Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats

Abstract

Objective:The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Tetrapleura tetraptera in stem-bark.Materials and Methods:The healing activity was studied in 40 male rats using excision and incision wounds on normal and dexamethasone-suppressed wound healing. For each model, rats were divided in four groups as follows: control, dexamethasone, T. tetraptera and dexamethasone combined with T. tetraptera. Results: Data recorded exhibited a significant effect by the extract in the epithelialization time within 14 and 18 days of the normal and dexamethasone-induced healing delay rats, respectively (P < 0.05). The extract also significantly increased the wound tensile strength in dexamethasone treated rats. Histological examination of incision wounds of the extract-treated group showed many fibroblasts and the same rats presented significant cutaneous tensile strength, suggesting important collagen crosslinkage.Conclusion:This study illustrated an excellent potential of the bark of T. tetraptera therapy on dermal wound healing with a possible mechanism of action related to epithelialization, contraction, and tensile strength improvement.

Investigating the efficacy and safety of mineral smectite granules on wound healing

“…Natural products serve as an important type of therapeutic agents. A number of studies have evaluated the effects of plant extracts on wound healing, such as Opuntia flower extracts ( 5 , 22 ). However, a key limitation of plant extracts is the extraction process is complicated, leading to uncertain results.…”

In Vivo Wound Healing Effect of Water Extract of Stereospernum kunthianum Stem-Bark

“…Drugs, as well as surgical procedures, were conducted as previously described (Tsala et al, 2014). Accordingly, ketamine (Rotexmedica-Trittau-Germany), diazepam (Renaudin-France), dexamethasome (Guangdong Medecine and Health Products I/E corp.) nylon surgical treat size 1 (Agary Pharmaceutical Ltd.) were purchased from a local pharmacy store).…”

Anti-inflammation Study of Cellulose-Chitosan Biocomposite-Based Tetrapleura tetraptera (Taub) Dried Fruits Aqueous Extract

“…The aqueous fruit extract possesses analgesic and anticonvulsant properties [12]. The fruit has protective potential against stroke through modulation of redox and electrolyte imbalances, and attenuation of neurotransmitter dysregulation and other neurochemical dysfunctions and is a smooth muscle relaxant [13,14]. Tetrapleura tetraptera was reported in a review to contain various biologically active compounds such as hentriacontane, an anti-in ammatory agent and the avanone-naringenin a strong antioxidant [6].…”