Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review

Kauth, Marion; Trusova, O. V.

doi:10.1007/s13555-021-00676-9

Cited by 23 publications

(12 citation statements)

References 56 publications

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“…It was initially described as a cell membrane protector with outstanding water-binding and stabilizing properties that could reduce transepidermal water loss, chemical and physical penetration, and subsequent inflammation. 20 At concentrations of 2% and higher, ectoine improves dryness and impaired skin barrier induced by UVA irradiation than with UV filters. Interestingly, the active association also preserved both in vitro Langerhans cells functionality and in vivo trans-UCA transformation to cis-UCA (known to be immunosuppressive 25 ), suggesting that it could protect skin from UV-induced immunosuppression.…”

Section: Discussionmentioning

confidence: 97%

“…In addition, ectoine, a cyclic amino acid produced by extremophile microorganisms, can prevent many UV/light consequences (Langerhans cells migration, 18 pro‐inflammatory cytokines release, 19 DNA damages, 17 sunburn cell formation 18 ). Moreover, ectoine was initially described as a cell membrane protector reducing transepidermal water loss, chemical and physical penetration, and subsequent inflammation, and effective in atopic skin and prevention of skin aging 20 . The present study aimed to characterize the photoprotection properties of an association of ectoine and mannitol and to investigate its additional photoprotection against UVA and UVB effect in humans in combination with UV filters based on the assessment of specific UV‐induced biomarkers (squalene, trans‐UCA, and catalase activity).…”

Section: Introductionmentioning

confidence: 99%

“…*p < 0.05, and **p < 0.01; ns, not significant. it has been described as being effective for treatment of atopic skin and prevention of skin aging 20. Interestingly, other studies have shown that ectoine prevents UV-induced migration of Langerhans cells 18 and pro-inflammatory cytokines release,19 protects DNA against visible light, 17 mtDNA against UV rays, 23 and prevents sunburn cell formation 18.…”

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confidence: 99%

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Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters

Fontbonne¹,

Témé²,

Abric³

et al. 2023

J of Cosmetic Dermatology

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BackgroundChronic exposure to ultraviolet (UV) irradiation causes immunosuppression, photoaging, and carcinogenesis by induction of a cascade of skin damages. Sunscreens currently on the market are not absorbing UV rays uniformly throughout the full UV range, high sun protection factor (SPF) sunscreens absorb most of UVB rays but are less effective in absorbing the UVA part of the spectrum. In the context, one approach could consist of preserving the skin natural resources and mechanisms, which is the foundation of the ecobiological approach, by combing UV filters and antioxidants to enhance their photoprotective effect.MethodsFirst, the photoprotection properties of ectoine and mannitol association were characterized by the quantification of glutathione, reactive oxygen species, and double‐stranded DNA breaks and by the epidermal Langerhans cells functionality. Second, the protection of squalene oxidation, catalase activity, and trans‐urocanic acid (UCA) by the ectoine and mannitol association combined or not with SPF30 UV filters was assessed in vivo via non‐invasive skin samplings in 10 subjects on irradiated areas.ResultsUsing in vitro irradiated skin cell models, we demonstrated that this association significantly preserved intracellular glutathione levels, reduced DNA strand breaks induced by oxidative stress, and maintained Langerhans cell functionality. In vivo this association combined with UV filters presented significantly higher protection of three natural defense systems altered by UV compared to UV filters alone: squalene oxidation, catalase activity, and preservation of trans‐UCA.ConclusionThis study demonstrates the ecobiological potential of combining UV filters with biological protection to increase skin photoprotection provided by specific active ingredients with antioxidative and immunosuppressive properties.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters

Fontbonne¹,

Témé²,

Abric³

et al. 2023

J of Cosmetic Dermatology

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“…Most of halophilic microorganisms accumulate organic compatible solutes to maintain the balance of osmotic pressure of the intracellular and the external environment ( Gunde-Cimerman et al, 2018 ). Among them, ectoine was initially found in Ectothiorhodospira halochloris ( Galinski et al, 1985 ) and is widely used in the fields of food, cosmetics, and medicine ( Liu et al, 2021 ; Kauth and Trusova, 2022 ; Zhang H. et al, 2022 ). Recent studies have shown that there was also the native synthesis of ectoine in some microalgae ( Fenizia et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Improved salt tolerance of Synechococcus elongatus PCC 7942 by heterologous synthesis of compatible solute ectoine

Dong

Sun²,

Zhang³

et al. 2023

Front. Microbiol.

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Salt stress is one of the essential abiotic stresses for the survival of cyanobacteria. However, the realization of large-scale cultivation of cyanobacteria is inseparable from the utilization of abundant seawater resources. Therefore, research on the regulatory mechanism, as well as the improvement of salt tolerance of cyanobacteria is fundamental. Ectoine, a compatible solute which was found in halophilic microorganisms, has potentiality to confer salt tolerance. Here in this article, the salt tolerance of Synechococcus elongatus PCC 7942 (Syn7942) was significantly improved via expressing the ectoine biosynthetic pathway, reaching an increased final OD750 by 20% under 300 mM NaCl and 80% under 400 mM NaCl than that of wild-type (WT), respectively. Encouragingly, the engineered strain could even survive under 500 mM NaCl which was lethal to WT. In addition, by introducing the ectoine synthetic pathway into the sucrose-deficient strain, the salt tolerance of the obtained strain Syn7942/Δsps-ect was restored to the level of WT under 300 mM NaCl stress, demonstrating that ectoine could substitute for sucrose to combat against salt stress in Syn7942. In order to study the difference in the regulation of mechanism on the salt adaptation process after replacing sucrose with ectoine, transcriptomic analysis was performed for Syn7942/Δsps-ect and WT. The differentially expressed gene analysis successfully identified 19 up-regulated genes and 39 down-regulated genes in Syn7942/Δsps-ect compared with WT under salt stress condition. The results also showed that the global regulation of Syn7942/Δsps-ect and WT had certain differences in the process of salt adaptation, in which Syn7942/Δsps-ect reduced the demand for the intensity of sulfur metabolism in this process. This study provides a valuable reference for further salt tolerance engineering in cyanobacteria.

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“…The skin is the largest organ of the human body and is a complex human protective barrier, protecting the human body from external invasion and moisture loss through the physical and chemical barriers ( 8 ). Skin inflammation is attributed to the derangement of the epidermal barrier function ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Study on the mechanism of cadmium chloride pollution accelerating skin tissue metabolism disorder, aging and inhibiting hair regeneration

Du¹,

Dong²,

Wang³

et al. 2022

Front. Public Health

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Drinking water contaminated by Cd2+ is one of the main pathways for Cd to enter the body. The skin barrier is destroyed when the skin is contaminated by environmental Cd2+, however, the detailed mechanism by which Cd2+ induces skin metabolic disorder, and senescence and affects hair regeneration is not completely understood. In this study, 18 C57BL/6 mice were randomly divided into a Control group, a Low-dose group, and a High-dose group with 6 mice in each group, and intragastrically administered with different concentrations of cadmium chloride once a day, respectively. After 1 month of intervention, the skin tissues on the back of mice were collected for non-targeted metabolomics analysis, and the related proteins were detected by immunofluorescence assay. Non-targeted metabolomics analysis result showed that compared with the Control group, there were 29 different metabolites, mainly including lysophospholipids, fatty acids, and bile acids, in the Low-dose group, and 39 differential metabolites in the High-dose group, in addition to the above compounds, there were more amino acid compounds, and most of the metabolites had a reduced response after administration. Immunofluorescence assay result showed that the higher the concentration of cadmium chloride led to the more obvious the proliferation inhibition and apoptosis promotion effects of skin cells, and the more significant damage to hair follicle stem cells. Thus, our findings demonstrate that cadmium chloride pollution can accelerate skin metabolism disorder, and aging and impair hair regeneration.

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Topical Ectoine Application in Children and Adults to Treat Inflammatory Diseases Associated with an Impaired Skin Barrier: A Systematic Review

Cited by 23 publications

References 56 publications

Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters

Positive and ecobiological contribution in skin photoprotection of ectoine and mannitol combined in vivo with UV filters

Improved salt tolerance of Synechococcus elongatus PCC 7942 by heterologous synthesis of compatible solute ectoine

Study on the mechanism of cadmium chloride pollution accelerating skin tissue metabolism disorder, aging and inhibiting hair regeneration

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