Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion

Jafari, Abbas Ali; Ghasemnejad‐Berenji, Hojat; Nemati, Mohadeseh; Ghasemnejad‐Berenji, Morteza

doi:10.1016/j.ajem.2020.03.060

Cited by 23 publications

(25 citation statements)

References 27 publications

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“…Testicular torsion/detorsion-induced damage is an ischemia-reperfusion injury. Ischemia-reperfusion induces the formation of large amounts of reactive oxygen species, such as hydrogen peroxide, superoxide anion, and hydroxyl radical [ 7 – 10 ]. Increased production of reactive oxygen species can cause peroxidation of cell membrane lipids and damage both DNA and protein function, leading to cellular dysfunction and death [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism underlying testicular damage during torsion-detorsion is ischemia-reperfusion injury. Although the exact mechanisms of the injury have not been completely understood, excess reactive oxygen species produced during the ischemia-reperfusion play an important role in tissue damage [ 7 – 10 ]. Reactive oxygen species (mainly hydrogen peroxide, superoxide anion, and hydroxyl radical) cause tissular damage by oxidizing cellular membrane lipids, deoxyribonucleic acid (DNA), and proteins [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Attenuation Effect of Salvianolic Acid B on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

2022

Oxidative Medicine and Cellular Longevity

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During testicular ischemia-reperfusion, overproduction of reactive oxygen species is associated with testicular injury. We injected hydrogen peroxide (a representative of reactive oxygen species) into normal testis via the testicular artery. The experiment demonstrates that reactive oxygen species can cause spermatogenic injury. Salvianolic acid B, the most abundant bioactive component in Salvia miltiorrhiza Bunge, has been reported to possess a potent antioxidant activity. This study was conducted to evaluate the effect of salvianolic acid B on testicular ischemia-reperfusion injury in a rat testicular torsion-detorsion model. Rats were randomly separated into three groups, including 20 rats in each group: control group with sham operation, testicular ischemia-reperfusion group, and testicular ischemia-reperfusion + salvianolic acid B-treated group. In the testicular ischemia-reperfusion group, left testicular torsion of 720° for 2 hours was induced, and then testicular detorsion was carried out. Rats in the salvianolic acid B-treated group additionally had salvianolic acid B administered intravenously at detorsion. At 4 hours after detorsion, testes of 10 rats from each group were collected to analyze the protein expression of xanthine oxidase which catalyzes generation of reactive oxygen species and malondialdehyde concentration (an indirect indicator of reactive oxygen species). At 3 months after detorsion, testes of the remaining 10 rats from each group were collected to analyze spermatogenesis. Compared with the control group, xanthine oxidase protein expression and malondialdehyde concentration in ipsilateral testes of testicular ischemia-reperfusion group increased significantly, while spermatogenesis decreased significantly. In the salvianolic acid B-treated group, xanthine oxidase protein expression and malondialdehyde concentration in ipsilateral testes decreased significantly, while spermatogenesis increased significantly, compared with the testicular ischemia-reperfusion group. These results suggest that salvianolic acid B can attenuate testicular torsion/detorsion-induced ischemia/reperfusion injury by downregulating the xanthine oxidase protein expression to inhibit reactive oxygen species formation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attenuation Effect of Salvianolic Acid B on Testicular Ischemia-Reperfusion Injury in Rats

Wei

Huang

2022

Oxidative Medicine and Cellular Longevity

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“…The renin–angiotensin system (RAS) creates angiotensin II (Ang II) that causes vasoconstriction and activates inflammatory factors leading to hepatic, vascular and, renal damages. Reactive oxygen species (ROS) can promote tissue injury and vascular disease (Jafari et al, 2020, 2021; Papaharalambus & Griendling, 2007; Yazdani et al., 2019). Genistein has tyrosine kinase activating effects which can reduce oxidative damage and it protects cells against ROS by inhibiting Ang II.…”

Section: Therapeutic Effects Of Genisteinmentioning

confidence: 99%

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

Nazari-Khanamiri

Ghasemnejad‐Berenji

2021

J Food Biochem

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Genistein is the simplest secondary metabolite in soybeans and belongs to a group of compounds called isoflavones. It is a phytoestrogen and it makes up more than 60% of soy isoflavones. Studies have shown the anti‐inflammatory, anti‐apoptotic, and anti‐angiogenic effects of genistein in addition to its modulatory effects on steroidal hormone receptors. In this review, we discuss the pharmacologic and therapeutic effects of genistein on various diseases. Practical applications In this review, we have discussed the therapeutic effects of genistein as the main constituent of soybeans on health conditions. Its antioxidant, anti‐inflammatory, anti‐apoptotic and, anti‐angiogenic effects need more attention. The pharmacological properties of genistein make this natural isoflavone a potential treatment for various diseases such as postmenopausal symptoms, cancer, bone, brain, and heart diseases. Special emphasis should be given to it, resulting in using it in clinical as a safe, potent, and bioactive molecule.

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“…Increased oxidative stress is a major insult in pulmonary injury including ALI and ARDS, two clinical manifestations of acute respiratory failure with substantially high morbidity and mortality (Chow et al 2003). Oxidative stress is the result of an imbalance between oxidant production and antioxidant mechanisms that leads to oxidative damage, including lipid peroxidation and DNA oxidation (Jafari et al 2020;Yazdani et al 2019). In addition to the neutrophil infiltration and release of ROS, viral infections are associated with a decrease in antioxidant defenses (Camini et al 2017).…”

Section: Ghrelin and The Potential Beneficial Effects On Covid-19mentioning

confidence: 99%

Potential Antioxidative, Anti‐inflammatory and Immunomodulatory Effects of Ghrelin, an Endogenous Peptide from the Stomach in SARS-CoV2 Infection

Jafari

Sadeghpour

Ghasemnejad‐Berenji

et al. 2021

Int J Pept Res Ther

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The current COVID-19 pandemic is one of the most devastating events in recent history. The respiratory effects of this disease include acute respiratory distress syndrome, systemic inflammation, cytokine storm, and pulmonary fibrosis. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is a peptide hormone secreted mainly by the stomach. Interestingly, ghrelin possesses promising antioxidant, anti-and inflammatory effects, making it an attractive agent to reduce the complications of the SARS-CoV-2. In addition, ghrelin exerts a wide range of immunomodulatory and anti-inflammatory effects and can mitigate the uncontrolled cytokine production responsible for acute lung injury by upregulating PPARγ and down-regulating NF-κB expression. Ghrelin has also been reported to enhance Nrf2 expression in inflammatory conditions which led to the suppression of oxidative stress. The current opinion summarizes the evidence for the possible pharmacological benefits of ghrelin in the therapeutic management of SARS-CoV-2 infection.

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Topiramate: A novel protective agent against ischemia reperfusion-induced oxidative injury after testicular torsion/detorsion

Cited by 23 publications

References 27 publications

Attenuation Effect of Salvianolic Acid B on Testicular Ischemia-Reperfusion Injury in Rats

Attenuation Effect of Salvianolic Acid B on Testicular Ischemia-Reperfusion Injury in Rats

Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview

Potential Antioxidative, Anti‐inflammatory and Immunomodulatory Effects of Ghrelin, an Endogenous Peptide from the Stomach in SARS-CoV2 Infection

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