Topical tocopherol for treatment of reticular oral lichen planus: a randomized, double‐blind, crossover study

Bacci, Christian; Vanzo, Veronica; Frigo, Anna Chiara; Stellini, Edoardo; Sbricoli, Luca; Valente, Marialuisa

doi:10.1111/odi.12573

Cited by 15 publications

(19 citation statements)

References 38 publications

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“…All 25 examined studies were randomized controlled trials; 22 of these were parallel group studies, 1 was a crosssectional study [21] and 2 were split-mouth design studies [11,12]. Furthermore, 4 were single-blind studies [14,19,24,25] and 9 were double-blind studies [10,16,[20][21][22][23][26][27][28]. Table 1 and Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Among all the studies, 7 compared active treatment with a placebo [10,20,21,23,28,29], and one of these studies compared placebos with multiple treatments [30]. A total of 14 clinical trials compared two different active treatments [11-13, 15-18, 22, 26, 27, 31-34]; 3 studies compared two different drugs belonging to the same class [19,26,27]; finally, one study compared two different routes of administration of the same drug [14].…”

Section: Methodsmentioning

confidence: 99%

“…In the analysed literature, the most frequently recurrent therapy was based on the use of topical corticosteroids [12-19, 22, 24, 25, 30-34], followed by photo-dynamic therapy [13,17,30,[32][33][34], then by treatment with calcineurin inhibitors, such as tacrolimus and pimecrolimus [15,16,26,27,31], and finally by topical therapy with curcumin gel [18,22,23]. We also observed the use of various other types of intervention, namely cryotherapy [12], ozone therapy [30], excisional surgery [11], inhibitors of neo-angiogenesis [24], tocopherol [21], hydroxychloroquine [10], chamomile [28], hyaluronic acid [29], and Gluscosides of Paeony Capsule (GPC) [25].…”

Section: Methodsmentioning

confidence: 99%

“…It should be noted that some studies also excluded smokers [11][12][13] or heavy drinkers of alcohol [11] and patients with genital or skin lichenoid lesions [14][15][16][17][18], or patients affected by other types of oral lesions, different from those caused by OLP [19][20][21]. Finally, all trials using curcumin excluded patients with a history of gastric or duodenal ulcers, due to the irritative effect of turmeric on gastro-intestinal mucosa, and patients undergoing orthodontic treatment [22,23].…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…• Tocopherol, an important antioxidant, is able to contribute to the integrity of the cell membrane. According to a cross-sectional study conducted by Bacci et al (2017), tocopherol could significantly reduce the extent of the lesions in OLP, without, however, leading to an improvement in symptoms [21].…”

Section: Other Pharmacological Treatmentsmentioning

confidence: 99%

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Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods:We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results:A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion:Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations. atrophic-erosive type, but are rarely present in reticular forms [3].It is important to distinguish OLP from oral lichenoid lesions, which can be similar in appearance, but the latter represent a reaction to specific causal factors (e.g. dental materials, traumas, drugs) [5].Managing OLP is aimed at reducing symptoms and the manifestation of lesions, characterized by periods of exacerbation and quiescence. The first-line treatment is represented by the use of topical corticosteroids, although other effective therapies, like photodynamic therapy and the use of calcineurin inhibitors have recently been made available. MATERIALS AND METHODSWe examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus

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