Topical Application of Bacitracin Ointment Is Associated with Decreased Risk of Mediastinitis after Median Sternotomy

MacIver, Robroy; Stewart, Robert W.; Frederiksen, James W.; Fullerton, David A.; Horvath, Keith A.

doi:10.1532/hsf98.20051187

Cited by 12 publications

(9 citation statements)

References 32 publications

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“…24 Other strategies that may aid in reducing SWI rates include strict glucose management, nasopharyngeal decontamination with mupirocin, skin decontamination with chlorhexidine showers, and topical application of antibiotics (ie, bacitracin or vancomycin) postoperatively. 25,26…”

Section: Discussionmentioning

confidence: 99%

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

Mavros

Mitsikostas

Alexiou

et al. 2012

The Journal of Thoracic and Cardiovascular Surgery

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Section: Discussionmentioning

confidence: 99%

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

Mavros

Mitsikostas

Alexiou

et al. 2012

The Journal of Thoracic and Cardiovascular Surgery

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“…As a toxic and difficult‐to‐use antibiotic, bacitracin does not work well orally. However, it is very effective topically (13). Its action is on gram positives as Staphylococci and Streptococci.…”

Section: Antibiotics Available For Topic Use In Dermatologymentioning

confidence: 99%

Local antibiotics in dermatology

Gelmetti

2008

Dermatologic Therapy

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Although the vast majority of skin infection must be treated with systemic antibiotics, topical antibiotics are used overwhelmingly in the world, often as self-prescribed medications without taking into account the sensitivity of the presumed bacteria. Dermatologists are aware that different types of topical antibiotics kill different species of bacteria and tend to be more specific in their prescriptions. At present local antibiotics are advised to treat minor superficial uncomplicated skin infections (e.g., impetigo) and to prevent bacterial infections caused into minor cuts, scrapes, and burns. The role of topical antibiotics in the management of acne and atopic dermatitis is controversial. Retapamulin, a novel topical antibacterial agent, will probably replace the use of the old mupirocin and fusidic acid.

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“…It is synthesized non-ribosomally by the large multienzyme complex BacABC (24). Bacitracin is directed primarily against gram-positive bacteria via inhibition of cell wall (5, 28). Bacitracin consists of a mixture of structurally similar polypeptides from 12 amino acids (22).…”

Section: Introductionmentioning

confidence: 99%

“…It is one of the most important antibiotics used in human medicine, topical application and used after surgical operations (23, 28). Bacitracin is also commonly used in animal and poultry feed additives which increases feed efficiency and reduce infectious diseases (14, 34).…”

Section: Introductionmentioning

confidence: 99%

Systematic mutagenesis method for enhanced production of bacitracin by Bacillus licheniformis mutant strain UV-MN-HN-6

Aftab¹,

Haq²,

Baig³

2012

Braz. J. Microbiol.

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The purpose of the current study was intended to obtain the enhanced production of bacitracin by Bacillus licheniformis through random mutagenesis and optimization of various parameters. Several isolates of Bacillus licheniformis were isolated from local habitat and isolate designated as GP-35 produced maximum bacitracin production (14±0.72 IU ml-1). Bacitracin production of Bacillus licheniformis GP-35 was increased to 23±0.69 IU ml-1 after treatment with ultraviolet (UV) radiations. Similarly, treatment of vegetative cells of GP-35 with chemicals like N-methyl N’-nitro N-nitroso guanidine (MNNG) and Nitrous acid (HNO2) increased the bacitracin production to a level of 31±1.35 IU ml-1 and 27±0.89 IU ml-1respectively. Treatment of isolate GP-35 with combined effect of UV and chemical treatment yield significantly higher titers of bacitracin with maximum bacitracin production of 41.6±0.92 IU ml-1. Production of bacitracin was further enhanced (59.1±1.35 IU ml-1) by optimization of different parameters like phosphate sources, organic acids as well as temperature and pH. An increase of 4.22 fold in the production of bacitracin after mutagenesis and optimization of various parameters was achieved in comparison to wild type. Mutant strain was highly stable and produced consistent yield of bacitracin even after 15 generations. On the basis of kinetic variables, notably Yp/s (IU/g substrate), Yp/x (IU/g cells), Yx/s(g/g), Yp/s, mutant strain B. licheniformis UV-MN-HN-6 was found to be a hyperproducer of bacitracin.

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Topical Application of Bacitracin Ointment Is Associated with Decreased Risk of Mediastinitis after Median Sternotomy

Abstract: The use of topical antibacterials is associated with a decrease in the risk of mediastinitis after cardiac surgery.

Cited by 12 publications

References 32 publications

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

Gentamicin collagen sponges for the prevention of sternal wound infection: A meta-analysis of randomized controlled trials

Local antibiotics in dermatology

Systematic mutagenesis method for enhanced production of bacitracin by Bacillus licheniformis mutant strain UV-MN-HN-6

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