Topiramate Reduces Aortic Cross-Clamping-Induced Lung Injury in Male Rats

Abstract

A B ST R AC T Background: Topiramate (TPM) decreases cytokine release and generation of reactive oxygen species (ROS). Cytokine and endothelin-1 (ET-1) secretion and ROS formation play an important role in ischemia-reperfusion (I/R) injury. We aimed to evaluate whether TPM prevents damage occurring in lung tissue during I/R. Materials and Methods: A total of 27 Wistar albino rats were divided into three groups of nine. To the I/R group, two hours of ischemia via infrarenal abdominal aorta cross-ligation and then two hours of reperfusion process were applied. TPM (100 mg/kg/day) orally for seven days was administered in the TPM treatment group. After the last dose of TPM treatment, respectively, two hours of ischemia and two hours of reperfusion were applied in this group. Results: Tumor necrosis factor-alpha (TNF-α) (p < 0.05), malondialdehyde (MDA) (p < 0.05), myeloperoxidase (MPO) (p < 0.05) and ET-1 (p < 0.05) levels of TPM treatment group's lung tissue were significantly lower than for the I/R group. Caspase-3 and histopathological damage were rather lower than that of the I/R group. Conclusions: During I/R, lung damage occurs due to excessive TNF-α and ET-1 release and ROS generation. TPM could well reduce development of lung damage by decreasing cytokine and ET-1 release and levels of ROS produced. K E Y WO R D S Topiramate; ischemia-reperfusion; lung injury; tumor necrosis factor-alpha; endothelin-1

Gastro protecting influence of Topiramate in ethanol produced gastric ulcers in rats

“…TPM in doses of 50 mg, 100 mg, and 200 mg/Kg body weight was administered orally. The doses of TPM were selected based on earlier studies [ [15] , [16] , [17] ].…”

Tea Grape Reduces Abdominal Aortic Occlusion-Induced Lung Injury

“…Erer et al [ 22 ] reported pulmonary alveolar debris accumulation and inflammation and edematous areas in interstitial regions following aortic occlusion. Similarly, in their study of aortic cross-clamp-induced lung injury, Kurt et al [ 21 ] observed vascular congestion, edema, and inflammation in interstitial areas. However, they reported no alveolar hyaline cast structure or alveolar wall thickening, although alveolar dilations were present.…”

“…Previous studies reported alveolar dilatation in lung tissue, vascular congestion, lymphocyte infiltration, hyaline cast structure, alveolar wall thickening, and degenerating epithelial cells as a result of aortic occlusion [ 20 , 21 ] . Erer et al [ 22 ] reported pulmonary alveolar debris accumulation and inflammation and edematous areas in interstitial regions following aortic occlusion.…”

“…Findik et al [ 23 ] demonstrated that abdominal aorta I/R resulted in apoptosis in pneumocytes in lung tissue. Kurt et al [ 21 ] observed that aortic cross-clamping resulted in apoptosis in pulmonary cells by increasing caspase-3 expression. In our study, we determined an increase in caspase-3 positivity in type I and type II pneumocytes following aortic occlusion.…”

Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture

“…Previous studies have reported severe degeneration in alveolar structures, interstitial edema, inflammatory cell infiltration, and vascular congestion as a result of I/Rep induced by occlusion of the IAA. [ 15 - 17 ] Additionally, Kurt et al[ 17 ] observed edema and hyaline cast structures in transition areas of the respiratory bronchioles, dilatation in the saccus alveolaris, edema in the subepithelial bronchial region, as well as irregularity in the lamina propria, perivascular edema, and obstruction in small capillary vessels as a result of I/Rep at examination of pulmonary tissues. Yaman et al[ 16 ] recorded swelling and vacuolization in the bronchial epithelium, increased pulmonary vascular permeability, and dilatation in the alveoli.…”