Topical delivery of antifungal agents

Kaur, Indu Pal; Kakkar, Shilpa

doi:10.1517/17425247.2010.525230

Cited by 141 publications

(111 citation statements)

References 106 publications

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“…5 Various topical forms of TB marketed under the trademark Lamisil ® (Novartis Pharmaceuticals, East Hanover, NJ), such as cream, gel, spray solution, and film-forming solution (FFS; eg, Lamisil ® Once™; Novartis Pharmaceuticals), were approved for treating tinea pedis in many countries. 6 In vitro TB is the most active against dermatophytes, such as Trichophyton, Microsporum, and Epidermophyton spp., with minimum inhibitory concentrations (MICs) of 0.001-0.05 µg/mL. That of azole antifungal agents (eg, clotrimazole, miconazole, bifonazole, or oxiconazole), on the other hand, range from 0.1 to .10 µg/mL.…”

Section: Introductionmentioning

confidence: 99%

Development of terbinafine solid lipid nanoparticles as a topical delivery system

Chen

Liu²,

Liu³

et al. 2012

IJN

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Abstract:To resolve problems of long treatment durations and frequent administration of the antifungal agent terbinafine (TB), solid lipid nanoparticles (SLNs) with the ability to load lipophilic drugs and nanosize were developed. The SLNs were manufactured by a microemulsion technique in which glyceryl monostearate (GMS), glyceryl behenate (Compritol ® 888; Gattefossé), and glyceryl palmitostearate (Precirol ® ATO 5; Gattefossé) were used as the solid lipid phases, Tween ® and Cremophor ® series as the surfactants, and propylene glycol as the cosurfactant to construct ternary phase diagrams. The skin of nude mice was used as a barrier membrane, and penetration levels of TB of the designed formulations and a commercial product, Lamisil ® Once™ (Novartis Pharmaceuticals), in the stratum corneum (SC), viable epidermis, and dermis were measured; particle sizes were determined as an indicator of stability. The optimal SLN system contained a ,5% lipid phase and .50% water phase. The addition of ethanol or etchants had no significant effect on enhancing the amount of TB that penetrated the skin layers, but it was enhanced by increasing the percentage of the lipid phase. Furthermore, the combination of GMS

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Section: Introductionmentioning

confidence: 99%

Development of terbinafine solid lipid nanoparticles as a topical delivery system

Chen

Liu²,

Liu³

et al. 2012

IJN

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“…According to ternary diagram sertaconazole, loaded microemulsion [20][21][22] was selected comprising of different component ratio. The microemulsion was prepared with reference to the area in the ternary diagrams, the Sertaconazole nitrate-loaded microemulsion was selected having different oil and Smix ratio.…”

Section: Preparation Of Microemulsionsmentioning

confidence: 99%

“…Franz diffusion apparatus having an effective diffusion [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] area of 3.14 cm 2 receptor volume was 20 ml were employed for the permeation study. The optimized skin was placed at 25 o C for 30 minutes before conducting the experiment.…”

Section: Permeation Retention Studiesmentioning

confidence: 99%

Design Development and Evaluation of Topical Microemulsion

Muzaffar¹,

Singh²

2017

Int. Res. J. Pharm.

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A microemulsion based gel was designed for the topical and targeted delivery of sertaconazole nitrate for the treatment of su perficial fungal infection. The microemulsion region was obtained using a ternary diagram, different ratio of oil and Smix were used. The microemulsion of sertaconazole containing 2% (w/w) of sertaconazole, 6.67% (w/w) of oil phase (Eugenol+Oleic acid 1:1), 60.18% (w/w) of surfactant mixture 2:1 ratio (Tween-80 and Transcutol-P) and 33.15% (w/w) with distilled water. The prepared microemulsion gel and commercial cream of sertaconazole were evaluated for in-vitro and ex-vivo studies. The highest drug retention was achieved with Tween 80 and Transcutol P (T80TC45) when the optimized formulation was converted to a gel. The designed formulation MG2 was safe to be used over the skin as the PDI=0 when compared with commercial cream and MG1. The optimized formulation also posse's anti-inflammatory activity. The average zone of inhibition of MG2 was (23.19 ± 0.478) which was more than the commercial cream (15.34 ± 0.382) or MG1 (17.78 ± 0.715). Candida albicans which may be due to better permeation and retention effect of microemulsion gel 2. The MG2 was found to be stable after six month. The results obtained in this research from in vitro and in vivo data it can be concluded that the developed microemulsions have great potential for topical drug delivery in the treatment of inflammation and fungal infection.

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“…First, due to the critical and pharmacokinetically specific environment that exists in the eye, topical drug delivery is complicated by effective removal mechanisms, including the blink reflex, tear turnover, and limited drug contact time. 4,5 Second, the human cornea, which comprises epithelium, the substantia propria, and endothelium, restricts the ocular entry of drug molecules. 6,7 Amphotericin B has a high molecular mass (924.10 Da), so cannot easily penetrate the intact corneal epithelium.…”

Section: Introductionmentioning

confidence: 99%

Self-aggregated nanoparticles based on amphiphilic poly(lactic acid)-grafted-chitosan copolymer for ocular delivery of amphotericin B

Zhou¹,

Wang²,

Jian³

et al. 2013

IJN

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Topical delivery of antifungal agents

Abstract: A physicochemical and pharmacokinetic guided approach can help to tailor-make therapeutically effective systems for existing antifungal agents, thus doing away with the need for newer agents, which will save on time, money and manpower.

Cited by 141 publications

References 106 publications

Development of terbinafine solid lipid nanoparticles as a topical delivery system

Development of terbinafine solid lipid nanoparticles as a topical delivery system

Design Development and Evaluation of Topical Microemulsion

Self-aggregated nanoparticles based on amphiphilic poly(lactic acid)-grafted-chitosan copolymer for ocular delivery of amphotericin B

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