Topical non steroidal anti<i>inflammatory</i>drug (NSAIDs microemulsions: Rationale, review and future prospective

Veerma, Ram; Singh, Rajesh; Javed, Anam; Sharma, Hitesh Kumar

doi:10.4103/0973-8398.110929

Cited by 12 publications

(6 citation statements)

References 33 publications

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“…This resulted in the improved thermodynamic stability of the microemulsions. To stabilize the small‐sized dispersed droplets, there is a need for higher proportions of surfactants molecules . In organogels, the proportion of DW was above the critical limit to induce gelation …”

Section: Resultsmentioning

confidence: 99%

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

Pradhan

Sagiri

Singh

et al. 2013

J of Applied Polymer Sci

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This study has been designed to develop palm oil (PO) based organogels using span 80/tween 80 mixture (OG) as a gelator system by fluid-filled structure mechanism. The results suggested formation of organogels, emulsions, and microemulsions as the proportions of PO, OG and water were varied. The emulsions were found to be thermodynamically unstable as compared to the organogels and the microemulsions. Accelerated thermal stability test suggested that all the microemulsions and the organogels of only eight compositions were stable. The organogels showed viscoelastic property while the microemulsions showed viscous flow behavior. Both the organogels and the microemulsions were found to be highly hemocompatible and nonirritant. The antimicrobial efficiency of the ciprofloxacin HCl-loaded formulations showed equivalent efficiency as compared to marketed formulations. The rates of drug release from the organogels were found to be relatively slower as compared to the microemulsions. The preliminary studies suggested that the developed organogel and microemulsion-based formulations may be tried for topical delivery of antimicrobials.

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Section: Resultsmentioning

confidence: 99%

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

Pradhan

Sagiri

Singh

et al. 2013

J of Applied Polymer Sci

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“…These colloidal systems are used either as vehicles alone or as drug solubilizers in drug dosage forms, e.g., gels [ 15 ]. Many studies confirm their positive effect on drug penetration or transdermal delivery [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Microemulsions as Solubilizers and Penetration Enhancers for Minoxidil Release from Gels

Špaglová

Čuchorová

Čierna

et al. 2021

Gels

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Micro- and nanoemulsions are potential drug solubilizers and penetration enhancers through the high surfactant/co-surfactant content. This study aimed to evaluate the influence of minoxidil (MXD) solubilized in the microemulsions (MEs) on drug release by in vitro/ex vivo diffusion through the semi-permeable membrane Spectra/Por® (Spectrum Laboratory, Gardena, CA, USA) and porcine ear skin. Moreover, a residual amount of drug in the skin after ex vivo diffusion was evaluated. The reference MER, lecithin-containing MEL, and gelatin-containing MEG were characterized in terms of their size, polydispersity index, density, viscosity, electrical conductivity and surface tension. Based on the in vitro diffusion, it can be argued that MEL slowed down the drug release, while MER and MEG have no significant effect compared to the sample, in which propylene glycol (PG) was used as a solubilizer. Determination of the residual drug amount in the skin after 6 h of the ex vivo permeation was demonstrated as the most valuable method to evaluate the effectiveness of the ME’s application. The results indicate that the most optimal MXD permeation enhancers in alginate gel were the natural surfactants containing MEs. MXD solubilization in MEG and MEL had caused more than 5% of the drug remaining in the skin, which is almost a 1.5-fold higher amount compared to the reference gel.

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“…Few mechanisms of activity were suggested in order to elucidate micreomulsion penetration ability. High solubilization capacity of the drug in the microemulsion may increase its activity towards the skin by raising the drug gradient across the skin [ 46 ] and may favor skin partition [ 47 ]. Microemulsion ingredients also have a pivotal role in the beneficial dermal delivery; surfactants and cosurfactants are often penetration enhancers resulting in the decrease in the diffusional barrier of the stratum corneum [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

Greenwald

Frušić-Zlotkin

Soroka

et al. 2017

Oxidative Medicine and Cellular Longevity

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Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system. Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure. We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin. A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion. Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.

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Topical non steroidal antiinflammatorydrug (NSAIDs microemulsions: Rationale, review and future prospective

Cited by 12 publications

References 33 publications

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

Microemulsions as Solubilizers and Penetration Enhancers for Minoxidil Release from Gels

Curcumin Protects Skin against UVB‐Induced Cytotoxicity via the Keap1‐Nrf2 Pathway: The Use of a Microemulsion Delivery System

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