Topical Treatment of Eyebrow Hypotrichosis with Bimatoprost 0.03% Solution: Case Report and Literature Review

Riahi, Ryan R; Cohen, Philip R.

doi:10.7759/cureus.2666

Cited by 6 publications

(12 citation statements)

References 13 publications

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“…Improvement in eyebrow hypotrichosis in this clinical trial is consistent with previous studies. Both concentrations provided significantly greater improvement in eyebrow growth compared to baseline, without serious side effects …”

Section: Discussionmentioning

confidence: 90%

“…Bimatoprost 0.03% was accidentally found to cause eyelash hypertrichosis as an adverse effect among glaucoma patients, leading to approval by the United States Food and Drug Administration (FDA) as a treatment of eyelash hypotrichosis . Subsequently, the 0.03% formulation has been experimented in various clinical studies of eyebrow hypotrichosis, including four case reports and four randomized controlled trials, which revealed the efficacy and safety of this concentration in enhancing eyebrow growth …”

Section: Introductionmentioning

confidence: 99%

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Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study

Suchonwanit

Harnchoowong

Chanasumon

et al. 2019

J of Cosmetic Dermatology

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Background Previous studies have proven the efficacy and safety of 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis; however, there is no comparison study between both concentrations. Aims To compare the efficacy and safety between 0.01% and 0.03% bimatoprost for the treatment of eyebrow hypotrichosis. Patients/Methods This prospective, randomized, double‐blind, split‐face clinical study was conducted in 30 patients with eyebrow hypotrichosis. Each side of eyebrow of individual patients was randomly assigned for 0.01% and 0.03% bimatoprost, applied on each eyebrow once daily. Eyebrow density, diameter, the Global Eyebrow Assessment scale, 7‐point rating scale, and patient satisfaction were evaluated. Side effects were also recorded. Results Both 0.01% and 0.03% bimatoprost significantly improved eyebrow density and diameter (P < .05), although there were no statistically significant differences in changes in eyebrow density and diameter from baseline between both concentrations (P = .96 and .84, respectively). Additionally, patients significantly preferred 0.03% bimatoprost in terms of clinical improvement and satisfaction (P = .04 and .003, respectively). Conclusions Both 0.01% and 0.03% bimatoprost are effective and safe for the treatment of eyebrow hypotrichosis. Bimatoprost 0.03% is superior to its 0.01% counterpart, albeit without statistical significance.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study

Suchonwanit

Harnchoowong

Chanasumon

et al. 2019

J of Cosmetic Dermatology

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“…As examples, the growth rate of the tiny hairs of eyebrows, their respective durations of growth/arrest phases (Anagen, Telogen) have not been investigated, up to our knowledge. In some clinical rare cases, a strong rarefaction of hairs (hypotrichosis) can be observed .…”

Section: Introductionmentioning

confidence: 99%

“…Tel. : +33 149795334; fax: +33 149795142; e-mail: frederic.flament@rd.loreal.com rare cases, a strong rarefaction of hairs (hypotrichosis) can be observed [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Morphometric characteristics of feminine eyebrows: variations with ethnicities and age

Flament

Seyrek

Francois

et al. 2019

Intern J of Cosmetic Sci

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Objective To explore some morphological features of the eyebrows of women of different ethnicities and ages. Materials and Methods Standard digital photographs of 3600 women of six ethnicities, aged 18–84 years, previously used to describe the morphology of the human eyes, allowed us to focus on their eyebrows, as supplementary and opportunistic study. Photographs of both eyebrows were analysed partly by manual markings and automatically by dedicated algorithms. Six parameters of the eyebrows were recorded: length, waviness/curvature, oblique aspect, size (vertical height), total surface and hair coverage (density). Results Most criteria present ethnic specificities. These are: length (longer eyebrows of Indian, shorter among African women); waviness where the straighter eyebrows were found among Chinese and Japanese women. In general, the longer the eyebrows, the higher their waviness and vice versa. Thickness (or height) of the eyebrows presents a wide ethnic variability as well as hair coverage, where African women present the lower hair density, inversely to Indian women. The same holds true with regard to the total surface of eyebrows, of a large variability (by about four times). Some criteria appear more individually dependent than ethnic‐specific, such as the oblique positioning, at the exception of Indian women with less oblique eyebrows. In all subjects, the criteria of both eyebrows (Left vs. Right) were found to be highly correlated (r > 0.7, P < 0.001). Conclusion The present investigation brings new findings on a scarcely studied facial element, the morphologic features of which are, for most, ethnic‐dependent. As applied consequences, the results of the present work pave the road to better adapt adorning procedures of the eyebrows vis‐à‐vis ethnic and age specificities.

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Comparative study of the efficacy and safety of topical minoxidil 2% versus topical bimatoprost 0.01% versus topical bimatoprost 0.03% in treatment of eyebrow hypotrichosis: a randomized controlled trial

Zaky¹,

Hashem²,

Mahfouz³

et al. 2023

Arch Dermatol Res

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Eyebrows are an important feature of facial identity and communications in human beings as well as an important eye defense shield from dust and foreign bodies. To compare the efficacy and safety between 0.01%, 0.03% bimatoprost and minoxidil 2% in gel formulations for eyebrow enhancement. Sixty eligible subjects were female or male, aged 18 years or older with eyebrow hypotrichosis, defined as either a Grade 1 or 2 on the Global Eyebrow Assessment (GEBA) scale. Patients were randomized into 3 groups using block randomization. Group a (20 patients) applied topical 0.03% bimatoprost gel once daily onto both eyebrows, group b (20 patients) applied topical 0.01% bimatoprost gel once daily onto both eyebrows while group c (20 patients) applied topical minoxidil 2% gel once daily onto both eyebrows. A significant improvement in GEBA score was reported in all the three groups after treatment (P ≤ 0.001); however, there was no statistically significant difference between the three groups (P1 = 0.091; P2 = 0.102; P3 = 0.663). Bimatoprost is equally efficacious as minoxidil in enhancement of eyebrows with a more favorable response produced by the 0.03% concentration.

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Topical Treatment of Eyebrow Hypotrichosis with Bimatoprost 0.03% Solution: Case Report and Literature Review

Cited by 6 publications

References 13 publications

Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study

Comparison of the efficacy and safety of using 0.01% versus 0.03% bimatoprost for the treatment of eyebrow hypotrichosis: A randomized, double‐blind, split‐face, comparative study

Morphometric characteristics of feminine eyebrows: variations with ethnicities and age

Comparative study of the efficacy and safety of topical minoxidil 2% versus topical bimatoprost 0.01% versus topical bimatoprost 0.03% in treatment of eyebrow hypotrichosis: a randomized controlled trial

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