Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis

Sirerol, J. Antoni; Feddi, Fatima; Mena, Salvador; Rodriguez, María L.; Sirera, Paula; Aupí, Miguel; Pérez, Salvador; Asensi, Miguel; Ortega, Ángel; Estrela, José M.

doi:10.1016/j.freeradbiomed.2015.03.027

Cited by 107 publications

(88 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The naturally-occurring compound pterostilbene, an analog of resveratrol in which metabolism is blocked by methylation of the 3- and 5-hydroxy groups, is also found in berry juices and has been studied as a more bioavailable alternative to resveratrol. Treatment of hairless mice with topical pterostilbene resulted in a dramatic decrease in both UV-induced erythema and KC tumor formation 129 .…”

Section: Introductionmentioning

confidence: 95%

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

Jeter

Bowles

Curiel‐Lewandrowski

et al. 2018

Cancer

View full text Add to dashboard Cite

Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival. As these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of the disease. Now is the time to apply that knowledge towards the design and clinical evaluation of new chemoprevention agents. Melanoma chemoprevention has the potential to dramatically reduce both the morbidity and high costs associated with treating patients with metastatic disease. In this work, scientific and clinical melanoma experts from the national Melanoma Prevention Working Group comprised of National Cancer Trials Network (NCTN) participants, discuss research aimed at discovering and developing (or re-purposing) drugs and natural products for the prevention of melanoma, and propose an updated pipeline for translating the most promising agents into the clinic. The mechanism of action, pre-clinical data, epidemiological evidence and results of available clinical trials are discussed for each class of compounds. Selected keratinocyte carcinoma chemoprevention studies are also considered, and a rationale for their inclusion is presented. These data are summarized in a table that lists the type and level of evidence available for each class of agents. Also included in the discussion is an assessment of additional research necessary and likelihood that a given compound might be a suitable candidate for a Phase III clinical trial within the next 5 years.

show abstract

Section: Introductionmentioning

confidence: 95%

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

Jeter

Bowles

Curiel‐Lewandrowski

et al. 2018

Cancer

View full text Add to dashboard Cite

show abstract

“…Resveratrol inhibited tumor promotion in the DMBA-TPA mouse-skin carcinogenesis model, possibly because (at least in part) of its anti-oxidant properties [199]. Resveratrol administration restored glutathione (GSH) levels, superoxide dismutase (SOD), GSH peroxidase, and catalase activities to control values (mice without UVB irradiation) [244]. Furthermore, resveratrol exerted an anti-oxidant effect with a reduction in H 2 O 2 and lipid peroxidation in the skin [202].…”

Section: Skin Cancermentioning

confidence: 99%

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

2018

View full text Add to dashboard Cite

“…Structural modification by substituting 2 hydroxyl groups by 2 methoxy groups in resveratrol has also been shown to improve its stability . Pterostilbene (3,5‐dimethoxy‐4′‐hydroxy‐ trans ‐stilbene; Pter), an analog of resveratrol, which contains 2 methoxy groups and one hydroxy group, has greater stability and longer half‐life compared to resveratrol.…”

Section: Resveratrolmentioning

confidence: 99%

“…Pterostilbene (3,5‐dimethoxy‐4′‐hydroxy‐ trans ‐stilbene; Pter), an analog of resveratrol, which contains 2 methoxy groups and one hydroxy group, has greater stability and longer half‐life compared to resveratrol. Studies have shown that this structural modification increases its lipophilicity resulting in improved membrane permeability and bioavailability, which leads to more effective anticancer properties than resveratrol against UVB radiation‐induced skin cancer …”

Section: Resveratrolmentioning

confidence: 99%

Protective molecular mechanisms of resveratrol in UVR‐induced Skin carcinogenesis

Aziz

2017

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

SummarySkin cancer is a major health problem worldwide. It is the most common cancer in the United States and poses a significant healthcare burden. Excessive UVR exposure is the most common cause of skin cancer. Despite various precautionary measures to avoid direct UVR exposure, the incidence of skin cancer and mortality related to it remains high. Furthermore, the current treatment options are expensive and have side effects including toxicity to normal cells. Thus, a safe and effective approach is needed to prevent and treat skin cancer. Chemopreventive strategy using naturally occurring compounds, such as resveratrol, is a promising approach to reduce the incidence of UVR-induced skin cancer and delay its progression. This review highlights the current body of evidence related to chemopreventive role of resveratrol and its molecular mechanisms in UVR-induced skin carcinogenesis. K E Y W O R D Schemoprevention, resveratrol, skin carcinogenesis, UVR | INTRODUCTIONSkin is the largest organ in the human body, which serves many essential functions including protection from environmental stressors, infections, and regulating body temperature and fluids. 1 In addition, it acts as a huge sensory receptor for touch, heat, cold, pain, and pressure.Furthermore, it is the first line of defense and provides immunological surveillance against germs, allergens, and irritants trying to enter the body. 2 Healthy skin is also vital for visual appearance and psychosocial communication. 3,4 Therefore, continuous preventive measures are required to protect skin against disfiguring, function impairing, or lifethreatening consequences.Skin is primarily composed of 3 layers (epidermis, dermis, and subcutaneous). The epidermis is the outer protective layer of skin, which consists of squamous and basal cells. Melanocytes are also found in epidermis, which are cells containing pigments and allow the skin to tan. The dermis which is just below the epidermis contains blood vessels, connective tissue, hair follicles, and sweat glands. The subcutaneous layer (also known as the hypodermis or subcutis) is the deepest layer of the skin containing fat cells and collagens. Skin cancer occurs when there is uncontrolled growth of abnormal cells in any of these 3 layers of skin. 5,6 Skin cancer is the most common cancer in the United States. 7,8 It has been reported that one in 5 Americans will develop skin cancer in their lifetime. 9-13 It poses significant healthcare burden, with estimated annual cost of treating nonmelanoma and melanoma skin cancer being $4.8 and $3.3 billion, respectively, in the United States. 8 Several factors can influence the risk of developing skin cancer such as excessive solar UV exposure, skin type, family and personal history of skin cancer, frequent use of tanning bed, multiple moles, history of sunburns, and others. 14 There are 3 most common forms of skin cancers that are distinguished by the types of cells affected. Most skin cancers arise from epidermal layer. Basal cell carcinoma is the most common type of ski...

show abstract

Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis

Cited by 107 publications

References 55 publications

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials

Chemically-Induced DNA Damage, Mutagenesis, and Cancer

Protective molecular mechanisms of resveratrol in UVR‐induced Skin carcinogenesis

Contact Info

Product

Resources

About