Topical noxythiolin antisepsis. Report of a controlled trial

Bird, G.; Bunch, G. A.; Croft, C. B.; Hoffmann, D. C.; Humphrey, Christopher; Rhind, J R; Rosenberg, I. L.; Whittaker, M.; Wilkinson, A.R.; Hall, Robert A.

doi:10.1002/bjs.1800580611

Cited by 27 publications

(2 citation statements)

References 5 publications

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“…WOUND infection has been reported to occur in up to 30 per cent of all patients after appendicectomy (Bird et al, 1971), and the incidence may be as high as 63 per cent in perforated appendicitis (Leigh et al, 1974).…”

Section: Zn Cases With a Gangrenous Or Perforated Appendix The Infectmentioning

confidence: 99%

One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placebo

Donovan

Ellis

Gatehouse

et al. 1979

Journal of British Surgery

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Two hundred and fifty patients were admitted to a prospective randomized trial of single dosage prophylaxis against wound infection after appendicectomy. There were 12 exclusions, 72 patients received placebo, 81 received 600 mg i.m. clindamycin phosphate and 85 received 1 1 g i.m. cefazolin sodium, the agent being given in the anaesthetic room. Clindamycin produced a significant reduction in the overall rate of wound infection from 33 per cent in the controls to 17 per cent. In cases with a gangrenous or perforated appendix the infection rate in controls was 78 per cent; this was reduced to 44 per cent by a single dose of clindamycin. Cefazolin significantly reduced the number of aerobic organisms isolated from wound infections, but did not significantly reduce the incidence of wound infection. We conclude that anaerobic organisms are more important than faecal aerobic organisms in the pathogenesis of wound infection after appendicectomy.

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Section: Zn Cases With a Gangrenous Or Perforated Appendix The Infectmentioning

confidence: 99%

One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placebo

Donovan

Ellis

Gatehouse

et al. 1979

Journal of British Surgery

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“…trials [11,[22][23][24][25][26][27][28] is shown in Table 1. There tends to be little difference between infection rates after removal of a normal or an uncomplicated acutely inflamed appendix among these studies.…”

Section: Incidencementioning

confidence: 99%

Antimicrobial prophylaxis in appendectomy patients

Gottrup

Hunt

1982

World j. surg.

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Infection commonly follows removal of the gangrenous or perforated appendix. However, if the appendix is normal or simply acutely inflamed, the rate of infection is low. The organisms most frequently isolated from the wound after appendectomy are Bacteroides (especiallyB. fragilis) andEscherichia coli. A combination of chemoprophylaxis effective against these 2 groups of organisms is the most rational choice of antimicrobial cover. Such antimicrobial cover should be given to all patients with a gangrenous or perforated appendix and to all other patients with appendicitis who have compromised immune systems. Prophylaxis is probably unnecessary in patients with a normal immune system who present with uncomplicated appendicitis.

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Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

Heal

Banks

Lepper

et al. 2016

Cochrane Database of Systematic Reviews

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Topical noxythiolin antisepsis. Report of a controlled trial

Abstract: Noxythiolin powder, 600 mg., deposited in the layers of the abdominal wall of right iliac fossa musclesplitting incisions after appendicectomy seemed to be without serious side‐effects. However, no benefit was observed.

Cited by 27 publications

References 5 publications

One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placebo

One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placebo

Antimicrobial prophylaxis in appendectomy patients

Topical antibiotics for preventing surgical site infection in wounds healing by primary intention

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