Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment

Dimitrovska, Ivana; Olumceva, Tanja; Markova, Elena; Kostoska, Monika; Taneska, Lea; Petrushevska, Marija; Makrievski, Vasil; Todorov, Jovica; Shalabalija, Dushko; Mihailova, Ljubica; Dimovski, Riste Popeski; Dodov, Marija Glavaš; Crcarevska, Maja Simonoska

doi:10.1007/s10570-020-03283-7

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…Fourier transform infrared spectroscopy‐attenuated total reflectance (FTIR‐ATR) analysis of loaded GG‐based structures (Figure 2c ) revealed spectral peaks characteristic of antibiotics and polymer, with no alterations in the characteristic peaks or in the appearance of new functional groups. Specifically, the infrared (IR) spectrum of loaded GG‐based structures showed small peaks in the range of 1700–1600 cm −1 related to the C=O stretching of amide carbonyl group of VAN 45 and CLD, 46 , 47 in addition to the characteristic peaks of GG: at around 3370 cm −1 attributed to O—H stretching of hydroxyl group; at 2914 cm −1 due to C—H stretching of alkyl group; at 1605 cm −1 related to the C=O stretching of carboxylate group; at 1405 cm −1 of methyl C—H bending; and at 1040 cm −1 attributed to the C—O stretching of alkyl ether. 48 , 49 , 50 …”

Section: Resultsmentioning

confidence: 99%

“…Polycarbonate membranes, 0.2 μm pore size (Merck KGaA, Germany) were used for MRSA growth and further wound infection, as previously 46 . First, membranes were cut in 5‐mm diameter discs and sterilized on both sides by UV light for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…Polycarbonate membranes, 0.2 μm pore size (Merck KGaA, Germany) were used for MRSA growth and further wound infection, as previously. 46 First, membranes were cut in 5‐mm diameter discs and sterilized on both sides by UV light for 30 min. Membranes were then placed on MSA and inoculated with 10 2 CFU of MRSA, previously diluted from a 10 8 bacterial suspension prepared as described for checkerboard assay, and incubated overnight at 37°C.…”

Section: Methodsmentioning

confidence: 99%

“…Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR) analysis of loaded GG-based structures (Figure 2c) revealed spectral peaks characteristic of antibiotics and polymer, with no alterations in the characteristic peaks or in the appearance of new functional groups. Specifically, the infrared (IR) spectrum of loaded GG-based structures showed small peaks in the range of 1700-1600 cm À1 related to the C O stretching of amide carbonyl group of VAN 45 and CLD, 46,47 [48][49][50] The release profile of VAN and CLD from GG-based spongy-like hydrogels was characterized by a burst release within the first 8 h of incubation, followed by a sustained release (Figure 2d). Considering the maximum experimental mass per loaded GG-based spongy-like hydrogel, respectively 32.6 and 42.3 μg for VAN and CLD, the cumulative release profile was identical for both antibiotics.…”

Section: Physicochemical Properties Of Loaded Ggbased Formulationsmentioning

confidence: 99%

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Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

Mendes

Fraga

Peixoto

et al. 2023

Bioengineering & Transla Med

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Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, antibiotics are often associated with adverse reactions. Hence, improved antibiotic therapies are required for safer and effective DFI management. On this regard, drug delivery systems (DDSs) constitute a promising strategy. We propose a gellan gum (GG)‐based spongy‐like hydrogel as a topical and controlled DDS of vancomycin and clindamycin, for an improved dual antibiotic therapy against methicillin‐resistant Staphylococcus aureus (MRSA) in DFI. The developed DDS presents suitable features for topical application, while promoting the controlled release of both antibiotics, resulting in a significant reduction of in vitro antibiotic‐associated cytotoxicity without compromising antibacterial activity. The therapeutic potential of this DDS was further corroborated in vivo, in a diabetic mouse model of MRSA‐infected wounds. A single DDS administration allowed a significant bacterial burden reduction in a short period of time, without exacerbating host inflammatory response. Taken together, these results suggest that the proposed DDS represents a promising strategy for the topical treatment of DFI, potentially overcoming limitations associated with systemic antibiotic administration and minimizing the frequency of administration.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Physicochemical Properties Of Loaded Ggbased Formulationsmentioning

confidence: 99%

See 2 more Smart Citations

Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

Mendes

Fraga

Peixoto

et al. 2023

Bioengineering & Transla Med

View full text Add to dashboard Cite

show abstract

“…There are many polymers like carbopol 934 (Said dos Santos et al., 2020 ; Batool et al., 2021 ), chitosan (Yenilmez et al., 2015 ; Dimitrovska et al., 2020 ; El Menshawe et al., 2020 ; Rabia et al., 2020 ), poloxamer (Chung et al., 2020 ; Cristiano et al., 2020 ) used for the formulation of topical gel. Among them, chitosan is a natural polymer used as a gelling agent for topical delivery.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

Alshehri

Imam

2021

Drug Delivery

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Composite polymeric microsponge‐based long‐acting gel formulation for topical delivery of mupirocin

Ramesh,

Hussain,

Roy

et al. 2023

J of Applied Polymer Sci

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Topical delivery of medicaments in a controlled manner is still a promising area of research. Drug‐containing dammar gum‐ethyl cellulose composite microsponge loaded gel formulation (D‐MSPG) was developed for controlled topical delivery of mupirocin. The drug‐loaded microsponges (D‐MSPs) were formulated by the quasi‐emulsion solvent diffusion method and were evaluated for morphology, particle size distribution, entrapment efficiency, thermal properties, and crystallinity. The optimized D‐MSPs (entrapment efficiency 91.5 ± 4.0% and particle size of 55.15 ± 2.9 μm) were dispersed in carbopol 934 gel (D‐MSPG). The final product was characterized for pH, viscosity, texture, spreadability, consistency, syneresis, in vitro drug release, and ex vivo skin penetration study. A comparative study with marketed formulation was performed. For optimized gel formulation (G4), drug content was 104.19 ± 1.68%, and drug release was 84.19% after 24 h. The pH of the optimized gel was observed to be 6.05 ± 0.04. Viscosity of the optimized gel formulation was found to be 1212.15 ± 434.85 mPa‐s at 50 s−1. The steady‐state flux (J) in ex vivo skin permeation was observed to be 53.96 μg cm−2 h−1 and the permeability coefficient was 2.69 cm/h for the optimized gel formulation. According to the findings, the D‐MSPG‐based formulation strategy can act well to prolong the topical delivery of mupirocin or similar drug molecules.

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Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment

Cited by 11 publications

References 30 publications

Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

Gellan gum spongy‐like hydrogel‐based dual antibiotic therapy for infected diabetic wounds

Formulation and evaluation of butenafine loaded PLGA-nanoparticulate laden chitosan nano gel

Composite polymeric microsponge‐based long‐acting gel formulation for topical delivery of mupirocin

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