Topical simvastatin: Preclinical evidence for a treatment of skin inflammatory conditions

Otuki, Michel Fleith; Pietrovski, Evelise Fernandes; Cabrini, Daniela Almeida

doi:10.1016/j.jdermsci.2006.04.006

Cited by 24 publications

(21 citation statements)

References 10 publications

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“…In addition, these studies in animal models provide evidence that statins are able to inhibit both acute and chronic inflammation in a cholesterol‐independent manner. This work further strengthens the evidence for the anti‐inflammatory effect of statins 27 …”

Section: Anti‐inflammatory Effectsupporting

confidence: 84%

Statins in dermatology

Jowkar

Namazi

2010

Int J Dermatology

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Statins are competitive inhibitors of 3-hydroxy-3-methylyglutaryl-coenzyme A reductase and reduce low-density lipoprotein-C levels. Statins are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Statins possess anti-inflammatory, immunomodulatory, antioxidant, metabolic, and possible anticancer effects. Statins are reported to be effective against psoriasis, dermatitis, graft-versus-host disease, uremic pruritus, vitiligo, and hirsutism. Topical forms of statins are employed in the treatment of acne, seborrhea, rosacea, and rhinophyma. Animal studies show the beneficial effect of statins against contact dermatitis and wound healing. They have promising anti-HIV effects as well. This article succinctly reviews the various cellular and molecular effects of statins, their applications in cutaneous medicine and their side effects.

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Section: Anti‐inflammatory Effectsupporting

confidence: 84%

Statins in dermatology

Jowkar

Namazi

2010

Int J Dermatology

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“…The oedema formed from the topical application of TPA is due to an inflammatory cascade triggered by protein kinase C (PKC) direct activation, resulting in vascular permeability increase, oedema formation and leukocytes infiltration [12]. The topical treatment with simvastatin inhibited both events, oedema formation and neutrophils migration revealed by the MPO enzymatic activity and histological analysis in the acute model as previously described by Otuki et al [6].…”

Section: Discussionmentioning

confidence: 77%

Simvastatin ointment, a new treatment for skin inflammatory conditions

Adami

Prudente

Mendes

et al. 2012

Journal of Dermatological Science

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“…It has been shown recently that simvastatin, dose-dependently and comparably to indomethacin, reduces polymorphonuclear leukocyte infiltration in a standard model of an acute local inflammation and enhances the regeneration of endothelial cells via VEGF secretion in injured arteries [21]. A study on the application of topical simvastatin to croton oil-induced contact dermatitis in male Swiss mice found reduced edema, polymorpho nuclear leukocyte infiltration and erythema [22]. Additionally, there is some evidence that statins may be beneficial in reducing the severity of psoriasis.…”

Section: Statins and Inflammationmentioning

confidence: 99%

Statins as potential therapeutic agents for healing disorders

Stojadinović

Lebrun

Pastar

et al. 2010

Expert Review of Dermatology

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Statins, HMG-CoA reductase inhibitors, are common cholesterol-lowering drugs. Recent studies suggest that statins may have potential as novel treatments for diverse conditions, ranging from sepsis and inflammatory diseases to chronic wounds and bone fractures. The diverse pleiotropic actions of statins are probably related to reduced isoprenylation of downstream targets of the mevalonate pathway and their binding to several nuclear hormone receptors. Statins exert their anti-inflammatory effect by inhibiting the release of C-reactive peptide, chemokines, cytokines and adhesion molecules, which may make them a powerful addition to the dermatologic antiinflammatory medication arsenal. Along with reducing inflammation, statins have the potential to heal chronic wounds by decreasing farnesyl pyrophosphate, facilitating vascular relaxation, promoting neovascularization and reducing bacterial load. A review of the literature elucidates that route of administration, dose and type of statin appear to impact the outcome. A better understanding of their effects at the cellular and molecular level in skin is necessary for their future use.

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Topical simvastatin: Preclinical evidence for a treatment of skin inflammatory conditions

Cited by 24 publications

References 10 publications

Statins in dermatology

Statins in dermatology

Simvastatin ointment, a new treatment for skin inflammatory conditions

Statins as potential therapeutic agents for healing disorders

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