Topical treatment of radiation-induced dermatitis: current issues and potential solutions

Iacovelli, Nicola Alessandro; Torrente, Yvan; Ciuffreda, A.R.; Guardamagna, Vittorio; Gentili, Marta; Giacomelli, Luca; Sacerdote, Paola

doi:10.7573/dic.2020-4-7

Cited by 47 publications

(61 citation statements)

References 82 publications

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“…However, chronic radiation dermatitis can also result in profound atrophy and poor vascular supply to the involved skin, which may complicate the wound healing of biopsies and excisions. Treatments of chronic radiation dermatitis includes topical corticosteroids, surgical skin reconstruction, and wound dressings (20). Our patient's SCCs were treated with excision or electrodessication and curettage, and her AKs were treated with cryotherapy given her intolerance to field therapy in the past.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma (SCC) and Chronic Radiation Dermatitis Associated with Childhood Ionizing Radiation Exposure: Case Report with Review of the Literature

Yue¹,

Lombardi²,

Sodagum³

et al. 2021

J Skin Stem Cell

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Introduction: Squamous cell carcinoma (SCC) is one of the most common types of skin cancer in Caucasians, but the role played by ionizing radiation (IR) exposure in its etiology is unclear. Case Presentation: This study presents a patient with SCC, actinic keratoses, and radiation dermatitis of the feet with a distant history of IR exposure from a shoe-fitting fluoroscope. It is likely the fluoroscope’s IR contributed to the etiology of these manifestations. Conclusions: Patients with a history of repeated IR exposure, particularly from older, unregulated sources such as a shoe-fitting fluoroscope, should be monitored with a high index of suspicion for skin cancer and other related problems.

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Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma (SCC) and Chronic Radiation Dermatitis Associated with Childhood Ionizing Radiation Exposure: Case Report with Review of the Literature

Yue¹,

Lombardi²,

Sodagum³

et al. 2021

J Skin Stem Cell

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“…Entretanto, ambas as modalidades provocam alterações dermatológicas que demandam de cuidados durante o tratamento oncológico. No cenário do câncer de mama, estima-se que mais de 70% das mulheres irradiadas apresentam alguma radiodermite 30 .…”

Section: Epidemiologiaunclassified

Alterações Dermatológicas Durante Tratamento Oncológico de Mulheres com Câncer de Mama: Estudo em Prontuários Clínicos

Kameo

Barbosa-Lima

Fonseca

et al. 2021

Rev. Bras. Cancerol.

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Introdução: Diversos efeitos colaterais podem acometer a pele e seus anexos durante o tratamento oncológico de mulheres com câncer de mama, comprometendo a terapia. Objetivo: Identificar a ocorrência de alterações dermatológicas durante o tratamento oncológico de mulheres com câncer de mama. Método: Estudo documental e retrospectivo, de cunho quantitativo, com uso de dados secundários obtidos por meio de 190 prontuários clínicos (n=190) de um serviço privado de oncologia. Resultados: As participantes apresentaram média de idade de 53 anos (±11,2), com diagnóstico histopatológico de carcinoma ductal invasivo (85,8%). Todas foram submetidas à quimioterapia, 65,3% à mastectomia radical e 34,2% à radioterapia. As alterações dermatológicas identificadas e as ocorrências verificadas na amostra foram alopecia (94,2%), hiperpigmentação (48,4%), prurido (36,3%), eritema (6,8%), descamação (25,8%) e alterações ungueais (77,9%). Ao todo, foram identificadas 550 alterações dermatológicas, resultando em uma média de 2,9 (±1,3) por paciente. A radioterapia esteve associada a uma maior ocorrência de eritema (p<0,001) e mulheres expostas a taxanos apresentaram maior probabilidade de manifestar de alterações dermatológicas do que as não expostas (p<0,001), bem como fatores sociodemográficos não estiveram associados. Conclusão: A ocorrência de alterações dermatológicas identificadas nas participantes foi significativa, reforçando que essas manifestações podem ser frequentes em mulheres com câncer de mama durante o tratamento oncológico, requerendo medidas de prevenção e tratamento.

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“…It has been reported that nearly 90% of patients undergoing RT for breast cancer develop erythema-symptomatic RID ( Geara et al, 2018 ). RID can induce significant discomfort, including fibrosis and skin pigmentation, negative effects on quality of life, and may even delay or prematurely end conventional cancer therapies such as RT or chemotherapy ( Iacovelli et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Jaungo, A Traditional Herbal Ointment, and the Water-in-Oil Type Non-Steroidal Moisturizer for Radiation-Induced Dermatitis in Patients With Breast Cancer: A Study Protocol for a Prospective, Randomized, Single-Blinded, Pilot Study

et al. 2021

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Background: Radiation-induced dermatitis (RID) is a common complication of radiation therapy (RT). Although it has a high prevalence and can even trigger the premature end of conventional cancer therapies, there is no standard management. This study aims to evaluate whether topical use of Jaungo (Shiunko), a traditional herbal ointment mainly composed of Lithospermi radix and Angelica sinensis, could reduce RID compared to the water-in-oil type non-steroidal moisturizer in patients with breast cancer.Methods: This is a prospective, single-blinded, randomized controlled pilot trial that investigates the effect of topical application of Jaungo for the prevention of RID in postoperative breast cancer patients scheduled for RT, in comparison with the non-steroidal moisturizer, with a random distribution of 50 patients across the two groups. RT will be administered for 5–7 weeks with a biological equivalent dose (BED10) of 60 Gy or more, and the interventions will be applied 3 times a day during RT duration. Participants will be assessed a total of nine times, including eight visits during the period of RT and one visit at a 2-week follow-up period after the end of treatment. The incidence and severity of RID, quality of life, skin reaction symptoms, and maximum pain related to RID will be measured. The incidence rate of grade 2 or higher RID using the Radiation Therapy Oncology Group (RTOG) in the two groups will be statistically compared as the primary outcome. The types and frequencies of adverse events will be also collected and evaluated. All assessments will be performed by independent radiology oncologists.Discussion: This trial is currently ongoing and is recruiting. This study will determine the preventive efficacy of Jaungo in RID with postoperative breast cancer patients and provide evidence in traditional Korean medicine clinical practice.

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Topical treatment of radiation-induced dermatitis: current issues and potential solutions

Cited by 47 publications

References 82 publications

Squamous Cell Carcinoma (SCC) and Chronic Radiation Dermatitis Associated with Childhood Ionizing Radiation Exposure: Case Report with Review of the Literature

Squamous Cell Carcinoma (SCC) and Chronic Radiation Dermatitis Associated with Childhood Ionizing Radiation Exposure: Case Report with Review of the Literature

Alterações Dermatológicas Durante Tratamento Oncológico de Mulheres com Câncer de Mama: Estudo em Prontuários Clínicos

Comparative Efficacy of Jaungo, A Traditional Herbal Ointment, and the Water-in-Oil Type Non-Steroidal Moisturizer for Radiation-Induced Dermatitis in Patients With Breast Cancer: A Study Protocol for a Prospective, Randomized, Single-Blinded, Pilot Study

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