Topical mitomycin-C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery

A Preliminary Study on Possible Effects of Mitomycin-C on the Collagen Content of Penis in Rat

“…Other studies on mitomycin-C have shown its efficacy in preventing fibroblast proliferations and the development of fibrosis after myringotomy and trabeculectomy, thus improving the success rate of these procedures. Heran et al [20] showed topical mitomycin-C for recalcitrant esophageal strictures.…”

Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

“…Successful results were obtained in clinical and experimental researches related with mitomycin-c, an antimytotic agent which inhibits the fibroblastic activity [8,24]. But differences in severity and degree of burn set forth that one single chemical substance or surgical method cannot solve the problem.…”

“…Today some chemical agents, dilatation, stent applications and surgical treatment options are used for treatment [5,6]. In experimental models, some agents such as vitamin C and E, heparin, mitomycin, caffeic acid phenethyl ester, epidermal growth factor, interferon g, sphingosylphosphorylcholine, penicillamine, estradiol and progesterone are found to be successful but a current protocol could not be formed yet [7][8][9][10][11][12][13][14]. Difficulties in application of the experimental agents, limitations in clinical usage and different mechanisms of action are the disadvantages of these models.…”

Topical mitomycin-C for the treatment of anal stricture

“…Furthermore, the application of topical mitomycin-C also has been well studied in both animals [21] and humans [9,10] with laryngotracheal stenoses, albeit with varying degrees of success [11]. More recently, topical mitomycin-C has been shown to improve esophageal strictures refractory to repeated intraluminal dilatations [12][13][14][15]. Finally, there is anecdotal evidence of its positive effects in the treatment of both urethral [16] and vaginal [17] strictures.…”

“…Mitomycin-C, a chemotherapeutic agent that is known to inhibit RNA and protein synthesis, has been shown to be particularly effective in the prevention of fibroblast proliferation that can lead to scarring [7]. It has been used topically to treat stricture at a variety of anatomical locations including the eye [8], the upper airway [9][10][11], the esophagus [12][13][14][15], the urethra [16], and the vagina [17]. However, there is no documented evidence of its use for anorectal stricture.…”