Topical glucocorticosteroids in rhinitis: clinical aspects

Mygind, Niels; Andersson, Morgan

doi:10.1080/00016480600672550

Cited by 40 publications

(23 citation statements)

References 71 publications

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“…Since all applied substances apparently induce different effects on (aspects of) brain functioning, we have to pay some attention to the mechanisms involved in brain delivery of substances via the intranasal route and to the specificity of targeting the brain along the available routes of access. For the present purpose, a short survey will suffice since numerous reviews have been considering specific aspects of IN-administration over the last few years (Banks, 2006;Bos et al, 2012;Carnes and Robinson, 2008;Charlton et al, 2008;Dale et al, 2002;Dhuria et al, 2009aDhuria et al, , 2010Domes et al, 2010;Graff and Pollack, 2005;Grassin-Delyle et al, 2012;Guindon et al, 2007;Illum, 2003Illum, , 2004Jogani et al, 2008;Liu et al, 2012;Merkus and van den Berg, 2007;Meyer-Lindenberg, 2008;Mygind and Andersson, 2006;Pathan et al, 2009;Strachan, 2005;Striepens et al, 2011;Thorne et al, 1995;Van Ijzendoorn and Bakermans-Kranenburg, 2012;Viero et al, 2010).…”

mentioning

confidence: 99%

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Veening

Olivier

2013

Neuroscience & Biobehavioral Reviews

154

128

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The intranasal (IN-) administration of substances is attracting attention from scientists as well as pharmaceutical companies. The effects are surprisingly fast and specific. The present review explores our current knowledge about the routes of access to the cranial cavity. 'Direct-access-pathways' from the nasal cavity have been described but many additional experiments are needed to answer a variety of open questions regarding anatomy and physiology. Among the IN-applied substances oxytocin (OT) has an extensive history. Originally applied in women for its physiological effects related to lactation and parturition, over the last decade most studies focused on their behavioral 'prosocial' effects: from social relations and 'trust' to treatment of 'autism'. Only very recently in a microdialysis study in rats and mice, the 'direct-nose-brain-pathways' of IN-OT have been investigated directly, implying that we are strongly dependent on results obtained from other IN-applied substances. Especially the possibility that IN-OT activates the 'intrinsic' OT-system in the hypothalamus as well needs further clarification. We conclude that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects.

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mentioning

confidence: 99%

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Veening

Olivier

2013

Neuroscience & Biobehavioral Reviews

154

128

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“…In clinical rhinology, GC treatment is considered the first and limited efficient treatment of patients with CRSwNP. GCs were reported to be highly effective at alleviating nasal symptoms and nasal airflow, improving life quality and shrinking nasal polyps 32 . Dexamethasone also reduced the transcription of EMT-related genes such as those for vimentin and fibronectin in hepatocytes 18 and blocked TGF-β1-induced EMT and cell migration in lung epithelial cells 33 .…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoids ameliorate TGF-β1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways

Yang

Lee

Shin

et al. 2017

Sci Rep

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with tissue remodeling. Epithelial-to-mesenchymal transition (EMT), a process of tissue remodeling, can be a therapeutic target of CRSwNP. Glucocorticoids are a type of steroid hormone that is used primarily in medical therapy for patients with CRSwNP; however, their effects on EMT in the airway epithelium remain unknown. To investigate the effects of dexamethasone and fluticasone propionate, a class of glucocorticoids, on transforming growth factor-β1 (TGF-β1) -induced EMT, we used A549 cells, human primary nasal epithelial cells (hPNECs) and ex vivo organ culture of the inferior turbinate. TGF-β1 induced changes in cell morphology, suppressed the expression of E-cadherin and enhanced the expression of a-smooth muscle actin, vimentin and fibronectin in A549 cells. However, glucocorticoids inhibited EMT, migration and invasion enhancement by TGF-β1. We found that the induction of phosphorylated ERK, p38 and the activity of Snail and Slug transcription factors by TGF-β1 were suppressed by glucocorticoids. Glucocorticoids also had a similar effect in hPNECs and ex vivo organ cultures of the inferior turbinate. These findings suggest that glucocorticoids might be a useful therapy for preventing tissue remodeling by blocking the EMT initiated by TGF-β1-induced MAPK and Snail/Slug signaling pathways in CRSwNP.

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“…43 They are highly effective in disease states such as AR that are characterized by eosinophil-dominated inflammation. 44 INSs impede the influx of eosinophils, basophils, and mononuclear cells, and their promoting effects on eosinophil apoptosis may be an important factor in the resolution of inflammatory processes. 42,45 In allergic subjects, INSs have been shown to reduce the number of mast cells and eosinophils in the nasal epithelium and to significantly decrease the number of eosinophils in the lamina propria.…”

Section: Inss: Effects On the Biphasic Allergic Response And Cellularmentioning

confidence: 99%

Targeting congestion in allergic rhinitis: The importance of intranasal corticosteroids

Marple¹

2008

allergy asthma proc

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The cardinal nasal symptoms of allergic rhinitis (AR) are sustained by an underlying inflammatory process. Congestion is one of the most prominent and distressing symptoms for patients and is strongly associated with a broadly deteriorated quality of life and significant losses in productivity. The purpose of this study was to explore the role of intranasal corticosteroids (INSs) in down-regulating the inflammatory response to allergen and their clinical efficacy on AR symptoms, particularly congestion. AR is characterized by an influx of inflammatory cells and mediators into the nasal mucosa after antigen exposure. The response is biphasic, encompassing an early and a late phase. Antigen exposure has a priming effect, decreasing the threshold for subsequent allergic reaction on rechallenge and increasing the responsiveness of the nasal mucosa. INSs are a mainstay of therapy for AR and the most effective intervention for nasal congestion and other nasal symptoms, with established superiority to antihistamines, decongestants, and leukotriene antagonists. In addition to symptom relief, INSs suppress numerous stages of the inflammatory cascade, inhibiting the influx of inflammatory cells and mediators. Topical nasal corticosteroids have a low incidence of local adverse effects, negligible systemic absorption, and excellent safety. Congestion is one of the most bothersome symptoms of AR. INS therapy improves AR symptoms, with particular efficacy in relieving congestion, by attenuating nasal hyperresponsiveness. Pretreatment with INSs has been shown to relieve early and late-phase clinical symptoms of AR. Modification of the disease process results in significant relief of symptoms and leads to fewer disease exacerbations.

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Topical glucocorticosteroids in rhinitis: clinical aspects

Cited by 40 publications

References 71 publications

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Intranasal administration of oxytocin: Behavioral and clinical effects, a review

Glucocorticoids ameliorate TGF-β1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways

Targeting congestion in allergic rhinitis: The importance of intranasal corticosteroids

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