Topical Application of Arnica and Mucopolysaccharide Polysulfate Attenuates Periorbital Edema and Ecchymosis in Open Rhinoplasty

Şimşek, Gökçe; Sarı, Elif; Kılıç, Rahmi; Muluk, Nuray Bayar

doi:10.1097/01.prs.0000479967.94459.1c

Cited by 38 publications

(32 citation statements)

References 14 publications

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“…For example, oral administrations of heparinoid are effective in the treatment of oral lichen planus . Moreover, topical heparinoid‐containing cream not only reduces postoperative ecchymosis and oedema, but also prevents the development of pressure ulcers . Furthermore, topical applications of a heparinoid‐containing product significantly increased stratum corneum hydration in both young and aged humans, as well as both epidermal growth factor receptor inhibitor‐ and radiotherapy‐induced skin dryness .…”

Section: Introductionmentioning

confidence: 99%

A topical heparinoid‐containing product improves epidermal permeability barrier homeostasis in mice

Yao

Guo

Feng

et al. 2019

Experimental Dermatology

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Because of the importance of epidermal functions, including stratum corneum hydration and maintenance of permeability barrier homeostasis, in the pathogenesis of a variety of cutaneous and systemic disorders, a wide range of products has been developed to improve epidermal functions. However, the underlying mechanisms whereby certain products, including heparinoid‐containing product, are far little understood. In the present study, we assessed the impact of a heparinoid‐containing product, Hirudoid® cream, on epidermal permeability barrier function and expression levels of a panel of epidermal mRNA related to the formation/maintenance of the permeability barrier in mouse skin. Our results showed that while the baseline levels of transepidermal water rates remained unchanged, treatment with Hirudoid® cream twice daily for 7 days significantly accelerated permeability barrier recovery and increased stratum corneum hydration. In parallel, expression levels of epidermal mRNA for certain differentiation marker‐related proteins, lipid synthetic enzymes, keratinocyte proliferation and antimicrobial peptides also increased significantly. Together, these results provide the underlying mechanisms by which topical Hirudoid® cream improves epidermal permeability barrier and antimicrobial function. Because of its benefits for epidermal functions, heparinoid‐containing product could be more useful in the management of skin conditions, characterized by abnormal permeability barrier and antimicrobial function.

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Section: Introductionmentioning

confidence: 99%

A topical heparinoid‐containing product improves epidermal permeability barrier homeostasis in mice

Yao

Guo

Feng

et al. 2019

Experimental Dermatology

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“…Of the 11 level II evidence studies, 3 (27%) failed to elicit significant differences between treatment and control groups at their primary end points, whereas 8 (73%) showed significant benefits. Reproducible level II studies 14,16 support the use of arnica in rhinoplasty patients for reduction in early postoperative ecchymosis and edema. Similarly, reproducible level II evidence [17][18][19][20] supports the use of onion extract for improvement in scar pigmentation.…”

Section: Resultsmentioning

confidence: 88%

Integrative Medicine in Plastic Surgery

Ruan¹,

Chen²,

Tran³

et al. 2019

Ann Plast Surg

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Background: Surveys have reported that as high as 80% of plastic surgery patients utilize integrative medicine approaches including natural products (NPs) and mind-body practices (MBPs). Little is known regarding the evidence of benefit of these integrative therapies specifically in a plastic surgery patient population. Methods: We conducted a systematic review of studies in MEDLINE, PubMed, and EMBASE (inception through December 2016) evaluating integrative medicine among plastic surgery patients. Search terms included 76 separate NP and MBP interventions as listed in the 2013 American Board of Integrative Health Medicine Curriculum. Two independent reviewers extracted data from each study, including study type, population, intervention, outcomes, conclusions (beneficial, harmful, or neutral), year of publication, and journal type. Level of evidence was assessed according to the American Society of Plastic Surgeons Rating Levels of Evidence and Grading Recommendations. Results: Of 29 studies analyzed, 13 studies (45%) evaluated NPs and 16 (55%) studied MBPs. Level II reproducible evidence supports use of arnica to decrease postoperative edema after rhinoplasty, onion extract to improve scar pigmentation, hypnosis to alleviate perioperative anxiety, and acupuncture to improve perioperative nausea. Level Vevidence reports on the risk of bleeding in gingko and kelp use and the risk of infection in acupuncture use. After year 2000, 92% of NP studies versus 44% of MBP studies were published (P = 0.008). Conclusions: High-level evidence studies demonstrate promising results for the use of both NPs and MBPs in the care of plastic surgery patients. Further study in this field is warranted.

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“…A study performed by Koşucu et al reported that keeping intraoperative mean arterial blood pressure at 50-60 mmHg reduced edema and ecchymosis (15). There are some studies about topical administration of arnica and mucopolysaccharide polysulfide cream, which reduces edema and ecchymosis (16).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of adhesive strips to reduce postoperative periorbitaledema and ecchymosis following rhinoplasty

Tatar¹,

Bulam²,

Özmen³

2018

Turk J Med Sci

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Background/aim: Periorbital edema and ecchymosis may develop following rhinoplasty. The aim of this study was to assess the efficacy of adhesive strip application on the upper and lower eyelids to reduce postoperative edema and ecchymosis following rhinoplasty. Materials and methods: The eyelids of one side were randomly selected, and an adhesive strip of standard size and number was applied at the end of the operation. The strips were removed at postoperative day 3; photos of the eyes were taken at days 3 and 7. Edema and ecchymosis were graded on a scale from 1 to 4. The ecchymosis areas on the lower and upper eyelids were measured and compared in square centimeters. Results: The mean ecchymosis area of the lower eyelid on the side of the adhesive strip and on the side without the strip was 1.63 cm2 and 3.32 cm2 in the early period, respectively. It was 1.15 cm2 on the upper eyelid on the side of the adhesive strip, and 1.87 cm2 on the side without the strip. It was 0.224 cm2 on the side of the adhesive strip, and 0.498 cm2 on the side without the adhesive strip in the late period. Conclusion: Applying adhesive strips reduces periorbital edema and ecchymosis.

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Topical Application of Arnica and Mucopolysaccharide Polysulfate Attenuates Periorbital Edema and Ecchymosis in Open Rhinoplasty

Abstract: Therapeutic, II.

Cited by 38 publications

References 14 publications

A topical heparinoid‐containing product improves epidermal permeability barrier homeostasis in mice

A topical heparinoid‐containing product improves epidermal permeability barrier homeostasis in mice

Integrative Medicine in Plastic Surgery

Efficacy of adhesive strips to reduce postoperative periorbitaledema and ecchymosis following rhinoplasty

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