Topical essential fatty acid oil on wounds: Local and systemic effects

Evidence-Based Complementary and Alternative Medicine

et al. 2020

Babassu (Attalea speciosa Mart. ex Spreng., Arecaceae) is a palm tree endemic to Brazil and found mainly in the borders of Amazon forest, where the harvesting of its fruits is an important source of income for more than 300,000 people. Among the communities of coconut breakers women, babassu oil is used in culinary, as fuel, and mostly as medicinal oil for the treatment of skin wounds and inflammation. This study aimed to evaluate in vitro and in vivo the wound healing effects of babassu oil. In vitro, babassu oil increased the migration of L929 fibroblasts, inhibited the production of nitric oxide by LPS-stimulated peritoneal macrophages, and increased the levels of INF-γ and IL-6 cytokines production. In vivo, babassu oil accelerated the healing process in a full-thickness splinted wound model, by an increase in the fibroblasts number, blood vessels, and collagen deposition in the wounds. The babassu oil also increased the recruitment of inflammatory cells into the wound site and showed an anti-inflammatory effect in a chronic ear edema model, reducing ear thickness, epidermal hyperplasia, and myeloperoxidase activity. Thus, these data corroborate the use of babassu oil in folk medicine as a remedy to treat skin wounds.

Section: Resultsmentioning

confidence: 99%

In Vitro and In Vivo Wound Healing and Anti‐Inflammatory Activities of Babassu Oil (Attalea speciosa Mart. Ex Spreng., Arecaceae)

Evidence-Based Complementary and Alternative Medicine

et al. 2020

“…A capacidade dos AGE que compõem o OG para promover o processo cicatricial em feridas tem sido pesquisada desde 1929. Atualmente, o OG é um dos produtos mais utilizados na pratica clínica para o tratamento e prevenção de feridas, visto que o óleo é rico em AGE e foi aprovado pela Agência Nacional de Vigilância Sanitária (Anvisa) como curativo, no entanto, poucos estudos discutem sua capacidade antibacteriana (Mota et al, 2015;(Lania, et al, 2019;Saturno, et al, 2017).…”

Section: Discussionunclassified

“…Os ácidos graxos essenciais (AGE) são produtos muito utilizados na prática clínica para o tratamento de feridas, tais como úlceras de pressão, neuropatias venosas e arteriais, queimaduras, deiscências cirúrgicas, entre outras, por apresentarem baixo custo, fácil acesso e ser um agente cicatrizante (Lania, et al, 2019;Tran, et al, 2018).…”

Section: Introductionunclassified

“…Entre os AGE destaca-se o óleo da semente de girassol (OG) (Helianthus annuus), considerado um óleo nobre utilizado na alimentação humana e em hospitais brasileiros com inúmeras apresentações comerciais para a prevenção e tratamento de feridas, por ter lipídios de composição semelhante ao estrato córneo (Lania, et al, 2019;Saturno, et al, 2017).…”

Section: Introductionunclassified

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Avaliação da atividade antibacteriana do óleo de girassol: Respaldo para a enfermagem

Zilly

et al. 2021

RSD

Esta pesquisa objetivou avaliar a atividade antibacteriana do óleo de girassol. Trata-se de uma pesquisa experimental, desenvolvida em 2020. Para a avaliação da atividade antimicrobiana do óleo de girassol, foi utilizado o método disco de difusão em meio sólido e cepas bacterianas de Staphylococcus aureus, Enterococcus faecalis e klebsiela pneumoniae da American Type Culture Collection. O halo de inibição de crescimento bacteriano formado pelo óleo de girassol sobre a bactérias Staphylococcus aureus ATCC 25923 foi de 9 mm, para a Enterococcus faecalis ATCC 29212 foi de 11 mm e para a Klebsiela pneumoniae ATCC 13883 foi de 12 mm, conferindo atividade de inibição bacteriana. O estudo aponta que o óleo de girassol é uma matéria orgânica promissora, respaldando cientificamente seu uso pela equipe de enfermagem na assistência integral ao ser humano, como forma de prevenir infecções e recuperar a integridade cutânea.

“…The addition of RPLO to human fibroblast cultures increased the cell migration rate compared to the control treatment. An increased fibroblast migration rate was also observed after supplementation of the medium with a mixture of vegetable oils [ 50 ]. In addition to the positive effects on the migration rate of fibroblasts, Guidoni et al [ 51 ] observed that a mixture of vegetable oils promoted an inflammatory response controlled by the modulation of the levels of pro-inflammatory mediators and cytokines (TNF-α and IL-6).…”

Section: Discussionmentioning

confidence: 99%

Rhynchophorus palmarum (Linnaeus, 1758) (Coleoptera: Curculionidae): Guarani-Kaiowá indigenous knowledge and pharmacological activities

et al. 2021

Zootherapy is a traditional secular practice among the Guarani-Kaiowá indigenous ethnic group living in Mato Grosso do Sul, Brazil. My people use the oil extracted from larvae of the snout beetle Rhynchophorus palmarum (Linnaeus, 1758) to treat and heal skin wounds and respiratory diseases. Based on this ethnopharmacological knowledge, the chemical composition and antioxidant, antimicrobial, and healing properties of R. palmarum larvae oil (RPLO) were investigated, as well as possible toxic effects, through in vitro and in vivo assays. The chemical composition of the RPLO was determined using gas chromatography coupled with mass spectrometry. The antioxidant activity of RPLO was investigated through the direct 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, and the antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria that are pathogenic to humans. The healing properties of RPLO were investigated by performing a cell migration assay using human lung fibroblasts (MRC-5), and the toxicity was analyzed, in vivo, using a Caenorhabditis elegans model and MRC-5 cells, in vitro. RPLO contains 52.2% saturated fatty acids and 47.4% unsaturated fatty acids, with palmitic acid (42.7%) and oleic acid (40%) representing its major components, respectively. RPLO possesses direct antioxidant activity, with a half-maximal inhibitory concentration (IC50) of 46.15 mg.ml-1. The antimicrobial activity of RPLO was not observed at a concentration of 1% (v/v). RPLO did not alter the viability of MRC-5 cells and did not exert toxic effects on C. elegans. Furthermore, MRC-5 cells incubated with 0.5% RPLO showed a higher rate of cell migration than that of the control group, supporting its healing properties. Taken together, RPLO possesses direct antioxidant activity and the potential to aid in the healing process and is not toxic toward in vitro and in vivo models, corroborating the safe use of the oil in traditional Guarani-Kaiowá medicine.