Topical electrospun patches loaded with oil for effective gamma linoleic acid transport and skin hydration towards atopic dermatitis skincare

Sroczyk, Ewa A.; Berniak, Krzysztof; Jaszczur, Marek; Stachewicz, Urszula

doi:10.1016/j.cej.2021.132256

Cited by 25 publications

(27 citation statements)

References 66 publications

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“…Applying the oil to the patches, both from pure PHBV fibers and EPO blends, clearly indicates that these materials increase skin hydration. Previous studies carried out with the use of electrospun fibers PCL, 24 PVB, 23,75 and PI 91 confirm the effectiveness of the use of patches with oil to moisturize the skin. This type of dressing can be crucial in preventing dry skin, which is one of the problems faced by people suffering from atopic dermatitis.…”

Section: Skin Test Of Electrospun Patchesmentioning

confidence: 62%

Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort

2022

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Section: Skin Test Of Electrospun Patchesmentioning

confidence: 62%

Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort

2022

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“…As previously described, fatty acids induce a positive effect towards the skin cells by their protective and anti-inflammatory actions [ 30 ]. In the former studies, palmitoleic acid, the omega-7 monounsaturated acid that was proven to regulate the cytokine and type IV collagen levels [ 31 ], linoleic acid, the omega-6 polyunsaturated fatty acid that was found to be an efficient emollient and thickening agent [ 32 ], and palmitic acid, one of the most prevalent saturated oils of vegetable origin, were described as ingredients in hair- and skin-care products for their moisturizing and texturizing properties [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Assessment of Cucurbita spp. Peel Extracts as Potential Sources of Active Substances for Skin Care and Dermatology

et al. 2022

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By-products of cultivated plants are one of the major environmental concerns worldwide. Due to the high concentration of bioactive chemicals, such waste may be considered hazardous due to the interference with the plant growth, deterioration of the drinking water quality or toxic effects on sensitive marine organisms. Moreover, plant-derived by-products, with proper handling, may represent a low-cost source of bioactive compounds potentially important for pharmaceutical and cosmetics industries. The aim of the study was to evaluate the phytochemical composition, antioxidant activity, the influence of tyrosinase activity, in vitro sun protecting factor and cytotoxicity of 15 extracts from peels of five cultivars of Cucurbita maxima and C. moschata. The extracts were prepared using “green solvents” (water, 50% propylene glycol, and 20% ethanol) and ultrasound-assisted extraction. The performed analysis showed that the peel extracts from various cultivars differ significantly in respect to the phytochemical content and activity. The type of solvent also had a significant impact on the extract’s composition and bioactivity. Aqueous peel extracts contained the highest amounts of flavonoids, showed the greatest antioxidant potential and the most significant in vitro SPF values. In vitro studies showed that the analyzed peel extracts are not cytotoxic for human keratinocytes up to the concentration of 1000 µg/mL and thus might be considered as non-irritant for the skin. The study confirms the potential application of peel extracts from Cucurbita spp. cultivars in cosmetic products.

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“…There are a few examples of electrospun fibers used as patches for skin care, except for wound healing dressings. These fibers were loaded with oils blackcurrant seed (Sroczyk et al, 2021), hemp seed (Metwally et al, 2020), borage, black cumin seed, and evening primrose (Krysiak, Kaniuk, et al, 2020; Krysiak, Knapczyk‐Korcak, et al, 2020) by simple absorption and used as a moisturizing bandage for dry skin. A nanosized polyamide 6 (PA6) fiber‐based dressing was compared with polystyrene (PS) microfibers to verify borage oil delivery to the dry skin.…”

Section: Electrospinningmentioning

confidence: 99%

“…(h) Representative image of the experimental arrangements of patches on volunteers. Reproduced with permission from Sroczyk et al (2021). Heat transmission rates through PHBV, PHBV + 5%EPO, and PHBV + 10%EPO electrospun fibers and samples with an additional EPO: (i) just after patch and oil application, (j) after 3 h of wearing the patch.…”

Section: Examples Of Electrospun Skin Patchesmentioning

confidence: 99%

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

Krysiak

Stachewicz

2022

WIREs Nanomed Nanobiotechnol

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The skin is a complex layer system and the most important barrier between the environment and the organism. In this review, we describe some widespread skin problems, with a focus on eczema, which are affecting more and more people all over the world. Most of treatment methods for atopic dermatitis (AD) are focused on increasing skin moisture and protecting from bacterial infection and external irritation. Topical and transdermal treatments have specific requirements for drug delivery. Breathability, flexibility, good mechanical properties, biocompatibility, and efficacy are important for the patches used for skin. Up to today, electrospun fibers are mostly used for wound dressing.Their properties, however, meet the requirements for skin patches for the treatment of AD. Active agents can be incorporated into fibers by blending, coaxial or side-by-side electrospinning, and also by physical absorption postprocessing. Drug release from the electrospun membranes is affected by drug and polymer properties and the technique used to combine them into the patch. We describe in detail the in vitro release mechanisms, parameters affecting the drug transport, and their kinetics, including theoretical approaches. In addition, we present the current research on skin patch design. This review summarizes the current extensive know-how on electrospun fibers as skin drug delivery systems, while underlining the advantages in their prospective use as patches for atopic dermatitis.

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Topical electrospun patches loaded with oil for effective gamma linoleic acid transport and skin hydration towards atopic dermatitis skincare

Cited by 25 publications

References 66 publications

Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort

Enhanced mechanical performance and wettability of PHBV fiber blends with evening primrose oil for skin patches improving hydration and comfort

Assessment of Cucurbita spp. Peel Extracts as Potential Sources of Active Substances for Skin Care and Dermatology

Electrospun fibers as carriers for topical drug delivery and release in skin bandages and patches for atopic dermatitis treatment

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