Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

“…Previous studies have pointed out the importance of Th1 and Th2 cytokines, which are found to be overexpressed on the skin as means of inflammatory response on experimental models of allergen-induced allergic inflammation in mice [5]. Moreover, after the DfE application, Th1, Th2, and proinflammatory cytokines were increased in concentration as demonstrated by the study of Sung and colleagues [20]. Here, we investigated the effect of drinking HW on serum cytokines (Th1, Th2 and pro-inflammatory) using Luminex-bead array system known for its high sensitivity and precision.…”

Illicium verum extract suppresses IFN-γ-induced ICAM-1 expression via blockade of JAK/STAT pathway in HaCaT human keratinocytes

“…Topical application of IVE in mite antigen-induced AD mice showed remarkable anti-allergic efficacy (Sung et al, 2012b). These results indicate that IVE may also exhibit this effect on Th1-mediated skin inflammation, such as psoriasis and contact dermatitis.…”

“…From the previous HPLC analysis, it was confirmed that IVE contains 6.14% p-anisaldehyde and 1.98% trans-anethole as main constituents (Sung et al, 2012b), indicating that the amount of anisaldehyde and anethole was equal to 3.07 μg/ml and 0.99 μg/ml, respectively, in 50 μg/ml of IVE. It is notable that p-anisaldehyde and trans-anethole individually produced similar degree of inhibition in ICAM-1 expression and adherence of T cells at the same concentration to IVE tested in this work (Figs.…”

“…The fruits of Illicium verum are commonly used as a spice and traditional medicine for treating stomach ailments, colic, vomiting, skin inflammation, asthma, and rheumatic pain in eastern Asia (Chouksey et al, 2010;Editorial Committee of Chinese Pharmacopoeia, 2010;Wang et al, 2011). Our previous studies demonstrated that Illicium verum extract (IVE) exerts anti-inflammatory effects by suppressing cytokines, chemokines, and adhesion molecules in TNF-α/IFN-γ-stimulated HaCaT keratinocytes and atopic dermatitis (AD)-like skin lesions of a house mite antigen-induced AD mouse strain (Sung et al, 2012a(Sung et al, , 2012b. However, the mechanism underlying these inhibitory outcomes remains unclear.…”

“…However, the mechanism underlying these inhibitory outcomes remains unclear. Our previous study identified p-anisaldehyde and trans-anethole as the two major constituents of IVE, with each component constituting 6.14% anisaldehyde and 1.98% anethole (Sung et al, 2012b). Anethole has been reported to exert anti-inflammatory effects by suppressing nitric oxide, prostaglandin E 2 , and cytokines in lipopolysaccharide-stimulated RAW 264.7 macrophages (Conforti et al, 2010).…”