Topical Benzocaine-Induced Methemoglobinemia During Transesophageal Echocardiography in the Intensive Care Unit.

Taylor, Dennis; Miles, William S.; Schiffern, Lynn; Thomason, Michael; Larrazabal, Cynthia

doi:10.1097/00003246-200612002-00583

Cited by 1 publication

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“…Moreover, 20% is the maximum content approved in sprays with benzocaine. Despite this, researchers still found that the use of benzocaine spray in endoscopy, intubation, bronchoscopy, and similar invasive procedures may cause methemoglobinemia [ 4 , 5 , 6 ]. Besides, benzocaine has been used effectively as a general anesthetic for short-term sedation of fish during transport, spawning, and stocking operations in aquaculture of many fishery countries, such as America, Canada, Japan, etc.…”

Section: Introductionmentioning

confidence: 99%

Determination of Benzocaine in Pharmaceutical Formulations by Indirect SERRS Assay Combined with Azo Coupling

et al. 2022

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Coupled with an azo coupling reaction, a simple, rapid, sensitive, and effective surface-enhanced resonance Raman scattering (SERRS) detection method for benzocaine was developed. In our study, benzocaine which is used clinically as a local anesthetic was derived with p-aminothiophenol into a corresponding azo product within 5 min, resulting in a strong SERRS response with the simple addition of Ag NPs excited with a 532 nm laser. The linear correlation between SERRS intensity of dominant bands and logarithm of benzocaine concentration was investigated for quantitative determination. The method reached a limit of detection (LOD) down to 0.139 and 0.0788 μg/mL calculated with two peak intensity ratios (I1568/I2260 and I1331/I2260), which is comparable to most studies reported previously, and meanwhile had superiority in simplicity and rapidness. The quantitative measurements for pharmaceutical preparations with benzocaine were conducted without complex extraction and enrichment processes. It was indicated that the SERRS assay combined with azo derivatization reaction has implications for practical applications in more complicated systems involving biological samples, in which appropriate and simplified pretreatments were conducted to remove interfering components.

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Section: Introductionmentioning

confidence: 99%