Topographic abnormalities in event‐related potentials in children with monosyptomatic nocturnal enuresis

Abstract

When different levels of maturational delay are considered in MNE, it may be claimed that maturational delay in children whose enuresis lasts until older ages will be different from those whose enuresis ends at an early age. The determination of P300 amplitude in parietal records being less in enuretics when compared to the controls may show that there are regional differences in stimuli processing rate/quality.

Spontaneous brain activity changes in children with primary monosymptomatic nocturnal enuresis: A resting‐state fMRI study

“…For example, in EEG recordings of children with PMNE, there was a decrease in alpha activity in the left temporal lobe and in both frontal lobes, as well as an increase in delta activity in the right temporal region, during the resting state 23. Abnormalities in ERPs and brainstem auditory‐evoked responses were also reported in children with nocturnal enuresis 6, 24. According to the characteristics of resting‐state fMRI, we mainly focused on abnormalities of forebrain in children with PMNE; such abnormalities might be caused by a developmental delay.…”

Changes in the Brain Microstructure of Children with Primary Monosymptomatic Nocturnal Enuresis: A Diffusion Tensor Imaging Study

“…The mean map was smoothed (using a [6,6,6] FWHM Gaussian kernel) to obtain our FA-specific pediatric template for further analysis [43]. Subsequently, we normalized all of the original FA maps (from both patient and control groups) based on the deformation field produced from both the original FA maps and our FA-specific pediatric template.…”

“…Subsequently, we normalized all of the original FA maps (from both patient and control groups) based on the deformation field produced from both the original FA maps and our FA-specific pediatric template. Then, the normalized FA maps were smoothed (using a [6,6,6] filter) for the statistical analysis. Finally, a fractional design specification was set up to compare the PMNE group against the controls using a two-sample t-test.…”

“…In the past, electroencephalograph (EEG) [5], event-related brain potential (ERP) [6], and the startle blink [7] have all been used to study enuresis. It has been observed that the maturational delay of the central nervous system is an important factor in the pathogenesis of nocturnal enuresis [5], [6], [7], because it can induce functional and structural abnormalities in some brain areas. Using functional magnetic resonance imaging (fMRI), a number of studies have reported alterations in several brain functions in patients with urgency and urge incontinence [8], [9].…”

Task positive and default mode networks during a working memory in children with primary monosymptomatic nocturnal enuresis and healthy controls

“…event-related brain potentials indicated that maturational delays in central nervous system development are indicators of PMNE pathogenesis (5)(6)(7)(8). Primary nocturnal enuresis children show a higher prevalence of all sleep disturbances (9).…”