The best effect was achieved with the antioxidant containing cream, whereas the untreated skin showed the worst results. Other studies with creams containing antioxidants also showed positive skin effects with respect to contact allergies and contact dermatitis [67][68][69][70].…”

Section: Effect Of Topical Applicationmentioning

confidence: 99%

“…Schempp et al studied the effect of an antioxidant-containing cream, a base and barrier protection cream on untreated skin in order to analyze the hydration of the SC and the blood flow by a chemically induced contact dermatitis [67]. The best effect was achieved with the antioxidant containing cream, whereas the untreated skin showed the worst results.…”

Section: Effect Of Topical Applicationmentioning

confidence: 99%

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Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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Organisms produce free radicals which are essential for various metabolic processes (enzymatic oxidation, cellular respiration, signaling). Antioxidants are important chemical compounds that specifically prevent the oxidation of substances by scavenging radicals, especially reactive oxygen species (ROS). Made up of one or two unpaired electrons, ROS are free radicals that are highly reactive and can attack other metabolites. By using electron paramagnetic resonance (EPR) spectroscopy, it is possible to measure paramagnetic substances such as free radicals. Therefore the dermal antioxidant activity can be determined by applying semi-stable radicals onto the skin and measuring the antioxidant-induced radical scavenging activity in the skin. In recent years, EPR has been OPEN ACCESS Cosmetics 2015, 2 287 developed as a spectroscopic method for determining the antioxidant status in vivo. Several studies have shown that an additional uptake of dietary supplements, such as carotenoids or vitamin C in physiological concentrations, provide a protective effect against free radicals. Using the EPR technique it could be demonstrated that the radical production in stress situations, such as irradiation with infrared and visible light, was reduced with time. However, not only the oral uptake of antioxidants, but also the topical application of antioxidants, e.g., a hyperforin-rich cream, is very useful against the development of oxidative stress. Regular application of a hyperforin-rich cream reduced radical formation. The skin lipids, which are very important for the barrier function of the skin, were also stabilized.

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Section: Effect Of Topical Applicationmentioning

confidence: 99%

Section: Effect Of Topical Applicationmentioning

confidence: 99%

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

et al. 2015

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“…On the other hand, application of vitamin E after SLS shortened the recovery time, as shown by its effects on TEWL, detached corneocytes, targetoid keratinocytes at the epidermis and at the dermis, and papillary shape irregularity reduction, as compared with the control site ( Fig. 4) (19). CONFOSCAN ® evaluation suggests that vitamin E prevents skin irritation and also stimulates repair mechanisms after irritating phenomena.…”

Section: Discussionmentioning

confidence: 94%

In vivo assessment of cytological changes by means of reflectance confocal microscopy – demonstration of the effect of topical vitamin E on skin irritation caused by sodium lauryl sulfate

et al. 2016

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“…This positive effect of topical HA could be linked to its skin hydrating action [25] and skin barrier function improvement [26]. Topical HA could exert also anti-oxidant activity [27]. In addition, topical HA can modulate several skin cells functions: topical HA can have relevant effects on cell proliferation, recognition, and cell migration [28].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of a Corticosteroid-Free, 5% Hyaluronic-Based Facial Cream in the Treatment of Seborrheic Dermatitis. A Proof-of-Concept Study

Milani¹,

Barcella²,

Puviani³

2017

J Clin Exp Dermatol Res

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Introduction: Seborrheic Dermatitis (SD) is a very common skin disease. This papulo-squamous disorder characterized by erythema, itch, and flaking, affects sebum-rich areas such as scalp, trunk and face. Topical steroids are commonly used as first line therapy of SD but their long-term use, especially when face is involved, could have untoward side effects like skin atrophy, acne and telangiectasia. Local tolerability and long-term safety concerns limit the use of calcineurin inhibitors. Hyaluronic acid topical formulations, thanks to its hydrating and several skin cellular modulation effects have shown to reduce skin inflammation and improve the clinical course of SD. A new cream formulation of HA 5% (Eutrosis DS, Difa Cooper, IFC Group; EDS) has been recently developed.

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Topical antioxidants protect the skin from chemical‐induced irritation in the repetitive washing test: a placebo‐controlled, double‐blind study

Abstract: The superiority of the cream with antioxidants to the cream base suggests that reactive oxygen species, at least in part, play a role in the development of irritant contact dermatitis.

Cited by 22 publications

References 14 publications

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

Determination of the Antioxidant Status of the Skin by In Vivo-Electron Paramagnetic Resonance (EPR) Spectroscopy

In vivo assessment of cytological changes by means of reflectance confocal microscopy – demonstration of the effect of topical vitamin E on skin irritation caused by sodium lauryl sulfate

Efficacy of a Corticosteroid-Free, 5% Hyaluronic-Based Facial Cream in the Treatment of Seborrheic Dermatitis. A Proof-of-Concept Study

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