Topical<i>Hypericum perforatum</i>Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

Yadollah-Damavandi, Soheila; Chavoshi-Nejad, Mehdi; Jangholi, Ehsan; Nekouyian, Noushin; Hosseini, Sahar; Seifaee, Amin; Rafiee, Shima; Karimi, Hossein; Ashkani-Esfahani, Soheil; Parsa, Yekta; Mohsenikia, Maryam

doi:10.1155/2015/245328

Cited by 42 publications

(33 citation statements)

References 15 publications

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“…1 [62, 65–70]; 2 [53, 76–78, 138–152]; 3 [66, 68, 93, 97, 98, 100, 153–157]; 4 [158]; 5 [38, 93, 118, 119, 123–126, 157, 159–169]; 6 [170]; 7 [171]; 8 [172]; 9 [102, 103, 173]; 10 [174];; 11 [93]; 12 [93, 117–119]; 13 [167] 14 [65, 69, 175]; 15 [76, 79, 139–141, 151, 177, 178, 176, 179]; 16 [97]; 17 [120–122]; 18 [68]; 19 [78, 138, 152, 170]; 20 [68, 102, 103]; 21 [160, 166, 180]; 22 [79, 149, 150]; 23 [168, 181]; 24 [82]; 25 [35, 37, 104]; 26 [182]; 27 [29, 57–63]; 28 [31, 32, 82, 84, 87, 88, 183, 184]; 29 [104]; 30 [81]; 31 [185]; 32 [29, 64, 186]; 33 […”

Section: Resultsmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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Background Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematically evaluate based on recent scientific literature, the potential of four medicinal plants to enrich the therapeutic options in pyoderma, canine atopic dermatitis, otitis externa, wounds and dermatophytosis in dogs. Results Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold) , Hypericum perforatum L. agg. (St. John’s Wort) , Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia officinalis L. (Sage). According to the PRISMA statement through literature research on two online databases a total of 8295 publications was screened and narrowed down to a final 138 publications for which full-text documents were analyzed for its content resulting in a total of 145 references (21 clinical, 24 in vivo and 100 in vitro references). Conclusions All four plants were proven to have antibacterial and antifungal effects of a rather broad spectrum including antibiotic-resistant bacteria. This makes them an interesting new option for the treatment of pyoderma, otitis externa, infected wounds and dermatophytosis. Marigold, St. John’s Wort and Chamomile showed wound-healing properties and are thus promising candidates in line to fill the therapeutic gap in canine wound-healing agents. St. John’s Wort and Chamomile also showed anti-inflammatory and other beneficial effects on healthy skin. Due to the wide range of beneficial effects of these medicinal plants, they should be taken into account for the treatment of dermatologic diseases in dogs at least in future clinical research. Electronic supplementary material The online version of this article (10.1186/s12917-019-1854-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

et al. 2019

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“…Parts were embedded in a cylindrical paraffin block. Isotropic uniformly random (IUR) sections of the blocks with 5 μm and 15 μm width were obtained 16 and blemished with both Hedenhain’s azan and hematoxylin-eosin stains.…”

Section: Methodsmentioning

confidence: 99%

The Healing Effect of Plantago Major and Aloe Vera Mixture in Excisional Full Thickness Skin Wounds: Stereological Study

Ashkani-Esfahani

Khoshneviszadeh

Noorafshan

et al. 2019

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BACKGROUNDPrevious studies indicated that both Plantago major and Aloe vera have anti-inflammatory, tissue regeneration, antioxidant, and immune-stimulatory effects. It is assumed that a mixture of these two herbal medicines may provide a potent material in treatment of skin wound injuries. Therefore, in this study we investigated the effects of Plantago major and Aloe vera mixture in the process of wound healing in rat models according to stereological parameters. METHODSIn an experiential study, 36 male Sprague-Dawley rats (200±20 g) were randomly assigned into three groups (n=12): The control group which received no treatment, gel base treated group, and the 5% Plantago major and 5% Aloe vera mixture gel treated group (PA group). Treatments were done every 24 hrs for 15 days. Wound closure rate, volume densities of the collagen bundles and the vessels, vessel's length density and mean diameter, and fibroblast populations were estimated using stereological methods. RESULTS PA treated group showed faster wound closure rate in comparison with control and gel-base groups (p<0.05). Numerical density of fibroblasts, volume density of collagen bundles, mean diameter, and volume densities of the vessels in PA group were significantly higher than the control and the gel-base treated groups (p<0.05). CONCLUSIONWe showed that Plantago major and Aloe vera mixture has the ability to improve wound healing by enhancing fibroblast proliferation, collagen bundle synthesis and re-vascularization in skin injuries.

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“…The clinical efficacies of H. perforatum extracts in the therapy of mild to moderate depression have been confirmed in many studies (Lecrubier et al, 2002 ; Butterweck, 2003 ). Many other important pharmaceutical properties of H. perforatum including antiviral (Schinazi et al, 1990 ), anticancer (Agostinis et al, 2002 ), neuroprotective (Silva et al, 2004 ), antioxidant (Silva et al, 2005 ), and wound healing (Yadollah-Damavandi et al, 2015 ) activities have also been reported. Since treating humans and animals with H. perforatum extracts does not result in any serious adverse side effects (Trautmann-Sponsel and Dienel, 2004 ), use of this medicinal herb has increased dramatically during the past decade.…”

Section: Introductionmentioning

confidence: 99%

A Perspective on Hypericum perforatum Genetic Transformation

2016

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Hypericum perforatum (St John's wort) is a reservoir of diverse classes of biologically active and high value secondary metabolites, which captured the interest of both researchers and the pharmaceutical industry alike. Several studies and clinical trials have shown that H. perforatum extracts possess an astounding array of pharmacological properties. These properties include antidepressant, anti-inflammatory, antiviral, anti-cancer, and antibacterial activities; and are largely attributed to the naphtodianthrones and xanthones found in the genus. Hence, improving their production via genetic manipulation is an important strategy. In spite of the presence of contemporary genome editing tools, genetic improvement of this genus remains challenging without robust transformation methods in place. In the recent past, we found that H. perforatum remains recalcitrant to Agrobacterium tumefaciens mediated transformation partly due to the induction of plant defense responses coming into play. However, H. perforatum transformation is possible via a non-biological method, biolistic bombardment. Some research groups have observed the induction of hairy roots in H. perforatum after Agrobacterium rhizogenes co-cultivation. In this review, we aim at updating the available methods for regeneration and transformation of H. perforatum. In addition, we also propose a brief perspective on certain novel strategies to improve transformation efficiency in order to meet the demands of the pharmaceutical industry via metabolic engineering.

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TopicalHypericum perforatumImproves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

Cited by 42 publications

References 15 publications

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review

The Healing Effect of Plantago Major and Aloe Vera Mixture in Excisional Full Thickness Skin Wounds: Stereological Study

A Perspective on Hypericum perforatum Genetic Transformation

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