Topiramate for binge eating disorder

A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam

“…The other three drugs tested (topiramate, sibutramine, and fluoxetine) have been reported to reduce binge eating in humans McElroy et al 2007;De Bernardi et al 2005;Appolinario et al 2002 Leombruni et al 2008;Shapiro et al 2007;Arnold et al 2002;Carter et al 2003; National Institute for Clinical Excellence 2004), even though only fluoxetine has been accepted by the FDA to treat the symptomatology in bulimia nervosa. Therefore, the three drugs were tested to assess the predictive validity of the experimental model.…”

“…Thus, the effect of topiramate was evident only in conditions in which binge-type eating occurred. Accordingly, several clinical reports have shown that topiramate significantly reduces binge eating episodes, reduces weight gain associated with binge eating disorders, and improves the severity and compulsive features of binge eating disorders McElroy et al 2007;De Bernardi et al 2005). Further studies are needed to evaluate the mechanism of action of topiramate on binge eating.…”

“…They were chosen since clinical studies have reported that they may be effective in the treatment of bingeing-related eating disorders McElroy et al 2007;De Bernardi et al 2005;Appolinario et al 2002;Appolinario et al 2004;Milano et al 2005;Wilfley et al 2008;Leombruni et al 2008;Shapiro et al 2007;Arnold et al 2002;Carter et al 2003;National Institute for Clinical Excellence 2004). Sibutramine (Reductil®) is a centrally acting serotonin-noradrenaline reuptake inhibitor.…”

Retinal function and histopathology in rabbits treated with Topiramate

“…9 Initially, complex epilepsy was the only indication for treatment with topiramate. Recently it has been suggested that topiramate may be useful in the treatment of obesity [10][11][12][13][14][15] , eating disorders [16][17][18][19][20] , migraine [21][22][23][24][25][26][27][28][29][30][31] , bipolar disorders [32][33][34][35] , other psychiatric disorders [36][37][38][39][40][41][42] , alcohol dependence [43][44][45][46][47] and other addictive disorders 48 . Also the drug is more frequently used in the management of childhood epilepsy [49][50][51] .…”

Multivariate therapeutic approach to binge-eating disorder: combined nutritional, psychological and pharmacological treatment

“…Instituting a regimen of appropriate diet and physical activity in a purely nutritional approach to the obesity problem, which represents the patient's main concern, and to the related metabolic syndrome, has produced only modest shortterm results. Administration of weight-reducing-related drugs (topiramate, sibutramine, d-fenfluramine, orlistat) to reduce excessive food consumption, obesity and the metabolic syndrome brings about temporary small weight losses and frequent relapses, with persistence of the psychopathological aspects of the disease representing a stimulus for the maintenance of the eating disorder (Stunkard et al, 1996;Richard et al, 2000;Shapira et al, 2000;Appolinario et al, 2002aAppolinario et al, , 2002bAppolinario et al, , 2003Carter et al, 2003;Mitchell et al, 2003;McElroy et al, 2003aMcElroy et al, , 2004McElroy et al, , 2005De Bernardi et al, 2005;Fitchet, 2005;Grilo et al, 2005;Loew et al, 2006). Psychotherapy, with cognitive behavioural therapy (CBT) or interpersonal therapy (ITP), has proved effective in the short term, that is, it reduces impulsive-compulsive binge-eating frequency and severity and improves the psychopathologies specific to the disorder in the short term; however, it is less effective in the long term and in improving overweight and related metabolic alterations (Telch et al, 1990;Fairburn and Cooper, 1993;Wilfley et al, 1993Wilfley et al, , 2000Wilfley et al, , 2002Agras et al, 1994Agras et al, , 1995Agras et al, , 1997Carter and Fairburn, 1998;Fichter et al, 1998;McElroy et al, 2000;Nauta et al, 2000;Arnold et al, 2002;Marchesini et al, 2002;Zhou and Walsh, 2002;Carter et al, 2003;…”