Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: A preclinical study

Oryan, Ahmad; Alemzadeh, Esmat; Tashkhourian, Javad; Ana, Sayedeh Fatemeh Nami

doi:10.1016/j.carbpol.2018.07.077

Cited by 76 publications

(35 citation statements)

References 53 publications

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“…Coupling of nanoparticles with other wound dressing materials promotes the removal of microbes from the site of wound which would otherwise cause interruption and delays the normal phases of healing. Topical application of chitosancapped AgNPs has been recently shown to accelerate the healing of a burn wound where it decreased the inflammatory reaction and consequently, reducing the length of repair phase [137]. In Katas et al [138], AgNPs was used as excellent healing wound dressings because of the acceleration of reepithelization and increased performance at clearing bacteria from infected wounds.…”

Section: Applications Of Metallic Nanoparticles In Wound Healingmentioning

confidence: 99%

Biomedical Applications of Green Synthesized-Metallic Nanoparticles: A Review

Lateef

Elegbede

Akinola

et al. 2019

PAJOLS

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Advances in the field of nanoscience and nanotechnology to modulate materials at nanoscale level has continued to have great impact on different disciplines of science and engineering as well as agriculture and medical fields. The surge in the utilization of benign and non-toxic biomolecules to engineer enhanced biocompatible nanomaterials has contributed to a large extent to the applications of nanomaterials in healthcare; an emerging sub-discipline termed nanomedicine. Among the several nanomaterials that have been produced, metallic nanoparticles occupy prime position owing to their optical, catalytic and biological characteristics. These nanoparticles, which are of different types existing singly as mono-metallic nanoparticles or in two or more metals as alloys have found extremely useful applications as antimicrobial, antioxidant, anticancer, antidiabetic, anticoagulant and thrombolytic agents amongst others. In this review, an attempt is made to project the different applications of green synthesized metallic nanoparticles in diverse areas of biomedicine, including the discussion of issues of toxicity and prospects of nanotechnology in biomedical field.

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Section: Applications Of Metallic Nanoparticles In Wound Healingmentioning

confidence: 99%

Biomedical Applications of Green Synthesized-Metallic Nanoparticles: A Review

Lateef

Elegbede

Akinola

et al. 2019

PAJOLS

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“…In addition, AgNPs inhibit the activities of proinflammatory cytokines interferon gamma and tumor necrosis factor alpha [41]. In an animal model, topical application of chitosan-capped AgNPs accelerated the healing of a burn wound healing by decreasing the inflammatory reaction, and subsequently, decreasing the duration of the repair phase [42]. A previous report has described the applications of biosynthesized AgNPs and AuNPs in wound healing [43].…”

Section: Wound Healing Agentsmentioning

confidence: 99%

“…Chitosan is an extensively investigated biomolecule for the synthesis of metallic nanoparticles. Previous studies have shown that chitosan can be used as a protecting or a stabilizing agent [16,42]. Moreover, chitosan has been used as a reducing agent in the synthesis of metallic nanoparticles.…”

Section: Chitosan As a Reducing And/or Stabilizing Agentmentioning

confidence: 99%

Biosynthesis and Potential Applications of Silver and Gold Nanoparticles and Their Chitosan-Based Nanocomposites in Nanomedicine

Katas

Moden

Lim

et al. 2018

Journal of Nanotechnology

102

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Biosynthesized or biogenic metallic nanoparticles, particularly silver and gold nanoparticles (AgNPs and AuNPs, respectively), have been increasingly used because of their advantages, including high stability and loading capacity; moreover, these nanoparticles are synthesized using a green and cost-effective method. Previous studies have investigated reducing and/or stabilizing agents from various biological sources, including plants, microorganisms, and marine-derived products, using either a one-pot or a multistep process at different conditions. In addition, extensive studies have been performed to determine the biological or pharmacological effects of these nanoparticles, such as antimicrobial, antitumor, anti-inflammatory, and antioxidant effects. In the recent years, chitosan, a natural cationic polysaccharide, has been increasingly investigated as a reducing and/or stabilizing agent in the synthesis of biogenic metallic nanoparticles with potential applications in nanomedicine. Here, we have reviewed the mechanism of biosynthesis and potential applications of AgNPs and AuNPs and their chitosan-mediated nanocomposites in nanomedicine.

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“…To avoid opsonization and phagocytic clearance, NPs can be modified by decoration with a variety of molecules to change the properties of the particle surface, postponing opsonization by the immune system. In addition to the use of peptides as capping agent, the most common molecules used for this purpose are polyethylene glycol (PEG), chitosan, citrate, polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) [41,42,43]. In addition to this function, the use of capping agents is important in the delivery of hydrophobic coating NPs (which tend to clump together and are readily captured by phagocytes from the mononuclear system).…”

Section: Introductionmentioning

confidence: 99%

Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery

et al. 2019

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Antimicrobial peptides (AMPs) have been described as excellent candidates to overcome antibiotic resistance. Frequently, AMPs exhibit a wide therapeutic window, with low cytotoxicity and broad-spectrum antimicrobial activity against a variety of pathogens. In addition, some AMPs are also able to modulate the immune response, decreasing potential harmful effects such as sepsis. Despite these benefits, only a few formulations have successfully reached clinics. A common flaw in the druggability of AMPs is their poor pharmacokinetics, common to several peptide drugs, as they may be degraded by a myriad of proteases inside the organism. The combination of AMPs with carrier nanoparticles to improve delivery may enhance their half-life, decreasing the dosage and thus, reducing production costs and eventual toxicity. Here, we present the most recent advances in lipid and metal nanodevices for AMP delivery, with a special focus on metal nanoparticles and liposome formulations.

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Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: A preclinical study

Cited by 76 publications

References 53 publications

Biomedical Applications of Green Synthesized-Metallic Nanoparticles: A Review

Biomedical Applications of Green Synthesized-Metallic Nanoparticles: A Review

Biosynthesis and Potential Applications of Silver and Gold Nanoparticles and Their Chitosan-Based Nanocomposites in Nanomedicine

Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery

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