Topical chlorhexidine, povidone-iodine and erythromycin in the repair of traumatic ulcers on the rat tongue: Clinical, histological and microbiological evaluation

Teixeira, Dieni Da Silveira; Figueiredo, Maria Antonia Zancanaro de; Cherubini, Karen; Garcia, Maria Cláudia Rosa; Oliveira, Sı́lvia Dias de; Salum, Fernanda Gonçalves

doi:10.1016/j.archoralbio.2018.01.001

Cited by 11 publications

(13 citation statements)

References 44 publications

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“…An ulcer was then produced on the ventral tongue of each rat at the midline, up to 3 mm from the apex. All lesions were performed by the same operator, using disposable punches of 5 mm in diameter (Bleymed Equipamentos Médicos, Curitiba, PR, Brazil) and penetrating 1 mm deep in the tissue, to standardize wound size (Teixeira et al, ; Figure ). Hemostasis was achieved by pressing sterile gauze on the surgical wound.…”

Section: Methodsmentioning

confidence: 99%

“…The CBD doses were selected according to the previous studies (Jamontt, Molleman, Pertwee, & Parsons, ; Malfait et al, ; Napimoga et al, ), and animals were weighed daily for dose adjustment. Half of the sample (10 animals of each group) were euthanized at 3 days and the remaining animals at 7 days of treatment, using a carbon dioxide chamber (Teixeira et al, ).…”

Section: Methodsmentioning

confidence: 99%

“…The presence of edema, hyperemia, and inflammatory infiltrate was determined. The field showing the most intense inflammatory response for each specimen was selected and then classified into four different scores (de Freitas Cuba, Braga Filho, Cherubini, Salum, & Figueiredo, ; Teixeira et al, ). 0.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies have investigated the development of an ideal healing agent, although there is still no widely accepted or gold standard treatment for the management of oral ulcers. Different strategies are often combined and involve the use of corticosteroids (Oliveira et al, ), antibiotics (Teixeira et al, ), laser therapy (Wagner et al, ), and natural compound formulations (Coelho et al, ; Lim et al, ). However, these alternatives may not have significant benefits or can even lead to unwanted side effects (Coelho et al, ; Oliveira et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation

Klein

Bortolli

Guimarães

et al. 2018

Phytotherapy Research

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The effects of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, were assessed on oral wound healing in an in vivo model. Standardized ulcers were induced in 60 Wistar rats using a 5-mm biopsy punch on the midline of the ventral tongue. Animals received intraperitoneal injections of CBD at doses of 0 (control), 5, and 10 mg/kg daily. Animals were weighed daily, and wound healing was clinically and histologically evaluated after 3 and 7 days of treatment. CBD treatment did not influence the wound area of ulcerative lesions at either observation time. Conversely, microscopic findings revealed that at Day 3 postwounding, CBD-treated lesions exhibited significantly lower inflammatory scores than those in the control group. However, this difference was not observed at Day 7. Collectively, these findings indicate that CBD exert an antiinflammatory effect in early phase of wound healing process although it was not sufficient promote clinical improvement of oral traumatic ulcerative lesions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation

Klein

Bortolli

Guimarães

et al. 2018

Phytotherapy Research

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“…Interventions to prevent such clinical episodes are necessary. Drugs such as corticosteroids, antibiotics, anaesthetics, anti‐inflammatories, antihistamines and antiseptics have been used topically and/or systemically to promote the healing process and decrease the painful symptoms of patients …”

Section: What Is Known and Objectivesmentioning

confidence: 99%

Doxycycline: An option in the treatment of ulcerated oral lesions?

et al. 2019

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What is known and objectives In addition to its antimicrobial effect, doxycycline has potent anti‐inflammatory activity. In view of these pharmacological characteristics, its use in the management of inflammatory, autoimmune and granulomatous diseases has been proposed. The objective of this study was to investigate, through a systematic literature review, the effect of doxycycline on pain and healing of ulcerated lesions of the mouth. Methods An electronic search was performed in accordance with PRISMA guidelines in PubMed, Cochrane Central Register, Web of Science, Bireme/LILACS and Scopus databases. Controlled, randomized clinical trials were selected. The concentration of doxycycline, frequency of application, pain relief and clinical remission of the lesions were analysed. Results and discussion According to the inclusion criteria, five articles were selected. In four of these studies, doxycycline was used in the treatment of aphthous stomatitis, and in one study, it was used in the treatment of herpes labialis. In all studies, the drug was used topically, both as a hydrogel and as a crushed tablet (along with a prosthetic adhesive). The groups treated with doxycycline showed faster healing of lesions and lower pain scores compared to placebo. What is new and conclusion The present study suggests that topical doxycycline has a positive effect on the treatment of recurrent aphthous ulceration and herpes labialis. Experimental animal studies and double‐blind randomized clinical trials should be performed on other oral lesions, such as traumatic ulcers and mucositis.

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Mg-MOF74 derivant with photothermal antibacterial activity and enhanced pro-healing effects for the treatment of traumatic oral ulcers

Liang,

Ning,

Lan

et al. 2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Topical chlorhexidine, povidone-iodine and erythromycin in the repair of traumatic ulcers on the rat tongue: Clinical, histological and microbiological evaluation

Cited by 11 publications

References 44 publications

Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation

Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation

Doxycycline: An option in the treatment of ulcerated oral lesions?

Mg-MOF74 derivant with photothermal antibacterial activity and enhanced pro-healing effects for the treatment of traumatic oral ulcers

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