Topkin�?Eine resorbierbare Folie aus Lactid-Caprolacton

Porté, Thomas; Faschingbauer, M.; Seide, K.; Jürgens, Christian

doi:10.1007/s10039-003-0811-3

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…The development and application of degradable materials as wound dressing is still in the early period [6,22,24]. The aim in their development was to produce a dressing that could be left in place until wound healing had occurred, transparency therefore is a prerequisite.…”

Section: Wound Dressingsmentioning

confidence: 99%

“…Of the 16 described publications in the orthopedic/traumatological field, only 5 are concerned with clinical applications in carpal tunnel release, the reconstruction of orbital defects or as wound dressing. Beyond that, two further publications in a non-indexed German language journal about clinical applications such as wound dressing, adhesion prophylaxis, as well as the avoidance of synostoses and recurrent peri-articular ossifications have to be mentioned [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Films in Trauma and Orthopedic Surgery

Jürgens

Schulz²,

Porté³

et al. 2006

Eur J Trauma

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Resorbable materials have gained a considerable position in the daily routine of all surgical disciplines. Natural products like catgut and collagen have been used historically. Since the development of synthetical macromolecules more than 40 years ago, the range of indications for the use of such materials has widened significantly in our daily routine. Suture materials, mesh, tissue pads, clips, screws and anchors are in use. More recent developments in the field of orthopedic and trauma surgery include screw-plate systems, wound dressing materials and films for the prevention of adhesions and ossifications. This appears to be the beginning of an era of new materials as these implants not only fulfil a temporary biomechanical role but in theory also can release a controlled amount of biologically active substances at a set timeframe. Also they are potential carriers for transplants on a cellular level. This aspect will be of importance in the orthopedic field, where resorbable films only play a minor role so far.At the moment there are six resorbable or biodegradable films or foils on the market that are used or can be used in the field of orthopedic and trauma surgery.These are foils and films made of following materials: carboxy-methyl-cellulose and hyaloronic acid (Seprafilm®), oxydized regenerated cellulose (Interceed®), polydioxanon (PDS®) and copolymers of lactid und caprolacton (Topkin®, Oprafol®, Mesofol®).Main indications for their use are wound dressing, especially after split skin graft and thermal wounds, prophylaxis of adhesions and prevention of the formation of synostoses and heterotopic ossifications. The results of clinical trials are promising and the increasing number of publications in the last 5 years in this field is an expression of increasing demand of these materials. However, it could also be an expression of the growing interest in drug delivery techniques as well as in tissue engineering which are possible with these materials.

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Section: Wound Dressingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biodegradable Films in Trauma and Orthopedic Surgery

Jürgens

Schulz²,

Porté³

et al. 2006

Eur J Trauma

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“…For decades, these degradable polymers have been widely used as sutures or bone fixation devices and as drug delivery systems [16,17]. More recently, foils produced from poly(lactide-co-ε-caprolactone), available under the trade names of Topkin (Biomed Merck BioMaterials GmbH) or Oprafol (Lohmann & Rauscher), have been used as resorbable wound dressings [18,19]. Skin substitutes in the form of membranes based on DL-lactide (> 70%), trimethylenecarbonate and ε-caprolactone (Suprathel, PolyMedics Innovations GmbH) [20] were introduced afterwards.…”

Section: Introductionmentioning

confidence: 99%

Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering

Zuber

Borowczyk

Zimoląg

et al. 2014

Cellular and Molecular Biology Letters

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Degradable aliphatic polyesters such as polylactides, polyglycolides and their copolymers are used in several biomedical and pharmaceutical applications. We analyzed the influence of poly(L-lactide-co-glycolide) (PLGA) thin films on the adhesion, proliferation, motility and differentiation of primary human skin keratinocytes and fibroblasts in the context of their potential use as cell carriers for skin tissue engineering. We did not observe visible differences in the morphology, focal contact appearance, or actin cytoskeleton organization of skin cells cultured on PLGA films compared to those cultured under control conditions. Moreover, we did not detect biologically significant differences in proliferative activity, migration parameters, level of differentiation, or expression of vinculin when the cells were cultured on PLGA films and tissue culture polystyrene. Our results indicate that PLGA films do not affect the basic functions of primary human skin keratinocytes and fibroblasts and thus show acceptable biocompatibility in vitro, paving the way for their use as biomaterials for skin tissue engineering.

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Topkin�?Eine resorbierbare Folie aus Lactid-Caprolacton

Cited by 2 publications

References 28 publications

Biodegradable Films in Trauma and Orthopedic Surgery

Biodegradable Films in Trauma and Orthopedic Surgery

Poly(L-lactide-co-glycolide) thin films can act as autologous cell carriers for skin tissue engineering

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