Topical Therapies in Hyperhidrosis Care

Pariser, David M.; Ballard, Angela

doi:10.1016/j.det.2014.06.008

Cited by 46 publications

(49 citation statements)

References 20 publications

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“…In terms of the onset of efficacy, previous studies have noted the efficacy of AC for hyperhidrosis in 1 to 2 weeks. 11,19 In our study, the clinical efficacy of both AS and AC was observed at a median time of 1.14 weeks, which is similar to the results reported in previous literature.…”

Section: Discussionsupporting

confidence: 90%

“…9 The mechanism of action of aluminum salt entails the precipitation of metal ions with mucopolysaccharides, forming a plug that obstructs the eccrine gland ducts and blocks perspiration. 10 Aluminum chloride (AC), a widely used aluminum salt for hyperhidrosis treatment, 8,11 can cause skin irritation due to the formation of hydrochloric acid in the presence of water. 12 As a result, some PH patients consider this issue a limiting factor for using AC as part of their treatment.…”

mentioning

confidence: 99%

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Efficacy and tolerability of 20% aluminum sesquichlorohydrate vs 20% aluminum chloride for the treatment of axillary hyperhidrosis: A randomized controlled trial

Thianboonsong

Kanokrungsee

Paichitrojjana

et al. 2020

Dermatologic Therapy

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This study evaluated the efficacy and tolerability of topical aluminum sesquichlorohydrate (AS) when compared to aluminum chloride (AC) as a treatment for primary axillary hyperhidrosis (PAH). Twenty subjects were included in this randomized, controlled, split-side 8-week study. All participants applied 20% AS and 20% AC lotions in their axillae (one treatment per axilla) every night for 2 weeks; next, the application was reduced to three times a week for 4 weeks. The assessment was performed using the sweating intensity visual scale (SIVS), hyperhidrosis disease severity score (HDSS), patient satisfaction score, and the appearance of adverse effects on weeks 0, 1, 2, 4, 6, and 8. Both AS as well as AC application showed positive results, significantly differing from the baseline, as assessed using SIVS, HDSS, and patient satisfaction score at every follow-up visit; however, no significant difference was observed between the AS and AC groups at any follow-up visit. The mean time of response was 1.14 weeks for both treatments. A side effect was observed in one subject (5%), who reported itching on the AC axilla. The therapeutic effects persisted even after reducing the frequency of application and lasted for at least 2 weeks after cessation of use. In conclusion, topical 20% AS demonstrated similar efficacy to topical 20% AC in the treatment of PAH, with a high safety profile.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Efficacy and tolerability of 20% aluminum sesquichlorohydrate vs 20% aluminum chloride for the treatment of axillary hyperhidrosis: A randomized controlled trial

Thianboonsong

Kanokrungsee

Paichitrojjana

et al. 2020

Dermatologic Therapy

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“…Antiperspirants are considered the first-line therapy for IH. Specifically, aluminum chloride hexahydrate is the most common and effective topical medications used for mild to moderate IH [17]. However, the use of these topicals can have some disadvantages such as irritant or allergic contact dermatitis, inadequate long-term efficacy.…”

Section: Resultsmentioning

confidence: 99%

“…Idiopathic palmar hyperhidrosis is a disabling condition of unknown etiology, although hyperactivity of the sympathetic fibers that pass through the thoracic sympathetic ganglia T2 and T3 has been reported [32]. Topical medications [17], iontophoresis [33], oral oxybutynin [34], and surgical management [16] have been proposed for the treatment of this focal hyperhidrosis.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

Martina

Diotallevi

Radi

et al. 2021

Toxins

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Botulinum toxin is a superfamily of neurotoxins produced by the bacterium Clostridium Botulinum with well-established efficacy and safety profile in focal idiopathic hyperhidrosis. Recently, botulinum toxins have also been used in many other skin diseases, in off label regimen. The objective of this manuscript is to review and analyze the main therapeutic applications of botulinum toxins in skin diseases. A systematic review of the published data was conducted, following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Botulinum toxins present several label and off-label indications of interest for dermatologists. The best-reported evidence concerns focal idiopathic hyperhidrosis, Raynaud phenomenon, suppurative hidradenitis, Hailey–Hailey disease, epidermolysis bullosa simplex Weber–Cockayne type, Darier’s disease, pachyonychia congenita, aquagenic keratoderma, alopecia, psoriasis, notalgia paresthetica, facial erythema and flushing, and oily skin. Further clinical trials are still needed to better understand the real efficacy and safety of these applications and to standardize injection and doses protocols for off label applications.

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“…Topical treatments (aluminum chloride and other metal salts) and glycopyrrolate are available. 11 Orally, there are anticholinergic agents like glycopyrrolate and methantheline that compete with muscarinic receptors. Of note, oxybutynin is one of the most used agents in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Oxybutynin as an alternative treatment for hyperhidrosis

Delort

Marchi

Corrêa

2017

An. Bras. Dermatol.

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Hyperhidrosis is the excessive production of sweating, which can be primary and focal or secondary to various pathologies. The exact cause of primary focal hyperhidrosis is still unknown, although a genetic basis is recognized, and its prevalence varies from 1% to 2.8%. The most affected sites are the armpits, palms, soles and face. It causes much discomfort, affects the quality of life, and is estimated to be undervalued by health professionals. Many treatment options are proposed, both clinical and surgical. The aim of this review is to focus on the treatment of hyperhidrosis with oxybutynin, an anticholinergic drug originally used to control overactive bladder.

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Topical Therapies in Hyperhidrosis Care

Cited by 46 publications

References 20 publications

Efficacy and tolerability of 20% aluminum sesquichlorohydrate vs 20% aluminum chloride for the treatment of axillary hyperhidrosis: A randomized controlled trial

Efficacy and tolerability of 20% aluminum sesquichlorohydrate vs 20% aluminum chloride for the treatment of axillary hyperhidrosis: A randomized controlled trial

Therapeutic Use of Botulinum Neurotoxins in Dermatology: Systematic Review

Oxybutynin as an alternative treatment for hyperhidrosis

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