Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study

Palacios, J.M.; Blázquez-Sánchez, Nuria; Rivas-Ruiz, Francisco; Bernier, Miguel Aguilar; López, Belén Ramírez; Sánchez, María Encarnación Fernández; Troya-Martín, Magdalena de

doi:10.1016/j.ctim.2018.12.003

Cited by 9 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study we also found that levels of pro-inflammatory cytokines (IL-6, IL-17A, TNF-α and IL-1B) significantly decreased, while those of anti-inflammatory cytokine (IL-10) significantly increased. This data suggests that the consumption of EVOO with a high content of OC can have important anti-inflammatory effects, and it is consistent with the natural anti-inflammatory properties of OC [ 14 , 77 , 78 ]. It has been previously reported that one of the mechanisms underlying the anti-inflammatory properties of OC is the inhibition of the nuclear factor-κB (NF-kB) pathway [ 79 ], which in turn may not only reduce the levels of pro-inflammatory cytokines but also attenuate cortical cyclooxygenase-2 (COX-2) signaling [ 80 ].…”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study

et al. 2020

View full text Add to dashboard Cite

Extra virgin olive oil (EVOO) intake is associated with reduced cardiovascular risk, and its phenolic compound oleocanthal (OC) has anti-oxidant and anti-inflammatory properties. The cardiometabolic effects of EVOO with a high OC concentration have not been fully elucidated. We administered EVOO with a high OC concentration daily to 23 subjects with the metabolic syndrome (MetS) and hepatic steatosis (15 men and 8 women, age: 60 ± 11 years) for 2 months. Anthropometric data, metabolic parameters, hepatic steatosis (by fatty liver index, FLI), abdominal fat distribution (by ultrasound), and pro- and anti-inflammatory cytokines were assessed before and after the intervention. EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-α and IL-1B, while IL-10 increased. Maximum subcutaneous fat thickness (SFT max) also increased, with a concomitant decrease in the ratio of visceral fat layer thickness/SFT max. Correlation analysis revealed positive associations between changes in body weight and BMI and those in SFT max, along with an inverse association between changes in IL-6 and those in SFT max. In conclusion, ingestion of EVOO with a high OC concentration had beneficial effects on metabolic parameters, inflammatory cytokines and abdominal fat distribution in MetS subjects with hepatic steatosis, a category of patients at high cardiometabolic risk.

show abstract

Section: Discussionsupporting

confidence: 79%

“…Oleocanthal (OC) is a phenolic compound found mostly in EVOO which is responsible for its bitter taste, having strong anti-inflammatory properties based on the inhibition of cyclooxygenase (COX) [ 12 ]. For this reason, OC is recognized as a natural non-steroidal anti-inflammatory agent [ 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Oc blocks LPS-mediated inflammatory response and inhibits MMP-13 and ADAMTS-5 aggrecanase, enzyme that mediates cartilage aggrecan degradation in human primary OA chondrocytes, suggesting that Oc may be a promising agent for the treatment of inflammation in cartilage and a potential molecule to prevent disease progression [262]. The topical application of an oily fluid enriched with Oc achieves a greater reduction in post-photodynamic therapy cutaneous inflammation and a better treatment response, in comparison with the application of a conventional oily fluid [263]. Also, inhibiton of platelet aggregation by extra virgin OO was shown to be in correlation with amount of Oc [264].…”

Section: Oleocanthalmentioning

confidence: 99%

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

et al. 2019

View full text Add to dashboard Cite

The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a healthy way of eating and living nowadays. This kind of diet has been highly appreciated and is widely recognized for being associated with many favorable effects, such as reduced incidence of different chronic diseases and prolonged longevity. Although olive oil polyphenols present a minor fraction in the composition of olive oil, they seem to be of great importance when it comes to the health benefits, and interest in their biological and potential therapeutic effects is huge. There is a growing body of in vitro and in vivo studies, as well as intervention-based clinical trials, revealing new aspects of already known and many new, previously unknown activities and health effects of these compounds. This review summarizes recent findings regarding biological activities, metabolism and bioavailability of the major olive oil phenolic compounds—hydroxytyrosol, tyrosol, oleuropein, oleocanthal and oleacein—the most important being their antiatherogenic, cardioprotective, anticancer, neuroprotective and endocrine effects. The evidence presented in the review concludes that these phenolic compounds have great pharmacological potential, however, further studies are still required.

show abstract

“…In the hemostasis phase, the healing process is initiated by a series of mechanisms that are set in motion to produce the hemostatic clot, thanks to the activation of the coagulation factor cascade, which results in the formation of a fibrin matrix that serves as the basis for subsequent cellular infiltration [4]. This stage is followed by the inflammation dermatitis, or actinic keratosis [36][37][38]. Although numerous papers have been published in the past decades regarding the advantageous effects of EVOO, there is only limited scientific evidence available on the effects of polyphenols found in EVOO on tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

et al. 2023

View full text Add to dashboard Cite

Fibroblasts contribute to maintaining tissue integrity and homeostasis and are a key cell population in wound healing. This cell population can be stimulated by some bioactive compounds such as extra virgin olive oil (EVOO) polyphenols. The aim of this study was to determine the effects of hydroxytyrosol (htyr), tyrosol (tyr), and oleocanthal (ole) phenolic compounds present in EVOO on the proliferation, migration, cell cycle, and antigenic profile of cultured human fibroblasts. CCD-1064Sk human fibroblast cells were treated for 24 h with each polyphenol at doses ranging 10−5 to 10−9 M. Cell proliferation was evaluated using the MTT spectrophotometric technique, migration capacity by culture insert assay, and cell cycle and antigenic profile with flow cytometry. Cell proliferation was significantly increased by treatment with all compounds. The highest increases followed treatments with htyr or tyr at doses of 10−5 or 10−6 M and with ole at 10−6 and 10−7 M, and these compounds and doses were used for assays of antigenic profile, cell cycle, and migration. During the first few hours after treatment, increased fibronectin and α-actin expressions and greater cell migration were observed, with no cell cycle changes. In conclusion, these in vitro results suggest that phenolic compounds in EVOO might contribute to wound healing through action on fibroblasts related to tissue regeneration.

show abstract

Topical treatment with oleocanthal extract in reducing inflammatory reactions after photodynamic therapy: a prospective quasi-experimental pilot study

Cited by 9 publications

References 17 publications

Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study

Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study

Hydroxytyrosol, Tyrosol and Derivatives and Their Potential Effects on Human Health

The Benefits of Olive Oil for Skin Health: Study on the Effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on Human Fibroblasts

Contact Info

Product

Resources

About