Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products

Chen, Siang-An; Chen, Han-Min; Yao, Y. D.; Hung, Chi‐Feng; Tu, Chi‐Shun; Liang, Yao-Jen

doi:10.1016/j.ejps.2012.08.018

Cited by 131 publications

(75 citation statements)

References 38 publications

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“…An experimental study in vitro and in vivo has demonstrated a possible benefit of topical application of ALA alone or in combination with other anti-oxidant agents for diabetic wound healing [148]. In this study the expression of RAGE was attenuated in skin wound in diabetic animals when ALA was used in combination with other anti-oxidants agents for one week.…”

Section: Clinical Use Of Ala In Diabetesmentioning

confidence: 66%

Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

Gomes

Negrato²

2014

Diabetol Metab Syndr

230

164

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Alpha-lipoic acid is a naturally occurring substance, essential for the function of different enzymes that take part in mitochondria’s oxidative metabolism. It is believed that alpha-lipoic acid or its reduced form, dihydrolipoic acid have many biochemical functions acting as biological antioxidants, as metal chelators, reducers of the oxidized forms of other antioxidant agents such as vitamin C and E, and modulator of the signaling transduction of several pathways. These above-mentioned actions have been shown in experimental studies emphasizing the use of alpha-lipoic acid as a potential therapeutic agent for many chronic diseases with great epidemiological as well economic and social impact such as brain diseases and cognitive dysfunctions like Alzheimer disease, obesity, nonalcoholic fatty liver disease, burning mouth syndrome, cardiovascular disease, hypertension, some types of cancer, glaucoma and osteoporosis. Many conflicting data have been found concerning the clinical use of alpha-lipoic acid in the treatment of diabetes and of diabetes-related chronic complications such as retinopathy, nephropathy, neuropathy, wound healing and diabetic cardiovascular autonomic neuropathy. The most frequent clinical condition in which alpha-lipoic acid has been studied was in the management of diabetic peripheral neuropathy in patients with type 1 as well type 2 diabetes. Considering that oxidative stress, a imbalance between pro and antioxidants with excessive production of reactive oxygen species, is a factor in the development of many diseases and that alpha-lipoic acid, a natural thiol antioxidant, has been shown to have beneficial effects on oxidative stress parameters in various tissues we wrote this article in order to make an up-to-date review of current thinking regarding alpha-lipoic acid and its use as an antioxidant drug therapy for a myriad of diseases that could have potential benefits from its use.Electronic supplementary materialThe online version of this article (doi:10.1186/1758-5996-6-80) contains supplementary material, which is available to authorized users.

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Section: Clinical Use Of Ala In Diabetesmentioning

confidence: 66%

Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

Gomes

Negrato²

2014

Diabetol Metab Syndr

230

164

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“…The AuNPs were found within the range of 3-5 nm from transmission electron microscope images. 109 Lethal dosage (LD 50 ) of AuNPs was found to be greater than 2000 mg/kg. 110 Au NPs served as adjuvants to increase skin absorption with functional ability of anti-oxidants (Fig.…”

Section: Natural Polymer/metals Based Composites For Wound Healingmentioning

confidence: 98%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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Dermal tissue engineering focuses on the restoration of diseased and damaged tissues by using a combination of cells, biomaterials, and bioactive molecules. Inorganic substances like zeolites, clay, mesoporous silica, metals, and metal oxides are advanced materials used in wound healing research. They can improve the structural stability and bioactivity of bio polymeric scaffolds. Zeolites, clays, and mesoporous silica act as suitable carriers for drug delivery and when incorporated within scaffolds, serve as ideal matrices for promoting skin regeneration. This review focuses on various natural polymers/inorganic materials based composite scaffolds used for skin tissue engineering, highlighting their synthesis routes and mode of action by which wound healing is enhanced. Among the different inorganic materials used, the role of zeolites incorporated biocomposites for promoting blood coagulation, antibacterial effect; oxygen delivery to cells and wound healing are discussed in detail. The article thus includes recent attempts to explore the hidden potential of inorganic materials in dermal tissue engineering.

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“…[23,24] In particular, the effect of AuNPs combined with anti-oxidants has shown a notable acceleration in diabetic wound healing. [25,26] AuNPs have also been extensively incorporated to many consumer products such as cosmetics, soaps and dressings as a result of their surprisingly strong anti-oxidant, anti-microbial and antiinflammatory properties, which make them useful agents in the treatment against rheumatoid arthritis and topical wounds. [27À29] Furthermore, it has previously shown that AuNPs may be used in the future for the treatment of cutaneous infectious diseases or skin cancers.…”

Section: Please Scroll Down For Articlementioning

confidence: 99%

Comparative cytotoxicity evaluation of different size gold nanoparticles in human dermal fibroblasts

Mateo

Morales

Ávalos

et al. 2015

Journal of Experimental Nanoscience

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Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products

Cited by 131 publications

References 38 publications

Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

Comparative cytotoxicity evaluation of different size gold nanoparticles in human dermal fibroblasts

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